Hiiiiiii welcome +_+
you could travel the channels to see if you can benefits or help in something
and read rules
MEE6BOT
GG @ibtisam.midlet, you just advanced to level 5!
Maevoleth
Hey guys
New to the idea of altering my body positively. I've been addicted to some substances for about a decade now, and i'm on anti-psyche medication. Hoping biohacking and something like neuralink in future can help me regulate my chemicals but for now i'm looking here
ibtisam.midlet
NAD+ IV has shown to decrease heroin intake by 80%
psychedelics has anti addiction effect proposed generally
@Maevoleth
Hey guys
ibtisam.midlet
what's your addiction exactly
Maevoleth
THC, Nicotine and Caffeine
Used to be on ritalin but no longer
@Maevoleth
Used to be on ritalin but no longer
ibtisam.midlet
That's not an addiction that life improving
Anyway coffee should not be counted
But nicotine switch to vap
I think it mostly you are addicted to hand to mouth move more then effect of nicotine if any
This really hard to fix, due being dalta fos be has did positive reinforcements where he eliminated you ability to feel that bad smell of sig but made the spicy part of it more enjoyable by rewards sensitation , the same for vaping, when I get bored it almost impossible for me to stop thinking about nicotinic I'll just start generation unfair selective agreement advocate nicotine use.
The problems with full of this is dalta fos b has half life ~4months
That mean you need to stop for 4 months (no source its my xp) for craving potency to decrease "really" to half
Which we can't even stop for few weeks do to logic changes.
To this point there is not noticeably effective dfos b inhibitor.
For me D3 antagonists was useless in this regard
You might just try your luck with NAD+, just learn to inject first, small step by step and you done it.
@Sexy Seojin
Blocked message.
ibtisam.midlet
Look at emojis I stole Instagram one
ibtisam.midlet
You will get a lot of boys running over you with this
@Sexy Seojin
Blocked message.
ibtisam.midlet
this happen to voxelite, and constantly happen to me
@everyone
If you have a friend who capable to contribute in anyway, or have a problem trying to solve
inviting them to the server appreciated
Don't invite people who force thier opinion, or who are better at saying why things wouldn't work than how to make things work
Rapamycin
Aniracetam
Piracetam
Bromantane
Bacopa 24% bacosides
100 mg modafinil
Curcumin
Cacao
Ginkgo biloba
Quercetin with bromelain
ALCAR
Na r ala
Reduced glutathione
NAC
Agmatine
Shiitake mushroom
Enteric coated peppermint
Digestive enzymes for all the aforementioned
L-glutamine
B12 sublingual methylcobalmin
B6 p5p sublingual
Thiamine hcl
Methylfolate
Potassium citrate
Boron
Selenium
Molybdenum
One meal a day
The stack is for inducing extremely high pattern recognition, synesthesia, enjoyment of life which will assess my addictive tendencies, socialization skills. The stack is clearly higy effective as i just typed all this after being up for 42 hrs straight and I worked 9 hrs at the beginning of starting this wakefulness
I am impaired by high functioning autism, severe adhd and I have brain hypertension which inhibits traditional stimulants from being useful, depression, anxiety, addiction, immunocompromization (I've had molluscum contagiosum for about 4 years), chronic fatigue
I am, quite obviously, attempting to assess every issue I have in my life
My work performance has also obviously improved and I'm getting a raise soon
5thLeaf
I also did a cerebrolysin cycle 4 months ago that seemed to fix my severe visual sensory issues
I also quit a 1-4 grams per day phenibut habit 5 weeks ago w minimal wd using majority of aforementioned stack
ibtisam.midlet
[Detailed Info about each needed]
5thLeaf
Yea I'll do that and doses after I fucking sleep lmfao
ibtisam.midlet
All of them at once? Microcoding, co-factor problem, crazy half life, there just 3 considered something others can't suck dick of coffee
5thLeaf
Normally I wouldn't even go this far but I was in the mood
Wat
How do you suck coffee penis
Tell me the ways of jedi
Most of em at once yea
MEE6BOT
GG @5thLeaf, you just advanced to level 1!
5thLeaf
Bet
I'm pro
Fuck me I'm not even tired
I haven't even taken modafinil for 38 hrs
And it was 100 mg
Oh yea, fhe list is order of importance
That should help some
I listed my issues, one should be able to deduce what I'm using everything for
Er
Many things at least
Obvi most are multi faceted
I'll also add that my main strengths are long term iq and pattern recognition
Short term memory has been greatly improved by using mild 5ht2a agonists like aniracetam and agmatine
ibtisam.midlet
Thats Ampa and nmda-
To archive noticeable effect on ht2a upper dose by 200
The selective targeted not dirty drug
5thLeaf
Cacao makes aniracetam 5ht2a effects more prominent
Aniracetam is placebo without cacao
It upregulates some serotonin, I'll send study after I sleep
@5thLeaf
Rapamycin Aniracetam Piracetam Bromantane Bacopa 24% bacosides 100 mg modafinil Curcumin Cacao Ginkgo biloba Quercetin with bromelain ALCAR Na r ala Reduced glutathione NAC Agmatine Shiitake mushroom Enteric coated peppermint Digestive enzymes for all the aforementioned L-glutamine B12 sublingual methylcobalmin B6 p5p sublingual Thiamine hcl Methylfolate Potassium citrate Boron Selenium Molybdenum One meal a day
ibtisam.midlet
Moda agmatine and mushroom, that the only will work
5thLeaf
That's simply wrong
Aniracetam is potent for me
ibtisam.midlet
I took 260+ sub's
5thLeaf
With all the interactions going on it'd be foolish to assume some of the norms apply
ibtisam.midlet
I have detailed data about each
@ibtisam.midlet
I took 260+ sub's
5thLeaf
Subs?
ibtisam.midlet
Substance
5thLeaf
That's too many
Even imo
I do miss etiz for brain hypertension ngl
Surprisingly effective
Why is rapamycin so fucking stim
Half life ig
ibtisam.midlet
Did any of this made you clean you room
5thLeaf
Yea but then I got it dirty again lmao
And haven't bothered since
I clean the store at work amazing
@5thLeaf
I do miss etiz for brain hypertension ngl
ibtisam.midlet
Hypochondria
5thLeaf
But i still don't see a point in cleaning my room
@ibtisam.midlet
Hypochondria
5thLeaf
Making assumptions w inadequacy info
Prove to me benzos aren't anti hypertensive then get back to me
ibtisam.midlet
You don't have hypertension imo
5thLeaf
I'm open to debate but only if it's hempfil
Lmao
Useless server ig
L8r
MEE6BOT
GG @5thLeaf, you just advanced to level 2!
5thLeaf
Your assuming you know my life when you've talked to me for 60 min of my life total
You realize the arrogance in doing that right?
Sirsad levels
1
Rip you
Rip you
I'm sorry i can fix my problems and you cant
I'm arrogant im
Ik
But I demonstrate actions to prove it
I'm welcome to talk but not if you don't listen to what I say
Lmk if you wanna listen, for now I'm just gonna keep working on myself
I like you, but I don't like when people don't try and view things objectively or try and understand a situation
And instead just assume, hurt aforementioned person, then go on with life w no care
I actually did have hypochondria at a point
So what, I havent in 3 years
Try and use that to support your claim idrk
Do you know why all hypertensives cause me severe headaches and make me tired? Unless I take anti hypertensives to assess the issue?
Give me an answer and I'll thoroughly consider it
I've been investigating this myself for 6 months and not on my own, bc they would be useless bc self bias
No one has a better idea
So shoot your load
You don't even know the health issues I've been through lmao
Why does lad cause me a severe headache that makes me unable to think regardless of how many 5ht2c antagonists I take
I can go on
But I'm bored
And this is futile it appears
All I can do is what I've been doing, but if you genuinely have ideas please let me know
Buy Risnia 1 mg online from AllDayChemist - your most reliable online pharmacy. Avail best price in USA, by your doorsteps. Order Now!
5thLeaf
Ugh I gotta buy a po box again reee
Oh well I need more moda anyways
ibtisam.midlet
Start 0.25 or you will get tortured by it
5thLeaf
I quit memantine a month ago btw fwiw
It started causing brain fog
Wouldn't that downregulate d2 if anything?
Chronic use I mean
ibtisam.midlet
It will cause short term upregulation
5thLeaf
Define short
Bc it's been at least 4 weeks
ibtisam.midlet
Aka withdrawal symptoms
5thLeaf
And I don't take uridine
I don't get mem wd
I just nic becoming stronger
I was surprised wds from gabaergics didn't get worse when I quit it
I'll also mention phenibut doesn't help with the presumed hypertension headaches
And if hypochondriac it should?
And alcohol also worsens them
Only benzos help
Of gaba drugs
ibtisam.midlet
You talk much switching from topic to topic, causing people see you annoying= no relationships
@5thLeaf
Of gaba drugs
ibtisam.midlet
Directly Block d2 stimulant anxiety
5thLeaf
I didn't get stim anxiety all my life until a complicated health incident
In fact I had panic attacks going to school if I didn't take my adderall
@ibtisam.midlet
You talk much switching from topic to topic, causing people see you annoying= no relationships
5thLeaf
Untreated adhd + hypo(mania)?
That makes as much sense imo
However your right ppl have been less prone to talk to me the past 12 hrs
Idk I just think there's a lot of other options to consider
Why so focused on hypochondriac in particular is my main question
ibtisam.midlet
Because I have that
5thLeaf
Which means it's a very biased suggestion
Hence why I kinda raged
I hate biases
I genuinely have hypertension if I don't take herbs for it
That's easily determinable
140/115 range
ibtisam.midlet
Tested?
5thLeaf
Body hypertension is easy to asses
Yes
Doctors literally were concerned abt my blood pressure but always attributed it something else, like thay I was in the heat for an hr before coming in
ibtisam.midlet
140/115 is not considered hypertension
5thLeaf
But it's always abt that high if i dont take strong anti hypertensive herbs
Well it's elevated regardless
ibtisam.midlet
And I took ris and it caused severe hypotention
5thLeaf
If it was hypochondriac than shouldnt every substance I take make me feel a headache?
Ok explain to me risps pharma aside from D2
ibtisam.midlet
Which mean D2 control blood pleasure , increase blood pleasure when agonised
5thLeaf
Hmmm
I want a study for thag claim
That's more extrapolated than my belief
@5thLeaf
Ok explain to me risps pharma aside from D2
ibtisam.midlet
Just don't take more then 0.33mg or you will lost all your biohacking interest, 2mg and you are a Farmer
5thLeaf
Helps irritability associated with autistic disorder.
ibtisam.midlet
It lower your standards like nothing
5thLeaf
Now I will agree thay currently I do suffer from that
Should have led with that
And also I understand I need to take suggestions from friends more bc they are often righr
However I am arrogant but working on it
ibtisam.midlet
Sighlightly Lower standards the you now are good, at least you will accept to fuck the shemale you talked about even if it was not 100% perfect
D2 is destroying all your life expect and you still advocating it
5thLeaf
Yea sirs told me the same but why do they cause motivation to do shit I need to do then
Like a college application
Everything I've read says d2 bad but everything I experience says d2 good
I've been quite confused abt that
Admittedly
ibtisam.midlet
its just increase motivation for science
5thLeaf
AND I HAVE NO MOTIVATION FOR ANYTHINF NORMALLY
MEE6BOT
GG @5thLeaf, you just advanced to level 4!
5thLeaf
I literally sit around and watch TV all day normally
And shitpost
ibtisam.midlet
You are driving you hit someone killed it, because your was thinking about biology when you drive
5thLeaf
It helps me when I'm at that point but your likely right that I can get better by dropping the d2 increasers now bc other issues have been assesed
It was likely just a helpful cope when I was at my worst
If this is accurate
Which that I can agree with accepting as a high possibility
You gotta lead with this shit tho lmao
Don't save the good shit for the end
I literally was abt to leave a while ago
And now I'm glad I've stayed bc DISCOVERY REQUIRES EXPERIMENTATION
And actually I've always liked you
If someone else had approached like this I would have left
1
Hence excess d2 increasing autism irritability
But I already had that autism connection meme w you
I'm very glad this went well, that's a new one
Tbf when I don't take anything for d2 I just remain neutral in these things
And ignore em
ibtisam.midlet
You can go to any doctor say you was on ris and anafranil and he will prescript it for you
5thLeaf
But I've had same doc for numerous years
What's anafranil?
Also I'm concerned abt risperidone inverse serotonergic action but I'm noob on inverse agonism
I have to cuck 5ht2c
And need 5ht2a uncucked
ibtisam.midlet
Ris should not be take by other people in any situation
5thLeaf
Ik
Hence concern
ibtisam.midlet
You need to put your D2 on 6/10
You are 9/10
other people are 5/10
5thLeaf
I get that
But answer aforementioned q
The inverse serotonergic agonism
Wat I expect from that
Subjectively
ibtisam.midlet
it block bad serotonin receptors
5thLeaf
5ht2a good
5ht2c terrible
@5thLeaf
Subjectively
ibtisam.midlet
See receptors function db serotonin part
5thLeaf
And most inverse agonism for 2a
Db?
ibtisam.midlet
serotonin receptor are ball in park
5thLeaf
Elaborate
Yea they up and down-regulate like daily it seems
veganpermanently
Risperidone is poison
@5thLeaf
I have to cuck 5ht2c
chloitopia
agomelatine works. 1 mg subL before bed for 15 mins
1
@5thLeaf
And need 5ht2a uncucked
chloitopia
memantine works. 1 mg in the morning can do oral. using more cancels the cognitive enhancement, tho it becomes nice for some introspective work about 15 mg. but I guess you know that. Anyway the 1 mg dose is nice combo with modafinil
1
@5thLeaf
Hence excess d2 increasing autism irritability
chloitopia
memantine nooks my irritability. I guess the higher doses permanently teached me how to stay calm despite unwanted scenarios happening
1
I still get irritable it's only easier to control my reaction to the emotion
Message could not be loaded.
chloitopia
modafinil takes care of this. some weak filtered coffee. ginkgo
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Mg is good but the form you take is v bad
GABA transaminase inhibitor
compare effects to valproate
@chloitopia
MAO B expression was upregulated, it did not block catabolism, it increased it
ibtisam.midlet
It should be the opposite
MEE6BOT
GG @ibtisam.midlet, you just advanced to level 10!
Parkinson’s disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself is strongly linked to oxidative stress as its degradation generates reactive oxygen species (ROS) and DA oxidation can lead to endogenou...
What you think
@ibtisam.midlet
It should be the opposite
chloitopia
it might be neutral effect tho, the vesicles protect against MAO B oxidation
if VMAT2 and MAO B are increased simultaneously that's a desireable state
@chloitopia
I'd rather not
ibtisam.midlet
If you see something have more benefits then harm , take it
chloitopia
because it prevents autoxidation which is the worst type of dopamine metabolism
ibtisam.midlet
Give me cazino were 60% win 40% loss, I'll sell my underwear gumbel it
@ibtisam.midlet
If you see something have more benefits then harm , take it
chloitopia
the problem is short term vs long term. I was taking lemonbalm daily before. felt good but looking back it took it's toll
CBD as well. all GABAergics do this. hence why I'm now recovering with GABA antagonists
I don't go by feeling anymore
I find the most optimal intervention and use that to my benefit.
it generates better cognitive and emotional states than chasing feelings in the end anyways
MEE6BOT
GG @chloitopia, you just advanced to level 2!
chloitopia
most of what I do now has no trade off
the doses are lower than anyone else uses, for example the agomelatine. No one has done this before me yet the study is up there and the results are clear
1
@chloitopia
the problem is short term vs long term. I was taking lemonbalm daily before. felt good but looking back it took it's toll
ibtisam.midlet
Companies try to make clean substance where side effect dose is very high then good effect, you can just microdose what you want , and the longterm effect will stay good
@chloitopia
modafinil takes care of this. some weak filtered coffee. ginkgo
5thLeaf
Both are in my stack but I'm poor rn and only risk moda on work days until I order more
Had to cut my dose in half to 100 mg to ensure I'd have enough for a bit
@5thLeaf
Had to cut my dose in half to 100 mg to ensure I'd have enough for a bit
chloitopia
I take 30 mg
it works without tolerance for about a week then I stop
5thLeaf
I just don't take daily
I surprisingly have no tolly issues w moda
I've been using 4-6x a week for a few months
chloitopia
well u don't take it daily
it takes a long time to develop tolerance even on such a small dose I take
5thLeaf
Yea but I develop tolerance to substances fast so I'm still surprised
chloitopia
moda has a unique MoA
5thLeaf
Inflammation is my only guess bc nmda antagonism doesn't help
chloitopia
it's not the DRI effect
but it is dopaminergic for sure
5thLeaf
Yea orexin?
chloitopia
it's a vesicular release agent
orexin release agent as well
5thLeaf
What I love abt it is its not really hypertensive
chloitopia
you have to have a lot of vesicular release to develop tolerance
it's natural in a way
5thLeaf
Please stop talking about my vehicles in casual, it makes me uncomfortable
1
/ s
chloitopia
electrically evoked monoamine release
@5thLeaf
Please stop talking about my vehicles in casual, it makes me uncomfortable
chloitopia
why is everyone like this
5thLeaf
I love electricity, sometimes I put the toaster in the bath
chloitopia
makes me shut down
5thLeaf
It's a funny word I'm sorry
You may continue I'm listening and will confine shitpostinf to external servers
chloitopia
rage quit a vegan server yesterday
if I can't geek out I won't even talk to you
idc
5thLeaf
Oh I want you to geek out
Wait was it vegan permanently server
@5thLeaf
Wait was it vegan permanently server
chloitopia
i am VP
no it was some goofy vegan dating server
they don't let you use the R word on yourself
have pronoun tags
etc
they get offended by your beliefs
imagine that
I can't even identify with vegan groups nowadays
the only thing we have in common is that we avoid animal abuse
5thLeaf
Lmao at work I say "HEY WE DONT USE THAT WORD HERE" when someone says retard
It's a kitchen
chloitopia
but other than that we're a diff species
@5thLeaf
It's a kitchen
chloitopia
kek
that's the funny part
everyone and their mother snorting K in the toilet but you can't use the R word
everyone and their mother snorting K in the toilet but you can't use the R word
5thLeaf
LMAO HOWD YOU KNKW I DID THIS
Nah we can use the r word
I use it
chloitopia
bcs it's a kitchen
MEE6BOT
GG @chloitopia, you just advanced to level 3!
chloitopia
all kitchens are the same
drug holes
5thLeaf
No one does dissos at my work
Even the smart mfers tried telling me nitrous can kill you easily
Everyone drinks on the job tho
And smokes
MEE6BOT
GG @5thLeaf, you just advanced to level 5!
chloitopia
well tbf it was meant as a parabole
5thLeaf
Basic bitch shit
K is for horses.
chloitopia
no amph?
5thLeaf
I did struggle to close when nearly holing on too much bathroom k once lmfao
I can't flip my amp script at work surprisingly
chloitopia
moda is the perfect kitchen drug
as long as the ventilation is on point
because otherwise you'll heat out quick
5thLeaf
I need heat for cognition
I volunteer to do hoods in 105F
And that takes an hr
chloitopia
moda increases thermogenesis
5thLeaf
Yea if I don't sweat I don't think well
chloitopia
if u have brown fat it can feel hellish
5thLeaf
I'm white
I'm gonna guess that's not what you meant
chloitopia
no
chloitopia
no
it's fat with metabolic properties
kinda based
white fat browns when exposed to cold
5thLeaf
I see
chloitopia
increases cold tolerance
5thLeaf
Hmmmm
chloitopia
but also makes you heat out if 5ht2a is activated at high ambient temp
5thLeaf
I used to be very tolerant to cold and hated heat
Then it flipped
chloitopia
u lost brown fat
5thLeaf
When I was tolerant to cold my diet was trash
I've also ruled out thyroid ofc
chloitopia
drink some olive oil and spend time in a walk in freezer
5thLeaf
Seeing as I have chronic fatigue I had to make sure I wasn't hypothyroid
chloitopia
fasting mimicking diet, rinse and repeat
5thLeaf
FUCK THE WALK INS
So cold
I am doing lower fat rn bc drug test later this month but after that I'll try
I normally eat lots of peanut butter
chloitopia
I maintain subQ fat
these gymbros insecure idiots
if I can see my abs it's time to crush the plate
5thLeaf
Oop
Yea my issue likely correlates to abs becoming more pronounced
I'm amazed I couldn't sleep more
Rapamycin is wack
chloitopia
it is
i get these stim effects as well
well no one did until I told everyone about it
5thLeaf
I'm curious how it will impact my treatment resistant molluscum contagiosum
chloitopia
so I tend to think it's a meme
5thLeaf
I had never heard of it being a stim
And my fatigue is also due to health issues
chloitopia
I guess it is then
was uncomfortable when I snorted it
5 mg oral is fine
5thLeaf
So it makes sense I'd hyperrespond to this effect, and in reality it's probably also increasing my ability to get stimmed from rest of stack bc health is better
I can't afford to oral that
I'd run out fast
Do you have a source for it atm?
chloitopia
a bit too much autophagy paired with fasting mimicking diet tho
5thLeaf
I need that for a bit I'd think
chloitopia
has muscle pains, a headache
5thLeaf
I have a bit of cancer in my genes
chloitopia
but I guess it did clear some cancerous cells
yesterday I had a customer on chemo
that's horrifying
worth every intervention
5thLeaf
But yea I stayed up for 44 hrs unintentionally bc rapa, and could only sleep 4.5
I didn't even moda yesterday
chloitopia
did u snort it
5thLeaf
Yea
Also yea my mom has a rare leukemia and severely low platelet count
chloitopia
I don't think it's a good idea now
5thLeaf
Her platelets were in single digits once
chloitopia
get some pomiferin
5thLeaf
Amd then she got thyroid cancer
chloitopia
my ex had ovary cancer
5thLeaf
Oof
That sounds painful
Coffee causes me headaches if I have a cup, but for some reason I need 1/4 to 1/2 cup a day for some reason
chloitopia
bitch gets what she deserves
1
5thLeaf
Ok it's stack time
puts on timer
chloitopia
I decided to stop eating after 5 pm
5thLeaf
Any idea of ultra low dose naltrexone is a terrible idea with rapamycin
@chloitopia
I decided to stop eating after 5 pm
5thLeaf
That's smart
machineyadav
No idea
MEE6BOT
GG @machineyadav, you just advanced to level 2!
5thLeaf
Most ppl eat too late
@5thLeaf
Any idea of ultra low dose naltrexone is a terrible idea with rapamycin
chloitopia
should be good
5thLeaf
Ok that's gonna be my final attempt to cure my viral infection
I give up if that combo w everything else I take doesn't work
It's been lime 6 years
I can't have sex bc of it
chloitopia
lyme disease?
I tested myself recently
negative
5thLeaf
I may have thay too but haven't tested
But no, benign but awful molluscum contagiosum
chloitopia
oh
5thLeaf
Only supposed to last behind 2 years in severely immunocomp ppl
I've had over 6
chloitopia
I don't have sex to prevent shit like that
past 4 years
5thLeaf
IM A VIRGIN
chloitopia
had one relapse
5thLeaf
I got an std and I'm a virgin.
chloitopia
regretted it instantly
MEE6BOT
GG @chloitopia, you just advanced to level 4!
chloitopia
got up and left
@5thLeaf
IM A VIRGIN
Mabus Tiefsee
50 bucks and no standards can change that
chloitopia
how the fuck did you manage to remain virgin
5thLeaf
Lmao no I'm actually hot
I've had to turn down offers for sex
chloitopia
ur a strong man
my guy
i thought I was monking out
5thLeaf
I don't lift
Kek
But yea I was in my dream girls bed
chloitopia
u do women
5thLeaf
She wanted it
I was too autistic to explain my situation
@5thLeaf
I got an std and I'm a virgin.
Mabus Tiefsee
sounds like responsible patents....
chloitopia
if everyone was like u all women would be saints
5thLeaf
So it was just a cuddle sesh
Then she tried again in the morning lmao
Put my hands on her tits
chloitopia
slut
5thLeaf
Then when I obviously wasn't gonna fuck she said she had to go see her sister
chloitopia
slap
spit
spank
5thLeaf
We met at a bar so probably tbfh
That was my first time ever going to a bar and j wasn't even 21 lmao
And I went home with a 10
@5thLeaf
Then when I obviously wasn't gonna fuck she said she had to go see her sister
chloitopia
next Tinder match
codename
Mabus Tiefsee
the std, an incurable one?
5thLeaf
Mines treatment resistant
Severely
Mabus Tiefsee
that sucks
5thLeaf
Tell me abt it
I wasn't an addict until I got it
Mabus Tiefsee
trying sonething crazy to cure it with biohacking or did you acept your fate?
5thLeaf
Trying something very crazy
The kitchen sink
chloitopia
try histidine
overload BCAAs
limit tryptophan
and bomb rapamycin oral
all at the same time
5thLeaf
I notice serotonin upregulation worsens it
Aka cacao
chloitopia
indeed IDO is antiviral
nooking IDO will provide an edge to viruses
5thLeaf
IDO?
Mabus Tiefsee
if you need any crazy new ideas, tell me the std - i always come up with crazy ideas... besides i am limited extremly with biohacking because of my country. Therefore theory and stoneage biohacking is all i got...
chloitopia
indoleamine dioxygenase
@Mabus Tiefsee
if you need any crazy new ideas, tell me the std - i always come up with crazy ideas... besides i am limited extremly with biohacking because of my country. Therefore theory and stoneage biohacking is all i got...
5thLeaf
It's molluscum contagiosum, you can scroll up for additional context
Current plan is focused on low dose naltrexone + rapamycin
And rest of my stack
Mabus Tiefsee
wait, it is a pocks strain? Immunity against one pocks version often helps against others. Did you already trow some close but more harmless pocks strains into the kitchen sink?
5thLeaf
Uhhh no
How would I even
Buy em from Rothschild?
Lmao
Mabus Tiefsee
monkey pox home delivery service, just ask some gay dudes if they got connections. The worst orgys should have them
chloitopia
disgusting
Mabus Tiefsee
and asking your doctor for an old pox vaccine, the they could still work (first pox vaccine was just a weak pox strain. That's the reason many got a scar at the incection site)
@chloitopia
disgusting
Mabus Tiefsee
yes
oh and high dose vitamin C, some cink and high dose vitamin D
Just for boosting your immune system.
5thLeaf
Yea i take all those
chloitopia
50 k IU Lesss goo
5thLeaf
Oh I forgot to include reacta c in my stack
Mabus Tiefsee
....like i sayd, crazy ideas are my speciallity...
5thLeaf
Rapamycin
Aniracetam
Piracetam
Bromantane
Bacopa 24% bacosides
100 mg modafinil
Curcumin
Cacao
Ginkgo biloba
ALCAR
Na r ala
Reduced glutathione
NAC
Shiitake mushroom
Enteric coated peppermint
Digestive enzymes for all the aforementioned
B12 sublingual methylcobalmin
B6 p5p sublingual
Thiamine hcl
Methylfolate
Potassium citrate
Boron
Selenium
Molybdenum
One meal a day@Mabus Tiefsee
chloitopia
knock on wood my zoster infection hasn't returned for 4 yrs
I guess all I need to do is avoid bitches
Mabus Tiefsee
all it needed for me (even during my most horny time as teenager) for loosing all interests in her. Blisters on the lips....
MEE6BOT
GG @Mabus Tiefsee, you just advanced to level 4!
@Mabus Tiefsee
all it needed for me (even during my most horny time as teenager) for loosing all interests in her. Blisters on the lips....
chloitopia
simplex is nothing compared to zoster
zoster gives you debilitating back pain
you can't get up even
ever move is like a thousand daggers through your spine
Mabus Tiefsee
sounds awfull
chloitopia
it is evil
attacks your nerves in the spinal cord
some people have these pains permanently
and no painkiller helps it
Mabus Tiefsee
don't forget to freeze a sample of infectious material as backup plan in case you need it one day
chloitopia
nooked it with acyclovir
should probably stock up on femcyclovir in case it comes back
Mabus Tiefsee
and avoid bitches, that hour of fun is not worth any std, even the not as serious ones....
chloitopia
ofc
I'm monk
1
no PMS
Mabus Tiefsee
yeah a guy has to go his own way, i agree
chloitopia
also no porn
that's literal brain damage
Mabus Tiefsee
hold on....
chloitopia
to be fair it's not really strong science but it does feel like it
Mabus Tiefsee
no women and no porn? How do you manage your hormones? I can have either or - but both, how?
@Mabus Tiefsee
no women and no porn? How do you manage your hormones? I can have either or - but both, how?
chloitopia
great inhibitory control
I've upregulated my GABA neurons to the point I can enjoy not induldging compulsions in a way
Mabus Tiefsee
was it before the infection as well? Pain reducing your dribes makes sense. Otherwise you migt want to check your hormon levels. Just to be sure.
@Mabus Tiefsee
was it before the infection as well? Pain reducing your dribes makes sense. Otherwise you migt want to check your hormon levels. Just to be sure.
chloitopia
no this happened only after I took my stack
before that I couldn't even manage to not smoke weed
Mabus Tiefsee
ah direct brain alteration, yeah that explains it
chloitopia
avoid GABAergics
introduce GABA antagonists and release inhibitors
result is stronger inhibitory neurotransmission over time
Mabus Tiefsee
no, can't do that. That would make reproduction difficult
chloitopia
reproduction of what
Mabus Tiefsee
human ofspring
chloitopia
I don't intend to have children but I'm curious what you're on about
I'm busy planning world domination I don't have time for little gremlins
@chloitopia
I'm busy planning world domination I don't have time for little gremlins
Pax1l
Mabus Tiefsee
sperm donations for those who want to raise my ofspring for me
minimal risk & investment, maximal offspring numbers. I am switching from a K strategy to an R strategy in reproduction. If just one out of ten children will develop good, it is a win - simple math.
chloitopia
if I can't indoctrinate them there is no point
@chloitopia
I'm busy planning world domination I don't have time for little gremlins
Mabus Tiefsee
that's why i said freeze infectious tissue! Use it as starting point and make an airborn version. In case ypu need a hostage, take the whole world!
chloitopia
gremlins are ideal cult followers but you need to actually do it
@chloitopia
if I can't indoctrinate them there is no point
Mabus Tiefsee
the question is, do you think nature or nurture. I believe it is 60-90% nature and the remaining nurture is neglectable.
@Mabus Tiefsee
the question is, do you think nature or nurture. I believe it is 60-90% nature and the remaining nurture is neglectable.
chloitopia
nurture all the way
Mabus Tiefsee
in that case, become a teacher
@Mabus Tiefsee
in that case, become a teacher
chloitopia
no that's just adding a drop to a sea it does nothing
Mabus Tiefsee
kindergardenteacher
chloitopia
I need them isolated until they're fully grown up and trained
Mabus Tiefsee
they see the children more often than the parents if you exclude sleeping time
tell that to pokemon. Make a game, you can hide anything in there and it works better as everything the teachers would teach anyway
@Mabus Tiefsee
tell that to pokemon. Make a game, you can hide anything in there and it works better as everything the teachers would teach anyway
chloitopia
ur right should prolly take a more legally sound approach
Mabus Tiefsee
and hide the thing afzer 3h of playtime. That way the parents won't find out.
The problem DnD made, they showed the satanic stuff during character creation!
5thLeaf
I'm shaking
I've been on rapamycin 3 days and my viral infection I've had for 6+ years is going away
One of the largest bumps I had is just gone
GONE
@5thLeaf
One of the largest bumps I had is just gone
chloitopia
nice
it's potent
make sure to do other biohacks to prevent bacterial infections
AbstractBackground. Clinical data indicate that therapy with small-molecule immunosuppressive drugs is frequently accompanied by an incidence rate of neuropsych
found it
5thLeaf
Hmmmm it's anxiolytic for me
Does bring down my childhood leaning toward hypolanic bipolar
But I was in depression for past 7 years and constantly abused drugs so it's worth the trade
I also have never been diagnosed with bipolar
@chloitopia
S. montana oil aromatherapy
5thLeaf
Alternatives?
I'm sure I have something helpful at home
ibtisam.midlet
@5thLeaf
5thLeaf
Hi fren
I just found 7 amp
Free money
That's literally $105 in my pocket
It's a good week
5thLeaf
I also am now a synesthetic
MEE6BOT
GG @5thLeaf, you just advanced to level 6!
5thLeaf
At least w current stack
Another long term goal achieved
5thLeaf
Bro getting rid of this fucking nft is a huge pain
I got it for free
5thLeaf
Ok I need crypto, who wants to buy piracetam or aniracetam
@5thLeaf
Alternatives?
chloitopia
search antiobiotic herb. I found this one to take care of Streptococcus aureus
search antiobiotic herb. I found this one to take care of Streptococcus aureus
5thLeaf
Oh I already cured my recurrent mrsa
I actually was getting close to needing an amputation lmfao
Entire leg was severely red and antibiotics made it spread more
chloitopia
the thing is
5thLeaf
Researched and found articles on Manuka honey, asked the doctor abt it and he advised against it, did it anyways and next day doctor goes "idk what your doing but keep doing it"
Fuck doctors lmao
chloitopia
S. auerus is a natural part of the nasal microbiome
5thLeaf
I'm aware
chloitopia
secretes toxins which directly access the brain
5thLeaf
I meant I cured getting recurrent infections
Hm didn't know that part
chloitopia
which is why I wanted to nook it
and found the oil to do it
5thLeaf
But you'd have to do that daily
Forever
And ever
And ever
ever echoing in the distance
chloitopia
yeah well I like S montana smell
I don't mind my house smelling like that all the time
@5thLeaf
Researched and found articles on Manuka honey, asked the doctor abt it and he advised against it, did it anyways and next day doctor goes "idk what your doing but keep doing it"
chloitopia
classic doctor behavior
if there's something they were not thought in school
the automatic response is to say no
true NPC behavior
tho' there may be legal liabilities about this
so that's one reason for this
@chloitopia
the automatic response is to say no
5thLeaf
The problem is they're also taught to do that
They're actually essentially taught not to think in a way
chloitopia
I ate an Arum sp. leaf once
5thLeaf
Independently
I am a leaf
chloitopia
came choking to my doc
they told me 'we don't know what it is go home'
5thLeaf
Idek what that is fam this isn't going well
Sounds right
I'm surprised they didn't just give you charcoal
They should always do that if they don't know
At worst it'll have a neutral effect
At best it'll work
chloitopia
that's the most poisonous plant one could consume in Europe
I could have died if I only ate a bit more
5thLeaf
They don't have Datura in europe?
chloitopia
this is more poisonous than datura by far
5thLeaf
But more fun inbet
S
chloitopia
nah
it just makes you choke
and you die
5thLeaf
Some people like that tbh
Weird people
chloitopia
my ex
stupid bitch
5thLeaf
What's the moa
Did u kill her
/s
chloitopia
idk I'll look it up
5thLeaf
Too much kink choking
Lmfao
chloitopia
no she begged me
I slapped her
'why did you slap me'
'because you're a dumb bitch'
proceeds with the pounding
5thLeaf
Thud
Thud
Thud
Door opens
chloitopia
wtf
the MoA is literally calcium oxalate
brazing your throat
oh
so this promotes absorption of cyanoglycosides
5thLeaf
FUN
chloitopia
funny thing
my diet is literally slowly poisoning me
5thLeaf
That's common
Too many oxalates?
@5thLeaf
Too many oxalates?
chloitopia
I'll eat over 2 g by the end of the day today
that spinach champignon stew
5thLeaf
NOT SPINACH NOO
The fucking worst
You can literally feel the oxalates
chloitopia
yeah well IDC
because I made the best recipe in the world
5thLeaf
eats more cacao
chloitopia
you can't go beyond this no way
5thLeaf
I'm a cook
So your probably right
chloitopia
me too
but I choose not to work for a cuck
5thLeaf
That's why you bully your coworkers into complacency ezpz
I owe lawyers and fam
Sp I got to
chloitopia
who did you kill
5thLeaf
Your ex gf...
chloitopia
good riddance
thanks
5thLeaf
Yea now pay up
chloitopia
oh
meet me in the back street
don't carry weapons
5thLeaf
NO DONT PAY IN SEX
I need money
chloitopia
I'll pay in DEATH
5thLeaf
Why does the government take your taxes just to return them at the end of the year
chloitopia
it does?
5thLeaf
Uh oh I'm getting too smart
In America
chloitopia
idk it send me the thing about getting my tax return I never go
Hi guys @RentableZulu student have 3 diploma:
have an associates in mathematics and science and a bachelors in both biology with a concentration in genetics and biochemistry
1
Its mostly being benfitical to have at least one , a none freelancer biologist
RentableZulu
@ibtisam.midlet thank you for the introduction! I’m grateful to be part of the community and I look forward to collaborating on projects and contributing!
1
ibtisam.midlet
See channels to know what we are researching, if you could contribute will be awesome +_+
Or even get some unusual info might help you
1
RentableZulu
Of course, I’ll be sure to check them out! Thanks again for the intro to the community
Does anyone know how artificial eggs and sperms generate from stem cells even make sense?
Stem cells carry the full number of chromosomes in its DNA, while eggs and sperms only carry half.
ibtisam.midlet
Generated* From stem cells?
If I understanded your question, then stem cells need to splited to get half DNAs like sperm and eggs
In other way if you mean how stem cells can be generated from egg and sperm or not, then just join them and you get full DNA
you can even ganerate full DNA just from half DNA (chromatid) there recessive and dominant genes there, but still not important, you can just use the same chromatid twice
@Damianze
Does anyone know how artificial eggs and sperms generate from stem cells even make sense?
Mabus Tiefsee
for cloning an extinct animal, yeah maybe . For every other practical application, there are better ways
and it always depend on the goal, what do you want to achieve?
CEO
Yo
veganpermanently
CEO of CEO
@veganpermanently
CEO of CEO
diabolik
yo
@diabolik
yo
veganpermanently
Sup
The Blur
veganpermanently
Everybody here
Leave sirsa to die alone
1
The Blur
I heard he likes McDonald’s
@veganpermanently
Leave sirsa to die alone
((odder_sea (glow-worm))
I should have known you were orchestrating this behind the scenes, you diabolical heathen
3
@((odder_sea (glow-worm))
I should have known you were orchestrating this behind the scenes, you diabolical heathen
The Blur
Who is u
@The Blur
Who is u
((odder_sea (glow-worm))
I am the clown with the tear-away face
@((odder_sea (glow-worm))
I should have known you were orchestrating this behind the scenes, you diabolical heathen
chloitopia
thank you for the kind words odder
@chloitopia
thank you for the kind words odder
((odder_sea (glow-worm))
It's is my honor to bestow upon you my encouraging prose
@((odder_sea (glow-worm))
It's is my honor to bestow upon you my encouraging prose
chloitopia
which demon suddenly imbued you with the power of silky smooth lyrical spell mastery
@chloitopia
which demon suddenly imbued you with the power of silky smooth lyrical spell mastery
((odder_sea (glow-worm))
I been spitting these lyrical enigmas since I could remember
@((odder_sea (glow-worm))
I been spitting these lyrical enigmas since I could remember
chloitopia
splitting minds like a sigma, makes me wanna get better
@chloitopia
splitting minds like a sigma, makes me wanna get better
((odder_sea (glow-worm))
Degenerate rhymes, I'm a stigma, tell yo ho ma she can ligma
MEE6BOT
GG @((odder_sea (glow-worm)), you just advanced to level 1!
Netizenne
Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_;
We should probably nook D2/D4 to proactively prevent that imo, they are involved in novelty seeking iirc
But is the novelty seeking of D2/D4 applicable to social relations????
@Netizenne
Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_;
((odder_sea (glow-worm))
Too late, fomenting a coup d'état in Nicaragua
1
@((odder_sea (glow-worm))
Too late, fomenting a coup d'état in Nicaragua
Netizenne
NOOOOO
Blank and Bonk have already left nootopics for greener lands
Such damage has already been done
We need cohesion!!!!!!!
@Netizenne
Blank and Bonk have already left nootopics for greener lands
((odder_sea (glow-worm))
Together? Holding hands?
@((odder_sea (glow-worm))
Together? Holding hands?
Netizenne
B-team
((odder_sea (glow-worm))
Skipping into the sunset?
Netizenne
Ya exact
MEE6BOT
GG @Netizenne, you just advanced to level 2!
@Netizenne
Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_;
chloitopia
r u joking
I'm too autistic to tell
@Netizenne
We need cohesion!!!!!!!
chloitopia
not on Sirsad's server
in general, yeah wouldn't hurt
with a delta male leader eh
@Netizenne
Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_;
Alyen
chloitopia
regarding novelty seeking
@chloitopia
r u joking
Netizenne
Does it matter, there is knowledge to be gained in adopting the narrative and the motivations that come with it
Alyen
Wow u guys are super mods
@Netizenne
Does it matter, there is knowledge to be gained in adopting the narrative and the motivations that come with it
chloitopia
there is no novelty seeking activity more complex than biohacking
@Alyen
Wow u guys are super mods
Netizenne
I will moderate your LIFE
There is no escaping this server
Alyen
Ok
chloitopia
there is always new pathways
and even the old pathways always have new interactions
these people that left the space didn't do so bcs there is no more novelty in biohacking
bcs there always is and it's not even hard to come across it
so you don't even need to seek we're all just showered in novelty
these people left for 2 reasons
they got dissapointed by people or their biohacking success or scared of sides for some reason
Netizenne
Perhaps there is a sweet spot for how much novelty seeking you get.
Or perhaps different pathways effect novelty seeking within different domains -like maybe oxytocin increases novelty seeking within “things” but not people.
@Netizenne
Perhaps there is a sweet spot for how much novelty seeking you get. Or perhaps different pathways effect novelty seeking within different domains -like maybe oxytocin increases novelty seeking within “things” but not people.
chloitopia
seeking new people for the novelty is just low IQ
Netizenne
Idk not really
Meet the right person and you can stumble upon insane wealths of knowledge
chloitopia
well yeah
but you did that for the knowledge not the person
Netizenne
Does novelty seeking, divergent thinking, creativity and aberrant synaptogenesis all have something in common???
chloitopia
can put paranoia in that category
Netizenne
I think sirsad said psychedelics cause massive aberrant synaptogenesis like it was a bad thing, -but aren’t the abnormal/divergent connections of these substances where the creativity comes from???????
chloitopia
just make the brain go brr if u ask me
1
@Netizenne
I think sirsad said psychedelics cause massive aberrant synaptogenesis like it was a bad thing, -but aren’t the abnormal/divergent connections of these substances where the creativity comes from???????
((odder_sea (glow-worm))
Yeah, as long as you don't overdo it, and alternate with pruning protocols, I forsee mostly benefits
Netizenne
How do different dopamine receptors modulate aberrant synaptogenesis ?
Could the novelty seeking of D2 and D4 be considered that?
((odder_sea (glow-worm))
Excited to find that Matrine may be a viable pruning aid, I'll pick some up in a few months with the ND winter sale
@chloitopia
just make the brain go brr if u ask me
Netizenne
brrrrrrrrrrrrerrrrrrrraaaiiiiin
Ya I am not sure about pruning tbh
Is probably necessary but I think you’ve got a limited amount of connections to prune or something maybe
chloitopia
what I'm sure about psychs is that they produced a permanent hallucinatory state for me
I can't say it's bad tho
also I'm sure this state is largely underreported as many users don't even know what it is or that it came from psychs
@Netizenne
Is probably necessary but I think you’ve got a limited amount of connections to prune or something maybe
((odder_sea (glow-worm))
Gets rid of the ones you don't need/reinforce.
Can help with learning new habits/unlearning old habits
Excessive use of neurogenics will probably lead to autism-like cognitive patterns over time
Netizenne
chloitopia
the problem with neurogenesis is that the neurons and synapses start stacking on top of one another
eventually u end up with a smooth brain
so the only way to really get gains is to trepanate and grow another brain outside
heh my pfp finally lived up to it's name
Netizenne
Disintegrins are what enable cancer cells to drill through tissues and invade/connect different regions I think.
Maybe you can grow the brain without it all becoming connected somehow by researching these.
I could be wildly misrepresenting their role tho
Def double check that
chloitopia
today I had the weirdest trip
I stopped riding for a second
had the sensation of falling sideways
then extreme nausea and cold sweats for 20 mins
1
1
kinda like food poisoning
Netizenne
Hmmm that does not seem good lol
chloitopia
ye
weirdest thing is
Netizenne
It’ has been very hot out here lately
chloitopia
after the 20 mins like nothing happened
I can't handle the heat anymore for sure
it's fucking torture
Netizenne
Click to see attachment
Netizenne
It is weird how this model almost suggests autism results from too much pruning tbh ……….
Like there’s something off there
Netizenne
It is weird how this model almost suggests autism results from too much pruning tbh ……….
Netizenne
@Yana
@Netizenne
It is weird how this model almost suggests autism results from too much pruning tbh ……….
chloitopia
wth is that anyways
been staring at it for 2 mins straight
only to notice the title last
@chloitopia
wth is that anyways
Netizenne
They use slime molds to model Tokyo subways system and now they’re using slime molds to mode human cognitive diversity
A siesta (from Spanish, pronounced [ˈsjesta] and meaning "nap") is a short nap taken in the early afternoon, often after the midday meal. Such a period of sleep is a common tradition in some countries, particularly those in warm-weather zones. The "siesta" can refer to the nap itself, or more generally to a period of the day, generally between 2...
MEE6BOT
GG @Netizenne, you just advanced to level 3!
Netizenne
I’ve found I tend to have a midday period where I’ll laze in bed and kinda rest, but I don’t ever go so far as to actually sleep much
Have you noticed that many people wake up with anxiety after an afternoon nap.
@Potential
Have you noticed that many people wake up with anxiety after an afternoon nap.
chloitopia
it's a hit or miss for me
never anxiety
but sometimes it provides rest, sometimes it makes me even more tired
if I have nice dreams it's usually the most rejuvenating
lucid dreaming esp
I feel like the key is to stay conscious throughout the whole thing
@chloitopia
but sometimes it provides rest, sometimes it makes me even more tired
Potential
You have to factor in the circadian rhythm.
I've found with myself that a (max) 30min rest doesn't usually trigger anxiety.
MEE6BOT
GG @Potential, you just advanced to level 2!
chloitopia
total loss of consciousness would be hard to get back from
1
Potential
A combination of L-theanine, Taurine and Phenibut is nice when I really need good quality sleep.
@Potential
You have to factor in the circadian rhythm. I've found with myself that a (max) 30min rest doesn't usually trigger anxiety.
chloitopia
I don't think it's about duration at all. I could sit in meditation for 4 hours and not feel any more tired at all. But if I lose consciousness for more than a single REM cycle it's over
Perioperative neurocognitive disorder (PND) is a serious nervous system complication characterized by progressive cognitive impairment, especially in …
Sleep deprivation (SD) causes oxidative stress in the hippocampus and subsequent memory impairment. In this study, the effect of near-infrared (NIR) photobiomodulation (PBM) on learning and memory impairment induced by acute SD was investigated. The mice were subjected to an acute SD protocol for 72 …
So simply increasing vmat is not good enough, I also need to improve mitochondria in order to provide them the energy to load the vesicles????
What is your treatment doc!!!!????????
@Netizenne
So simply increasing vmat is not good enough, I also need to improve mitochondria in order to provide them the energy to load the vesicles???? What is your treatment doc!!!!????????
chloitopia
indeed
increasing VMAT2 without improving mitochondrial health concurrently will lead to random disorders
throw a dice
shizo
bipolar
((odder_sea (glow-worm))
Elliot Overton has me convinced that a cycle of high dose thiamine, say 500mg+ of the fat soluble forms, is useful for upregulating enzymes/cellular energy.
If you make it a cycle of Sulbutiamine, you can increase D1 dopamine receptors too
@((odder_sea (glow-worm))
Elliot Overton has me convinced that a cycle of high dose thiamine, say 500mg+ of the fat soluble forms, is useful for upregulating enzymes/cellular energy. If you make it a cycle of Sulbutiamine, you can increase D1 dopamine receptors too
chloitopia
u know
the body is not a fat blob
unless you're a fat blob
the brain does accept fat soluble subs via diffusion without transporter action
but the brain is not the only target of thiamine
@chloitopia
increasing VMAT2 without improving mitochondrial health concurrently will lead to random disorders
((odder_sea (glow-worm))
IMO may, if not most, chronic diseases are to some degree mediated by impaired mitochondrial functioning
@chloitopia
the brain does accept fat soluble subs via diffusion without transporter action
((odder_sea (glow-worm))
I'm on board with those points, bit I'm not tracking 100% what you are trying to communicate here
@((odder_sea (glow-worm))
IMO may, if not most, chronic diseases are to some degree mediated by impaired mitochondrial functioning
chloitopia
indeed, as all transporters use cellular energy
@chloitopia
thiamine is an idea u know @Netizenne
Alyen
Ttfd
Oh someone said that
@((odder_sea (glow-worm))
I'm on board with those points, bit I'm not tracking 100% what you are trying to communicate here
chloitopia
just substantiating the stack. btw it's not my invention
the inventor is unknown
eventually I will develop a life-back serum without stims
just instant mitochondrial rockin and poppin
mitochondria go brrrr
Netizenne
sr9009 or PQQ for mitochondria health
@Netizenne
sr9009 or PQQ for mitochondria health
chloitopia
both pls
I'm still hesistant about snorting PQQ
looks both appealing and dangerous at the same time
absolutely no info online
btw prob with sr9009 is the short half life
Netizenne
If I were to start with just 1, pqq is prob safer and more effective right?
chloitopia
u have to dose it every few hours
1
at the very least
@chloitopia
u have to dose it every few hours
Netizenne
Ouch what a pain
@Netizenne
If I were to start with just 1, pqq is prob safer and more effective right?
chloitopia
yes
cheaper as well
@chloitopia
u have to dose it every few hours
Netizenne
I think id probably use it more on a case by case basis in that case, just taking it when I wanna get stuff done
Request PDF | On Aug 1, 2015, B. Chakraborti and others published Positive association of MAOA and VMAT2 with autism spectrum disorder (ASD) in the indian population | Find, read and cite all the research you need on ResearchGate
@Netizenne
I think id probably use it more on a case by case basis in that case, just taking it when I wanna get stuff done
chloitopia
not much acute effect by itself from what I've seen
DJ-1. If u find another DA neuron penetrable compound that prevents DJ-1 oxidation you're golden. DJ-1 is a master regulator of VMAT2 expression. If the transporter is dysfunctional, oxidation rises and DJ-1 acts as a chemical antioxidant. The only way to stop the process is to introduce another antioxidant that is capable of DJ-1 protection which is only PQQ.
@chloitopia
serotonin production and release are dependent on retina light exposure
blank
sometimes I feel a lot more productive if I just spend the whole day in the dark what does this mean
@veganpermanently
DJ-1. If u find another DA neuron penetrable compound that prevents DJ-1 oxidation you're golden. DJ-1 is a master regulator of VMAT2 expression. If the transporter is dysfunctional, oxidation rises and DJ-1 acts as a chemical antioxidant. The only way to stop the process is to introduce another antioxidant that is capable of DJ-1 protection which is only PQQ.
((odder_sea (glow-worm))
Aha. I knew PQQ was OG. Suck it Sirsad
veganpermanently
BTW it's not like people have invented this. PQQ is endogenous and this is it's job in the brain
@veganpermanently
DJ-1. If u find another DA neuron penetrable compound that prevents DJ-1 oxidation you're golden. DJ-1 is a master regulator of VMAT2 expression. If the transporter is dysfunctional, oxidation rises and DJ-1 acts as a chemical antioxidant. The only way to stop the process is to introduce another antioxidant that is capable of DJ-1 protection which is only PQQ.
blank
why hasn't anyone talked about this before
((odder_sea (glow-worm))
How big of a difference are we going to see from IN administration versus oral? What's the Ideal dose for IN and Oral?
I've been using 20mg in the AM with my ALCAR for synergistic effect and to prevent TMAO bacteria from colonizing.
@blank
sometimes I feel a lot more productive if I just spend the whole day in the dark what does this mean
veganpermanently
Probably your 5ht2c is too sensitive to serotonin or you have too much oxidation, your kynurenine pathway is too activated. Dark metabolizes 5HT via AANAT preferentially.
blank
@blank
why hasn't anyone talked about this before
veganpermanently
Bcs I am the VMAT2 God
@((odder_sea (glow-worm))
How big of a difference are we going to see from IN administration versus oral? What's the Ideal dose for IN and Oral? I've been using 20mg in the AM with my ALCAR for synergistic effect and to prevent TMAO bacteria from colonizing.
veganpermanently
I don't recommend IN no one has tried this before
There are no studies either. Unexpected results may occur esp in terms of nasal cavity
@veganpermanently
Bcs I am the VMAT2 God
((odder_sea (glow-worm))
@veganpermanently
I don't recommend IN no one has tried this before
((odder_sea (glow-worm))
Ok. Making sure I wasn't missing the boat on something awesome here. What do you feel is the ideal oral dose/schedule for general purposes?
@((odder_sea (glow-worm))
Ok. Making sure I wasn't missing the boat on something awesome here. What do you feel is the ideal oral dose/schedule for general purposes?
veganpermanently
20 mg
@veganpermanently
20 mg
((odder_sea (glow-worm))
Once daily?
veganpermanently
Yes
Morning
((odder_sea (glow-worm))
And what's your opinion on Ubiquinone/Ubiquinol?
I've been taking them off and on for years, after learning that vegans tend to have lower levels. Currently on 100mg of vitacost ToCoQ10 with tocotrienols and bioperine in the AM, allegedly sun exposure converts it to ubiquinol in the bloodstream. Have some qunol ubiquinol I take on cloudy days
veganpermanently
I like it but it's too expensive. I'd like to do other things with my money now. Maybe when I'm older
((odder_sea (glow-worm))
And were you the one recommending chlorophyll?
I picked up a bunch of chlorophyllin from LEF, allegedly activated by sunlight, some people theorize may assist with production of ATP, but haven't seen anything solid on it. I take 100mg with the ToCoQ10 in the AM
@CEO
Yo
blank
@veganpermanently
I like it but it's too expensive. I'd like to do other things with my money now. Maybe when I'm older
((odder_sea (glow-worm))
I picked up two years worth from vitacost for about $60 on sale
@((odder_sea (glow-worm))
And were you the one recommending chlorophyll? I picked up a bunch of chlorophyllin from LEF, allegedly activated by sunlight, some people theorize may assist with production of ATP, but haven't seen anything solid on it. I take 100mg with the ToCoQ10 in the AM
veganpermanently
I recommend everyone to eat leaves
MEE6BOT
GG @veganpermanently, you just advanced to level 3!
veganpermanently
Chlorophyll is one of the nice parts of leaf tho', holds a few biohacking secrets
@veganpermanently
I recommend everyone to eat leaves
((odder_sea (glow-worm))
I eat tons of greens, But allegedly very little of intact chlorophyll makes it to the bloodstream
@((odder_sea (glow-worm))
I eat tons of greens, But allegedly very little of intact chlorophyll makes it to the bloodstream
veganpermanently
Well the thing is chloroplasts have more than chlorophyll
blank
veganpermanently
I think juicing should release the contents
Wheat grass juice is nice if prepared fresh and well
@veganpermanently
I think juicing should release the contents
((odder_sea (glow-worm))
I wonder if consuming with a bit of Sunflower lecithin may improve uptake?
@((odder_sea (glow-worm))
I wonder if consuming with a bit of Sunflower lecithin may improve uptake?
veganpermanently
Cool idea. Without ultrasonication no but... When life gives you lemons
Make a cake
((odder_sea (glow-worm))
I like to throw a teaspoon In with my green smoothies, I wondered if the vitamin released enough energy to liposomalize any fraction of the nutrients. I was under the impression the lipophyllic/emulsifying nature of lecithin would help with intestinal uptake even if not fully complexed,
MEE6BOT
GG @((odder_sea (glow-worm)), you just advanced to level 3!
veganpermanently
Time to start experimenting with this stuff. Liposomal everything, nano/microemulsions, etc.
Took 1500 mg MgCl yesterday before sleep. Bowel movement is now perfect
I Guess I was deficient
((odder_sea (glow-worm))
I've always wondered if you could make liposomal/PC DHA (Ala krill oil) with algae oil and lecithin via ultrasonic complexing, which may be beneficial for APOE carriers die to their poor transport of non-PC DHA across the BBB
@((odder_sea (glow-worm))
I've always wondered if you could make liposomal/PC DHA (Ala krill oil) with algae oil and lecithin via ultrasonic complexing, which may be beneficial for APOE carriers die to their poor transport of non-PC DHA across the BBB
veganpermanently
PC no, liposomal yes but what this would do IDK
@veganpermanently
PC no, liposomal yes but what this would do IDK
((odder_sea (glow-worm))
I think the AvailOM Algal should accomplish the same feat, so sort of a moot point maybe
@((odder_sea (glow-worm))
I think the AvailOM Algal should accomplish the same feat, so sort of a moot point maybe
veganpermanently
ALA is superior anyways
@veganpermanently
ALA is superior anyways
((odder_sea (glow-worm))
I know some if the literature suggests this, though I've always been concerned about relying on endogenous conversion for DHA, mostly from the positive studies of DHA intervention (though individuals were almost certainly not vegans)
Related, I've seen it referenced that curcumin, and I think longvida specifically, may increased endogenous conversion of ALA into DHA in the brain
But also that the conversion is fairly oxidative in nature, so may result in excess ROS compared to exogenous, pre-formed DHA
As in, 10 units of ALA have to be oxidized to get 1 unit of DHA. I'll try to find the source on that
For many years I was having several teaspoons per day of Flax/Chia, but slightly concerned about anti-androgenic effects of flax, as I'm (or was, last time I was checkedbtwo years ago) borderline low-T High-E
@((odder_sea (glow-worm))
But also that the conversion is fairly oxidative in nature, so may result in excess ROS compared to exogenous, pre-formed DHA As in, 10 units of ALA have to be oxidized to get 1 unit of DHA. I'll try to find the source on that
chloitopia
it doesn't matter. the compounds themselves are antioxidants so this reaction is actually protecting everything else from oxidation. It's like saying don't take PQQ because it oxidizes. Of course it does - it's an antioxidant
@((odder_sea (glow-worm))
For many years I was having several teaspoons per day of Flax/Chia, but slightly concerned about anti-androgenic effects of flax, as I'm (or was, last time I was checkedbtwo years ago) borderline low-T High-E
chloitopia
dietary phytoestrogens will not influence endogenous hormone levels. If anything they should reduce estrogen, but they don't
but. it's probably best to get an oil press and press your own oil from flax, not for the phytoestrogens but the cyanogenic glycosides. A few teaspoons will not be toxic but if you want real gains from ALA you need to press it
@chloitopia
dietary phytoestrogens will not influence endogenous hormone levels. If anything they should reduce estrogen, but they don't
((odder_sea (glow-worm))
I don't believe that Flax's anti-androgenic effects were mediated primarily by phytoestrogen.
I consider phytoestrogens to be generally positive for men and women
chloitopia
why not just buy flax oil? it oxidizes quickly when it's not protected by the seed shell. You need to consume it within 4 hours of pressing. Which is why homepress is best. It's also the cheapest, tho' the upfront cost is about 300 USD.
@chloitopia
why not just buy flax oil? it oxidizes quickly when it's not protected by the seed shell. You need to consume it within 4 hours of pressing. Which is why homepress is best. It's also the cheapest, tho' the upfront cost is about 300 USD.
((odder_sea (glow-worm))
I normally just used flax ground at home In a coffee grinder- the ALA is stable for over 6months at room temperature, which was irrelevant as I'd keep it in the fridge in a Mason jar and make a new batch every few weeks
@((odder_sea (glow-worm))
I normally just used flax ground at home In a coffee grinder- the ALA is stable for over 6months at room temperature, which was irrelevant as I'd keep it in the fridge in a Mason jar and make a new batch every few weeks
chloitopia
yes even when ground it is stable because the shell contains antioxidants, but when you separate the oil it oxidizes within hours
@Netizenne yo this is what I was talking about the other day
why do people DM me with small talk
do I appear like such a person
'hey dude'
'what's good bruh'
@chloitopia
yes even when ground it is stable because the shell contains antioxidants, but when you separate the oil it oxidizes within hours
((odder_sea (glow-worm))
Yeah, and all the fiber benefits/blood sugar mitigating effects are from the ground seeds, not the oil
@chloitopia
'hey dude' 'what's good bruh'
blank
I feel like those are spam accounts
I've actually tried to talk to them a few times and they are unable to do so and just keep repeating small talk phrases
((odder_sea (glow-worm))
Imma start doing that again, Aldi's sells the seeds for dirt cheap. Adding a tablespoon to every meal/smoothie
Really good for giving a smoothie a thick. Ice-creamy texture
@blank
I've actually tried to talk to them a few times and they are unable to do so and just keep repeating small talk phrases
chloitopia
I don't even know what to respond in the case it's a real person
blank
ask them if they have done anything interesting recently
MEE6BOT
GG @blank, you just advanced to level 2!
blank
usually shuts them up
@blank
ask them if they have done anything interesting recently
chloitopia
I asked if it was a bot
@((odder_sea (glow-worm))
Really good for giving a smoothie a thick. Ice-creamy texture
chloitopia
yes I prepare a smoothie like this every day:
200 g Banana
200 mL Soy milk
20 g Flax seed
30 g Chia seed
3 g Ceylon Cinnamon
Water until consistency is desireable
I omit the ceylon and soy milk while fasting mimicking and use just 1 banana. less seeds as well
@chloitopia
yes I prepare a smoothie like this every day: 200 g Banana 200 mL Soy milk 20 g Flax seed 30 g Chia seed 3 g Ceylon Cinnamon Water until consistency is desireable
((odder_sea (glow-worm))
Do you pre-grind the flax?
@blank
ask them if they have done anything interesting recently
chloitopia
he said he's not a bot, he comes in peace and proceeded with the small talk
@chloitopia
he said he's not a bot, he comes in peace and proceeded with the small talk
((odder_sea (glow-worm))
Kill it with fire
@((odder_sea (glow-worm))
Do you pre-grind the flax?
chloitopia
yes in a coffee grinder
I love it how my reddit karma keeps going up and down
it's more an issue that cars stop for you even when they wouldn't have needed to and you awkwardly walk in front of them while they are stopped
but I'm glad it be this way
like here the second car already would have stopped and maybe even the first car on a weird day
@blank
it's more an issue that cars stop for you even when they wouldn't have needed to and you awkwardly walk in front of them while they are stopped
chloitopia
there's a law here that states a cyclist needs to get off the bike when crossing a zebra. but cyclists are not allowed to ride on the pedestrian pavement. so you know how fucked up it is
@blank
it's more an issue that cars stop for you even when they wouldn't have needed to and you awkwardly walk in front of them while they are stopped
Netizenne
Lol same
Sometimes I’ll wait to J-walk and the car will stop even though there’s no intersections or crosswalks lmfao
So instead I just have to really slowly walk or pose like I’m not waiting on traffic to cross xdddd
1
chloitopia
there is an obvious contradiction in law
Netizenne
I always get mad inside “like wtf!!! You have the right of what wtf are you doing!!!?!???”
@Netizenne
Lol same Sometimes I’ll wait to J-walk and the car will stop even though there’s no intersections or crosswalks lmfao So instead I just have to really slowly walk or pose like I’m not waiting on traffic to cross xdddd
chloitopia
it's like you're living in a GTA city
@chloitopia
it's like you're living in a GTA city
Netizenne
Ya lmao ig
chloitopia
usually the traffic is fine here but not because of law
but because the people have unwritten rules they stand by
mostly respect and logic
but one fool is enough to throw my mood off for the whole day
it's mostly Bosnians roflmao
@chloitopia
usually the traffic is fine here but not because of law
Oral hydroxycitrate supplementation enhances glycogen synthesis in exercised human skeletal muscle - Volume 107 Issue 7
if someone has more ideas lemme kno
@chloitopia
I am VP dude
((odder_sea (glow-worm))
How many alts you got bruh
Potential
@chloitopia It seems that we are neighbours.
I find the interactions between former nations of Yugoslavia intriguing to say the least. So much pride everywhere.
((odder_sea (glow-worm))
Is this a whole server of VP arguing with himself with different avatars?
1
1
chloitopia
((odder_sea (glow-worm))
@Potential
@chloitopia It seems that we are neighbours. I find the interactions between former nations of Yugoslavia intriguing to say the least. So much pride everywhere.
chloitopia
I don't have pride about my people, I feel pity if anything. I feel we suffered greatly historically. All of the nations here. Our true cultural identities are stolen. I have pride about where we all come from, pride about this geographical space, it's very special
what I said about Bosnians and road, they don't understand things in Zagreb don't work according to law. Common sense needs to be applied for everything to work smoothly
if they spend some time here eventually they realize how things work
it's not about them, it's about the cultural shock. all minorities are like this it's just that the Bosnians are the most frequent minority
Butyrate is an abundant metabolite produced by the gut microbiota and is known to modulate multiple immune system pathways and inflammatory diseases. However, studies of its effects on virus infection of cells are limited and enigmatic. We found that butyrate increases cellular infection and virus replication in influenza virus, reovirus, and hu...
something to be considered regarding all dietary interventions
Interesting. I was peaked in interest on BHT as it is alleged to supress herpes viruses, and I am swayed by the viral theory of alzheimers (though as a degenerative symptom, rather than the root cause)
@((odder_sea (glow-worm))
Interesting. I was peaked in interest on BHT as it is alleged to supress herpes viruses, and I am swayed by the viral theory of alzheimers (though as a degenerative symptom, rather than the root cause)
Pan-histone deacetylase (HDAC) inhibitors, which inhibit 11 HDAC isoforms, are widely used to induce Epstein-Barr virus (EBV) lytic cycle in EBV-associated cancers in vitro and in clinical trials. Here, we hypothesized that inhibition of one or several specific HDAC isoforms by selective HDAC inhibi …
the most interesting thing you can use it to chase out the virus and kill it
I feel like everything I take is making my face look younger by the day but I still have acne problems due to excessive sebum secretion
does anybody have biohacks against this other than the retinoids
@chloitopia
the most interesting thing you can use it to chase out the virus and kill it
((odder_sea (glow-worm))
@chloitopia
I feel like everything I take is making my face look younger by the day but I still have acne problems due to excessive sebum secretion
((odder_sea (glow-worm))
Ditching most processed oils from my diet gives me zero facial acne and great skin
@((odder_sea (glow-worm))
Ditching most processed oils from my diet gives me zero facial acne and great skin
chloitopia
IG I could try that. I still use olive oil and pumpkin seed oil
makes the dishes way better
the prob is I've inherited this sebum secretory skin from my mother
she still has acne sometimes at nearly 60 yrs old
((odder_sea (glow-worm))
I only use a dash of olive oil (Sirtuin activator) and a few caps of NCT with my morning coffee/tea, and some algae oil at night.
Other than that, it's Carbs carbs, carbs
@((odder_sea (glow-worm))
I only use a dash of olive oil (Sirtuin activator) and a few caps of NCT with my morning coffee/tea, and some algae oil at night. Other than that, it's Carbs carbs, carbs
chloitopia
I think it's key to separate the oils from the carbs
I notice instant sebum secretion when I consume a meal that's high in both
@chloitopia
I think it's key to separate the oils from the carbs
((odder_sea (glow-worm))
Def don't play well together.
I love Olive oil, there's a great Grove nearby I need to check out.
But at the end of the day, it's just fat
I'm trying to maximize insulin sensitivity and cut bodyfat
chloitopia
indeed. omega 9 increases sebum secretion
@((odder_sea (glow-worm))
I'm trying to maximize insulin sensitivity and cut bodyfat
chloitopia
use my protocol
you will cut within days
@chloitopia
use my protocol
((odder_sea (glow-worm))
What's your prootocol
Bro
@((odder_sea (glow-worm))
What's your prootocol
chloitopia
u don't know
omg
((odder_sea (glow-worm))
IDK sheet
chloitopia
there's a lot to be said
((odder_sea (glow-worm))
Lay it on me you Croatian MF'er
chloitopia
I modified it. omitted the memantine and DHF for optimal neuronal pruning
1st day 1200 kcal 40 g protein 2nd-5th day 725 kcal and 30 g protein
light endurance exercise as much as possible, without strenous activity
when you refeed don't introduce food in 500 kcal increments per day. do not bring in more at once it will cause hyperglycemia. space out the meals as much as possible in the insulin sensitive window
which is 9 AM to 2 PM and 3PM to 6 PM
subL matcha is essential for optimal visceral fat targeted weight loss. also improves fasting tolerance i.e. reduces hunger
will make you a bit nauseous if you do it food a few hours after you take it tho
so do it first thing in the morning and around 1 o clock PM
the original protocol is by Valter Longo I have only build upon it
he is a true genius no other doctor like him on the planet
will play more with the protocol, I think B vitamins may be key here.
btw the addition of Rapamycin may have caused too much autophagy and apoptosis. I had a headache and muscle pains on day 3 last time I did it. Stimulation followed by weakness, had to take a nap
@chloitopia
subL matcha is essential for optimal visceral fat targeted weight loss. also improves fasting tolerance i.e. reduces hunger
((odder_sea (glow-worm))
Would EGCG or Green Tea phytosome have the same effect?
@((odder_sea (glow-worm))
Would EGCG or Green Tea phytosome have the same effect?
chloitopia
likely yes, but only with caffeine
caffeine + EGCG have synergistic anorectic effects
((odder_sea (glow-worm))
I usually take with caffeine, such as organic coffee, Fresh green yerba mate, and or guayusa
chloitopia
nice
btw don't do this too often. it will be stressful on the psyche first time you do it
((odder_sea (glow-worm))
I have a bunch of the green-tea phytomse from science.bio shutdown.
I have a bag of Jade leaf matcha, but I try to limit my green tea intake due to flouride concerns
chloitopia
body and brain literally sense famine incoming
which is exactly the point of this
to signal repair and optimization
((odder_sea (glow-worm))
I've been doing calorie restriction/IF vegan for years
Its been a while since I've done a proper 72hr plus fast
chloitopia
yeah calorie restriction is not as effective in my and Longo's opinion
@((odder_sea (glow-worm))
Its been a while since I've done a proper 72hr plus fast
chloitopia
takes 3 days to enter true autophagy.
((odder_sea (glow-worm))
I think protein, or more specifically Leucine/methionine restriction is generally superior
chloitopia
I don't recommend true fasting because it can cause electrolyte imbalances and hypoglycemia followed by the extreme hyperglycemic state when refed
this can be life threatening
@chloitopia
I don't recommend true fasting because it can cause electrolyte imbalances and hypoglycemia followed by the extreme hyperglycemic state when refed
((odder_sea (glow-worm))
I'd like to try for 5 days with NAD+ and senolytics at some point
chloitopia
your vitals need to be monitored
((odder_sea (glow-worm))
Might be a good time to reset my caffeine tilerance
@((odder_sea (glow-worm))
I'd like to try for 5 days with NAD+ and senolytics at some point
chloitopia
just try the FMD you will be convinced the benefits are the same, yet the risks are greatly diminished
there is no reasoning to do a true fast after Longo's work
@chloitopia
Click to see attachment
((odder_sea (glow-worm))
You did show me this one before, the FMD cronometer
chloitopia
it should be a thing of the past now
@chloitopia
light endurance exercise as much as possible, without strenous activity
((odder_sea (glow-worm))
Would multiple hour walks suffice for this?
chloitopia
I don't think humans have ever historically fasted at all, there was always some food to it, but it was limited at times
@((odder_sea (glow-worm))
Would multiple hour walks suffice for this?
chloitopia
indeed
@chloitopia
indeed
((odder_sea (glow-worm))
That's my antidepressant of choice
I hadn't watched Longo interview or reviewed much of his literature
@((odder_sea (glow-worm))
That's my antidepressant of choice
chloitopia
mine is cycling. my walking parts of the brain have withered away. I even cringe a little when I see people walk roflmao
@chloitopia
mine is cycling. my walking parts of the brain have withered away. I even cringe a little when I see people walk roflmao
((odder_sea (glow-worm))
Randomly went on a 6 hour walk the other day
chloitopia
sometimes I choose to walk to the store
feels extremely awkward
like I'm a demon that just took control of a new host
@chloitopia
like I'm a demon that just took control of a new host
((odder_sea (glow-worm))
Your alts are starting to make more sense
chloitopia
he's not wrong
but his solution is
people need to ride bikes
quite simply. laziness needs to be nooked with chemicals
@chloitopia
Click to see attachment
((odder_sea (glow-worm))
@((odder_sea (glow-worm))
Click to see attachment
chloitopia
Amsterdam everywhere please
((odder_sea (glow-worm))
The Segway guy was onto something IMO
Bike speeds in a walking footprint
@((odder_sea (glow-worm))
Bike speeds in a walking footprint
chloitopia
wut
@chloitopia
wut
((odder_sea (glow-worm))
MEE6BOT
GG @((odder_sea (glow-worm)), you just advanced to level 5!
((odder_sea (glow-worm))
Great solution for urban mobility, of there was sufficient adoption/infrastructure created with them in mind.
However due to the cost and stigma, they remain niche
@((odder_sea (glow-worm))
Click to see attachment
chloitopia
ye I know what a segway is. it's less safe compared to a non-electric bike, has a way higher footprint, burns almost no calories at all
also you look like a dork
@chloitopia
ye I know what a segway is. it's less safe compared to a non-electric bike, has a way higher footprint, burns almost no calories at all
((odder_sea (glow-worm))
Wdym by footprint?
@chloitopia
also you look like a dork
((odder_sea (glow-worm))
That's the stigma
@((odder_sea (glow-worm))
Wdym by footprint?
chloitopia
ecological footprint. it still uses lithium batteries, requires a computer, etc.
@chloitopia
people need to ride bikes
blank
And cities need to have everything necessary in a few km range
average lifetime of Segway and electric scooters is abysmal compared to a bicycle. esp if it steel or aluminum
@chloitopia
ecological footprint. it still uses lithium batteries, requires a computer, etc.
((odder_sea (glow-worm))
Yup
chloitopia
I have an aluminum frame now. as soon as I kill it somehow I'm getting a stainless steel bike and keeping it for life
@blank
And cities need to have everything necessary in a few km range
chloitopia
not really people just need to become stamina beasts they really are again
takes me 30 mins to cross 10 km easily.
we are made for bicycles. feet are fucked up. but legs are optimal
hence we can barely run without getting injured
but anyone can ride a bike as long as their mitochondrion are functional
and the best thing is, riding a bike makes the mitochondrion functional
1
so it's a self fulfilling prophecy in a way
((odder_sea (glow-worm))
I've had an aluminum felt for years. Done many a repairs to keep it chugging.
It's a mountain bike frame that I put road tires on, and allows me to lock out the front shocks on road, and I can swap in my offroad tires if I want to hit trails
chloitopia
blank I read your stylized username like a retarded brit would pronounce the word blunt while spitting saliva in your face
((odder_sea (glow-worm))
Sadly I trashed my knee years ago from commuting by bike too much, I think I have a cyst on my left IT band and wayy advanced arthritis for my age
@chloitopia
blank I read your stylized username like a retarded brit would pronounce the word blunt while spitting saliva in your face
blank
@((odder_sea (glow-worm))
Sadly I trashed my knee years ago from commuting by bike too much, I think I have a cyst on my left IT band and wayy advanced arthritis for my age
chloitopia
IDK what's your exact problem with the knees but biking did not cause it
if you push too hard you can fuck up your knees
if you do drops you will fuck up your knees
if your bike is too small you will fuck up your knees
if your pedals are too close together for your hip size it will fuck up your knees
if you know how to ride and did a proper bike fit, you will not fuck up your knees
in fact it will heal your knees
I had many knee accidents in my life and biking has always improved it and got me back on track
@chloitopia
IDK what's your exact problem with the knees but biking did not cause it
((odder_sea (glow-worm))
I was commuting 15 miles per day for years along with recreation riding. I left work and was pedaling hard and felt a pop, never been the same since.
Had a bunch of MRI's and x-rays, orthopedic surgeons Saud there wasn't much they could do
chloitopia
yeah you got humbled I guess
((odder_sea (glow-worm))
Told me I'll need a knee replacement, eventually diuble
However
chloitopia
I ride at high speeds but never push
build up the speed slowly
((odder_sea (glow-worm))
I yhink I'll try to Find a doc whose willing to do arthroscopy
And then start on Stem cells and rehab
chloitopia
have u trialed bpc
((odder_sea (glow-worm))
I don't want bionic parts. I wanna fix my OEM
@chloitopia
have u trialed bpc
((odder_sea (glow-worm))
I have two Nasal sprays from science.bio, considered injecting
chloitopia
nasal spray delivery is often suboptimal
injecting is best
but be careful. talk to Cogmetics. he has some things against it
I never had the need to do it so never really researched it well
@((odder_sea (glow-worm))
I don't want bionic parts. I wanna fix my OEM
blank
bionic legs though
chloitopia
btw I slept like a baby. had a dream in which a random person I know tried to mog me for money with some gang members. I tricked them with word play they left
blank
@chloitopia
btw I slept like a baby. had a dream in which a random person I know tried to mog me for money with some gang members. I tricked them with word play they left
((odder_sea (glow-worm))
Busting rhymes on these ninjas
@((odder_sea (glow-worm))
Busting rhymes on these ninjas
chloitopia
Monkey Island vibes
@chloitopia
but be careful. talk to Cogmetics. he has some things against it
((odder_sea (glow-worm))
Uxkull got depressive symptoms IIRC
@((odder_sea (glow-worm))
Uxkull got depressive symptoms IIRC
chloitopia
well not a very trustworthy source on anecdotals kek
but there's more. Cog knows more
@ibtisam.midlet would u like to introduce this emoji. I can edit it for the transparent bg
Metabolic Brain Disease - Schizophrenia is a debilitating mental illness. Levels of oxytocin have been proposed as a biomarker of schizophrenia; however, the observed levels of oxytocin in...
blank
suspicious
@blank
suspicious
chloitopia
u have too much oxytocin bruh
@chloitopia
u have too much oxytocin bruh
blank
I used to be really autistic though
ibtisam.midlet
@chloitopia there is no place, do you have GIF emojis?
blank
chloitopia
it really explains a lot about shizotypal minds considering the effects of oxytocin on outgroup aggression
blank
this emoji is duplicated
and discord has it's own flag emojis so they could just be removed
@blank
ibtisam.midlet
I forget to stole this
blank
2 different fire emojis too
chloitopia
Pepe is the best
@blank
and discord has it's own flag emojis so they could just be removed
ibtisam.midlet
That's Unicode 9.0 before google start getting crazy
"... and the forces of darkness will applaud me as I STRIDE through the gates of hell carrying your head on a pike!" ―Murray Murray is a Demonic Skull that terrorized Guybrush Threepwood who first appeared the Curse of Monkey Island. He was originally part of LeChuck's Army of the Undead, before losing his entire skeletal body, and becoming some...
blank
MEE6BOT
GG @blank, you just advanced to level 3!
chloitopia
if the user knows the context it's even more effective
Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms associated with schizophrenia. mGluR5 plays an important role in both long term ...
Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.
An interesting side effec...
There a protein that cause your PFC to detect triggers, some people have upregulation in it causing them to be highly reapornsive to placebo/CBT/sensitive to feel rewards, this type of thing inculding placebo in reality not something that not exist , it is product geniunly real effect
This will keep you from pissing clear every 2 minutes
@Yana
This will keep you from pissing clear every 2 minutes
chloitopia
actually it has a diuretic effect until I develop tolerance. this seems to correlate with the negative mood effects
@chloitopia
actually it has a diuretic effect until I develop tolerance. this seems to correlate with the negative mood effects
Yana
Do you develop "tolerance" to anything else besides the endocrine vasopressin effect
@Yana
Do you develop "tolerance" to anything else besides the endocrine vasopressin effect
chloitopia
it appears not. this sucks because my regimen calls for cycling of citicoline one week on one week off. this brings the tolerance back to normal which is bad because it means I'll be fucked up for half of the week
I cycle it because of TMAO bacteria die off
@chloitopia
I cycle it because of TMAO bacteria die off
Yana
Could you wage a perpetual war with some kind of probiotic?
Also wait you're saying having elevated antidiuretic hormone has a diuretic effect?
@Yana
Could you wage a perpetual war with some kind of probiotic?
chloitopia
there is too litle info on this sadly. microbiome is largely a mystery. What we do know is that in absence of dietary choline and carnitine these bacteria die off or change their metabolic preferences as shown by the reduced TMAO levels in vegetarians. upon introduction of choline after a week they had the same TMAO levels as omnis
@Yana
Also wait you're saying having elevated antidiuretic hormone has a diuretic effect?
chloitopia
this is because of the MoA of release.
choline is diuretic itself and the effect appears stronger than the vasopressin release it causes
so it's not that the elevated vasopressin causes a diuretic effect, it's just that CDP choline has a diuretic effect DESPITE the vasopressin release
1
btw look into the cholinergic syndrome prophylaxis
@chloitopia
choline is diuretic itself and the effect appears stronger than the vasopressin release it causes
Yana
ok ok so it's this you're developing tolerance to?
chloitopia
aCh is a potent secretagogue of everything that comes out of the human body
@Yana
ok ok so it's this you're developing tolerance to?
chloitopia
yes after about 3 days my pissing habits are back to normal
depending on the rest of the supplementation, hydration and diet ofc
the negative mood effects are also gone after 3 days
I can tolerate people again
it's not like I ever like them tho
ibtisam.midlet
Isn't colinagic is depressive due to muscarine receptors antagonists being drug of abuse
And produce euphoria
I'm longterm user of tehyrexphynodyle
its ultimately develop tolerance where you need to take it once every 23 days to works
chloitopia
it's multimodal probably.
ibtisam.midlet
And tolerance develop for euphoria but not for cognitive decline
So if you analyzed this exp in opposite way
Then agonists will enhance cognition and decrease mood
But evenatly you will get just enchantment in cognition
chloitopia
I think muscarinic activation prevents you to unsee the bad aspects of your own life. So the cognition improving aspect and the decrease in mood is the same thing
but after a while it is easier to tolerate the negative affect
ibtisam.midlet
Yeah I thinged about that
@ibtisam.midlet
I'm longterm user of tehyrexphynodyle
chloitopia
what is this
ibtisam.midlet
It might control neuron that its job is transmittion of bad memory
chloitopia
yes rumination is exceptionally easy when muscarinic receptors are activated, but more than anything, it is easier to recognize bad intentions of other people which generates a negative worldview quickly
if everyone around you is ill-intended your life cannot be good logically
but these are not schizotypal semidelusions, they're realistic examinations of other people
look at wiki page of negative affect
ibtisam.midlet
The same problem in memoriesing by M1-5 and understanding of D2
chloitopia
people with high negative affect are nearly immune to deception
ibtisam.midlet
Both decrease mood
In way or other
chloitopia
also people with negative affect are less likely to discriminate against other races for example
@chloitopia
people with high negative affect are nearly immune to deception
ibtisam.midlet
Nice
chloitopia
so in my opinion high negative affect is optimal
but an optimistic worldview needs to be maintained
because this is correlated to overall life success
1
problem is that these two are negatively correlated
so we need to break the correlation between negative affect and pessimism somehow
ibtisam.midlet
you are thinking like I does
1
Thinking after the point where other people stop
chloitopia
we're gonna burn the world and grow a new one
@chloitopia
so we need to break the correlation between negative affect and pessimism somehow
ibtisam.midlet
I almost did the samething for daltafos b
Eventually found he relay on nmda association to know what drugs caused euphoria
@ibtisam.midlet
I almost did the samething for daltafos b
chloitopia
my expression is probably very high
I'm addicted to cycling
ibtisam.midlet
Then he start unfair selective agreement generation advocate drug use
Block nmda and your unawareness can't know THC sigarrt is the cause
chloitopia
I believe the evolutionary usecase of delta fos B is to stimulate locomotor activity and make it hurtful for the organisms to stay still for too long
ibtisam.midlet
No drug cue
chloitopia
yes I recovered from THC addiction with memantine
but it did not decrease propensity for exercise
@chloitopia
I believe the evolutionary usecase of delta fos B is to stimulate locomotor activity and make it hurtful for the organisms to stay still for too long
ibtisam.midlet
I found dalta fos be help me in getting addicted to coding
It make it less anxious and more pleasurable by decreasing aversion and doing rewards sensitization
Almost year and half ago I made experiment on codiene
Took 2 doses 120mg
chloitopia
of amph?
ibtisam.midlet
Then waited to see how much craving need to faded
chloitopia
oh codeine
ibtisam.midlet
I found that I needed 4 months to forget how opiates look like
chloitopia
I thought you meant coding
opiates cause no behavioral sensitization for me
they cause negative mood states
ibtisam.midlet
With a half life like this , daily intake will accumulate craving to point having enough dominance to change your opinion
@chloitopia
they cause negative mood states
ibtisam.midlet
What's is this opiate
chloitopia
dysphoria with a large decrement in attention and overall cognition
but I tried heroin only
ibtisam.midlet
People who took hero always not like it first time
Don't try it again
chloitopia
I won't it was an accident
ibtisam.midlet
microdosing codeiene and multi substance formula I talked about was not addictive
chloitopia
thought it was just cannabis
ibtisam.midlet
I took 7.5mg /d for 2 month
blocked depandance in silent phrase by topiramat
@ibtisam.midlet
blocked depandance in silent phrase by topiramat
chloitopia
never knew about that drug it's amazing
ibtisam.midlet
I'm trying to find the study
Anyway
Its ampa antagonist
Aftee you stop opiates there 3 days
Where opiates in not in your system but you still did not get withdrewal
Its called sielnt phrase
In this phrase amap work I'm encoding level which we don't know shit about
To prepare need for withdrawnl execution (some types of depandance not all)
Then their job end and signal transfired to nmda who will execute it
Blocking ampa in sielnt phrase block withdrewall symptoms
Or you will need long term usage of nmda antagonist (21days) for switching bad emotions off
21 due to median need practice for humans to gain habit is 21days
Which depende on nmda and habit not always being good and not always awerness mediated, its just sometype of plasticity
This type of research called biotuning and there group of people like biohackers for it
chloitopia
biotuners
more accurate compared to biohackers
ibtisam.midlet
They analyze things in biological manner without using computional neuroscience, which will cause you to not understand anything lol
chloitopia
behavioral experiments?
ibtisam.midlet
Mean what
?
Don't mention CBT
chloitopia
I mean take one substance which is a known agonist of some receptor, take another substance, if it potentiates effect it's a PAM, if it has additive effects it's another agonist and if it cancels effect it's either an inverse agonist or antagonist
for example
ibtisam.midlet
Need a lot of cycling time
chloitopia
obviously these experiments are confounded by many things such as enzymatic interaction, indirect receptor activity, etc.
unrelated activities may produce similar behavioral effects as well
ibtisam.midlet
mmm yeah pregabaline opiates
@ibtisam.midlet
mmm yeah pregabaline opiates
chloitopia
IMO these studies are mostly sufficient after thorough in vitro binding activity testing
but there are always unknown or untested receptors, enzymes, transporters, even modulation of gene expression
@ibtisam.midlet do you have ideas for safety testing without animals?
@chloitopia
@ibtisam.midlet do you have ideas for safety testing without animals?
Yana
Supercomputing/AI until full-brain/full-organism in silico modeling
It can happen
@Yana
It can happen
chloitopia
Can happen is not enough for it to happen tho'
everything that can go wrong will go wrong eventually
but everything that can go right will rarely go right without intervention
Yana
Maybe biohack to get superhuman regeneration ability so we can give ourselves organ failure etc. and just replace it
2
MEE6BOT
GG @Yana, you just advanced to level 2!
@chloitopia
@ibtisam.midlet do you have ideas for safety testing without animals?
ibtisam.midlet
Taking D3 antagonist and willing to not increase dose more then 25% par day
@Yana
Maybe biohack to get superhuman regeneration ability so we can give ourselves organ failure etc. and just replace it
chloitopia
if I was the other sex I would be hot and moist listening to your fantasies
The expression of IL-1 is elevated in the CNS in diverse neurodegenerative disorders, including Alzheimer's disease. The hypothesis was tested that IL-1 beta renders neurons vulnerable to degeneration by interfering with BDNF-induced neuroprotection. In trophic support-deprived neurons, IL-1 beta co …
interleukinss have the most annoyingly complex interaction with everything
even tissue selective modulation is largely unusable becuse of this
we need time selective modulation for the whole inflammasome it seems however this would require a higher understanding of biomarkers we can use to see if inflammation is necessary at all
I’m actually not able to find a study on oxytocin levels in autist’s cerebral spinal fluid -they’ve all stuck to testing blood/serum levels.
Honestly it never made sense that oxytocin would be low in autists considering oxytocin promotes a slow life history strategist phenotype -and that autism (imo) seems to be an exemplary slow life history strategist phenotype.
But I could be wrong about autism == slow life history strategist phenotype -I’ve heard claims of the contrary.
Also autism and schizophrenia share a lot of similarities, having even been considered the same disorder at one point too.
@ibtisam.midlet do you have ideas for safety testing without animals?
blank
Homeless people
chloitopia
I feel superhuman
people on the internet are constantly telling me what I'm doing is impossible
1
maybe internet people are just pussies tho'
delta males getting mad about other man's modest success
1
ibtisam.midlet
Congrats
@ibtisam.midlet
Congrats
chloitopia
thanks?
@chloitopia
Click to see attachment
Yana
3 different sneeds? Part bird for sure
Thinking about basically replacing milch with lentil soup, kale, and calcium carbonate, but I think I can count on one hand the amount of times I've had legumes or leafy greens in my life
That's so much iron, manganese, and folate dawg
I need some deferoxamine
1
ibtisam.midlet
Buy it?
I think 50mg would be good dose
Yana
I'll add it to the potato water
@chloitopia
I am still mesmerized by the fasoracetam ADHD study
((odder_sea (glow-worm))
Something I should look into? I'd like non-stim options for ADD
Message could not be loaded.
((odder_sea (glow-worm))
I've been wondering about this, as I take 600mg of ALCAR and 85mg of citicoline most days.
I tend to combine with PQQ, resverateol and a teaspoon of EVOO to hopefully mitigate TMAO conversion, and itherwise eat a high fiber plant-based diet, But I wonder what else can be done to inhibit TMAO and the pathogenic bacteria that produce it
@chloitopia
maybe internet people are just pussies tho'
Netizenne
Tbh :/
@((odder_sea (glow-worm))
Something I should look into? I'd like non-stim options for ADD
chloitopia
yes you should look into it. but before trying it get gene testing. it's too expensive to be a hit or miss.
@((odder_sea (glow-worm))
I've been wondering about this, as I take 600mg of ALCAR and 85mg of citicoline most days. I tend to combine with PQQ, resverateol and a teaspoon of EVOO to hopefully mitigate TMAO conversion, and itherwise eat a high fiber plant-based diet, But I wonder what else can be done to inhibit TMAO and the pathogenic bacteria that produce it
chloitopia
dudeee u dropped the L to lowercase. AICAR is another substance.
1
@chloitopia
yes you should look into it. but before trying it get gene testing. it's too expensive to be a hit or miss.
((odder_sea (glow-worm))
TL;DR on the genes in question? I've already been tested
chloitopia
you won't get any TMAO from that stack
@((odder_sea (glow-worm))
TL;DR on the genes in question? I've already been tested
Nature Communications - Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting...
Working memory is a form of short-term memory that involves maintaining and updating task-relevant information toward goal-directed pursuits. Classical models posit persistent activity in prefrontal cortex (PFC) as a primary neural correlate, but emerging ...
@chloitopia
vegan diet is naturally full of iron chelators
((odder_sea (glow-worm))
I've been taking Primavie Shilajit, which I suspect helps protect from anemia
But IMO borderline insufficient iron stores are superior to excess iron, by a long shot
GPR12 is a G protein-coupled orphan receptor genetically related to type 1 and type 2 cannabinoid receptors (CB[1] and CB[2] ) which are ancient proteins expressed all over the body. Both cannabinoid receptors, but especially CB[1] , are involved in ...
indeed, less oxidation, esp in dopaminergic neurons which is important for Parkinson's prevention
((odder_sea (glow-worm))
I think excess iron is also involved in lipofuscin and amyloid plaques.
@Netizenne
Novel targets are cool cause we might accidentally find a new way to get high if we’re lucky loool
chloitopia
I did find a new way to get high but I can't disclose it because the community is a shithole stealing novel substances to make money. Whoever doesn't steal likes talking and it eventually ends up with Sirsad
I won't be a psychedelic Nikola Tesla. My fate is to be crowned as the toad king
@chloitopia
I won't be a psychedelic Nikola Tesla. My fate is to be crowned as the toad king
((odder_sea (glow-worm))
@((odder_sea (glow-worm))
Click to see attachment
chloitopia
Funny thing I had a CEV the other day of a unicorn prince fetus. He was pretty, shiny and cute
gotta make it with MJ
͘ вυɩɩϲҺίϲ𝗄е𝗇360
hi
is this a nootropic server? i joined from a random invite
@͘ вυɩɩϲҺίϲ𝗄е𝗇360
is this a nootropic server? i joined from a random invite
I said what I said. You acting like you know me for the past 10 years and have been studying beside me makes you look dumb and rude. Don't hmu until you change yourself again
half of those ideas prolly kill a lot of braincells
all the psych potentiation does
farily sure
chloitopia
yes
MEE6BOT
GG @chloitopia, you just advanced to level 12!
chloitopia
also: benzo potentiation
5thLeaf
however, i have proven noopept potentiates lsd 3x w my free mice
chloitopia
they tilted their heads at a 3 times higher angle
black humor is how slavs deal with emotional distress
5thLeaf
thats racist
should say dark humor
your just negging them at this point
if rapamycin wasnt hypertensive i prob would have snorted it all already
theres a 33% chance dihexa works great if i take today
66% it causes brainfog
1% chance i die
hmmmm
tis a thonker for certain
wheres my muse, i need inspiration
"Therapeutic sleep deprivation (SD) is a rapid acting treatment for major depressive disorder (MDD). Within hours, SD leads to a dramatic decrease in depressive symptoms in 50–60% of patients with MDD."
Find out where you can buy nootropics. Compare prices for all vendors worldwide. Filter by type: capsules, powder or solution. Sort products by price per gram, price per capsule or product price. Show listed products based on their content and weight.
Di you have better price?
5thLeaf
adrafinil is shit tho
even fladra is p shit
i havent tried armoda
but only moda is based for me so far
ibtisam.midlet
Do you have better price for any of them
Like dirty cheap
@5thLeaf
i havent tried armoda
veganpermanently
Armoda is the based part of racemic Moda. You can expect double potency
MC159 is a viral FLIP (FLICE inhibitory protein) encoded by the molluscum contagiosum virus (MCV) enabling MCV to evade antiviral immunity and to establish persistent infections in humans. Here, we show that MC159 contains a functional SH3 binding motif, ...
My "benign" viral infection
Your gonna tell me a virus is benign if it impairs ability for autophagy?
If I continue to have it it will almost certainly shorten lifespan
This is why rapamycin is the cure tho
5thLeaf
oh hey rapamycin fixes that
ibtisam.midlet
@everyone
This backup server invite
https://discord.gg/Ahx3kVsp69
Join it, It just backup users you can't read/write or get notified from it.
You sent an invite to join a server
animated
2 Online
8 Members
5thLeaf
i uhhhh, likely found a cure to an incurable virus
i just got lucky
the autophagy inhbition from molluscum is reveresed by rapamycin
BOOM
the science is in my server and the mouse is me lol
but also just fasting for a month should cure it
i admit the science is still weak
but theres enough connections for it to be a trialable hypothesis
if any researchers actually gave 2 shits
why do you think i dont own my own server
its a precaution
ibtisam.midlet
Stop misleading members
MEE6BOT
GG @ibtisam.midlet, you just advanced to level 12!
ibtisam.midlet
5thLeaf
uhm
i developed the ability to type eyes closed overnight
what the actual fuck
ibtisam.midlet
The attention deficit if was a human
take risperidone +_+
5thLeaf
you first
and take mine too babe
ibtisam.midlet
Doing x10 hard work to increase task quality from 95% to 99% will destroy your life
5thLeaf
I don't afaik
ibtisam.midlet
you might just addicted to baseline
dalta fos b can close your eyes
Happen to me
Just try things even if you thing they are useless
It will lead to a lot of discoveries
ibtisam.midlet
BTW @5thLeaf does modafinil halped you
What's the substances that can suck dick of coffee for you
5thLeaf
I hate baseline
I love moda
I hate amphetamine
ibtisam.midlet
Yeah amp induce psychosis
5thLeaf
Also just terrible for health
ibtisam.midlet
beta blocker and you eliminated the heart side effect of it
Tested before and works
Between you lost some rewards due to blockage of beta
5thLeaf
Yea yea but I'd rather profit off the amp
Theoretically
ibtisam.midlet
Cycling meds was not effective for me , I ended using 10 and everyone of them started to work once every month
Now I seek new receptors to fuck with
Found that a lot of emotions like optamistic is controled by widely unknown receptors
I'm reward travaler
@Sirsadalot do you have private emoji pack to rob
Controlling servers from a phone is awsome BTW!!
finally
5thLeaf
Oh I see, sirsad is here but not my server
raises fist
ibtisam.midlet
@abcd develop some plasticity from reading channels here, you would feel a stranger in first
@5thLeaf
Oh I see, sirsad is here but not my server
ibtisam.midlet
just act like its yours, in good way
5thLeaf
I'm taking piracetam rn @Sirsadalot
Btw, 44 g piracetam in 2 days is too much
Just a heads up
I always imagine suboxone delivery when I see subs-delivery
ibtisam.midlet
@abcd I invited you to sirsad server and other one, they are one of the best biohacking servers here
5thLeaf
Invite me too
To sirs
@5thLeaf
Btw, 44 g piracetam in 2 days is too much
ibtisam.midlet
When was the first time you took it
5thLeaf
4 years ago
1
@5thLeaf
Invite me too
ibtisam.midlet
Sirsad depandanat
Did he banned you
5thLeaf
No I lefted
A few weeks agos
ibtisam.midlet
I invited you to one
Wait
5thLeaf
Wronk one
But I'm upset w gintrux for not inviting me to that one
ibtisam.midlet
take lamotrigin to not feel such emotions
ibtisam.midlet
I have chemical solution for everything
@5thLeaf
i developed the ability to type eyes closed overnight
chloitopia
unimpressive tbh
learned this at 9 yrs old or so
however word count is hard to get up for me
@5thLeaf
But I'm upset w gintrux for not inviting me to that one
I did find a new way to get high but I can't disclose it because the community is a shithole stealing novel substances to make money. Whoever doesn't steal likes talking and it eventually ends up with Sirsad
Netizenne
:(
ibtisam.midlet
who care for being credited
Netizenne
yesegg
@chloitopia
I did find a new way to get high but I can't disclose it because the community is a shithole stealing novel substances to make money. Whoever doesn't steal likes talking and it eventually ends up with Sirsad
blank
Sell it yourself
fin
@veganpermanently are u mad hatterz?
Netizenne
They indeed are lool
@ibtisam.midlet
who care for being credited
chloitopia
it's nice to be credited but making money off of someone else's idea is straight Edison BS
@blank
Sell it yourself
chloitopia
Nootropic company from Croatia? you must be joking or don't know the situation here
1
@chloitopia
Click to see attachment
Netizenne
It was yanas find
Yana
@Netizenne
Yana
Yana
@komodo dragon 's
chloitopia
eggg
Yana
@chloitopia
Nootropic company from Croatia? you must be joking or don't know the situation here
blank
chloitopia
@komodo dragon
I have been told multiple times I look like Michael Jackson
I can't see the resemblance at all
was wondering why people make these funny connections
many times someone says someone looks like someone else but to me never
@chloitopia
Nootropic company from Croatia? you must be joking or don't know the situation here
blank
or maybe a partnership with an already established noot shop
@blank
or maybe a partnership with an already established noot shop
chloitopia
tried that with sirsa
went well
best solution is to move out of this beautiful hell
Cognitive enhancement is defined as the augmentation of the mind's core capabilities through the improvement of internal or external information processing systems. Recently, the focus has shifted to the potential therapeutic effects of natural products ...
The early stages of neurodevelopment in infants are crucial for establishing neural structures and synaptic connections that influence brain biochemistry well into adulthood. This postnatal period of rapid neural growth is of critical importance for cell ...
The rapid growth of infant brains places an exceptionally high demand on the supply of nutrients from the diet, particularly for preterm infants. Sialic acid (Sia) is an essential component of brain gangliosides and the polysialic acid (polySia) chains that modify neural cell adhesion molecules (NCA …
Buy Sialic Acid (N-Acetylneuraminic Acid) with a 30% stack discount from €20.55 /60 capsules. Next Valley supplies High Quality Sialic Acid with a Certificate of Analysis
I have steadily been increasing the dosage.
Started with just 600mg and worked my way up to 2 grams.
Breast milk has been shown to contain high levels of sialic acid and there's been studies evaluating how the time period of breastfeeding effects infant IQ.
chloitopia
did u notice anything
Potential
Keep in mind that I've only been using it for a couple of days.
But with that being said, I feel more alert for 2-3 hours after taking it and weirdly enough since taking it I have incorporated some small new things to my routine out of the blue. Pure optimization to already successful practises.
Also light brain tingles.
@chloitopia
@ibtisam.midlet what's your chemical solution for heartbreak
ibtisam.midlet
Anti empathy
@chloitopia
it's nice to be credited but making money off of someone else's idea is straight Edison BS
ibtisam.midlet
There was a time where getting money from work is like getting it from bank
You did not tested the power of biology
@ibtisam.midlet
Click to see attachment
Netizenne
Netizenne
Netizenne
Would getting good consistent cardio balance out the working memory deficits of cannabis use??????
@Netizenne
Would getting good consistent cardio balance out the working memory deficits of cannabis use??????
Potential
I don't think it would completely balance it but it would help.
I have personally fixed a guy's brain from years of cannabis abuse.
Improved his average grade by 2.
MEE6BOT
GG @Potential, you just advanced to level 3!
@Netizenne
Would getting good consistent cardio balance out the working memory deficits of cannabis use??????
veganpermanently
Not with concurrent use. If you stop consuming yes but you need to do as much as possible though you can do it at an easy pace. I recommend bike cycling because ligament and tendon injuries and insults are almost impossible to happen.
Also if you stop doing the exercise the deficits will quickly return. Benefits are best while exercising, which is why I recommend a stationary bike if you need it to do something on a computer. Otherwise normal bikes are better because of the mindfulness needed to pay attention to the road, this helps rebuild gray matter as well.
Netizenne
I gotta find an evolutionary tree of g coupled protein receptors evolution
Makes you feel like you don't even need to breathe anymore
fin
@veganpermanently thought about what you said and I no longer think intelligence is just as simple as g factor
1
@veganpermanently
I meant homesick heartbreak, it doesn't work for this. I'm low empathy since 2015 or so
ibtisam.midlet
when I'm very low in empathy (anafranil withdrawal) I don't have any type of it and completely empathy none responsive, but anyway blocking serotonin will harm you more then benefit you, it rarely act as depressant
dopamine 3 would greatly help
@fin
@veganpermanently thought about what you said and I no longer think intelligence is just as simple as g factor
veganpermanently
Glad u opened your mind
Netizenne
Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
Netizenne
An environment with excess resources becomes r-selected
Lots of feeding = lots of breeding perhaps
fin
The night before
@Netizenne
An environment with excess resources becomes r-selected Lots of feeding = lots of breeding perhaps
veganpermanently
But only if it is still space restricted. I.e. mouse Utopia experiment
ibtisam.midlet
@Netizenne why your account don't show up, I want to see you super mod x_x
fin
I found some old data showing a working memory test my psych professor administered to me. I thought I had found the perfect and most simplistic test. Yes it was only loosely correlated to Iq which probably isn't even the full picture
@ibtisam.midlet
@Netizenne why your account don't show up, I want to see you super mod x_x
Netizenne
?????
But I am!!!! D:
fin
I guess then I'll redefine my goal as general cognitive enhancement in any possible fashion I can muster.
@fin
I found some old data showing a working memory test my psych professor administered to me. I thought I had found the perfect and most simplistic test. Yes it was only loosely correlated to Iq which probably isn't even the full picture
veganpermanently
Little steps
fin
I don't think I see Iq as one pure thing anymore
@fin
I don't think I see Iq as one pure thing anymore
veganpermanently
Nice
@Netizenne
????? But I am!!!! D:
ibtisam.midlet
Netizenne
Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
Netizenne
I am going to worship this tree
I want to know it inside out
It will be my axis mundi -what holds it all together
@ibtisam.midlet
Click to see attachment
Netizenne
Owh rip
I am always invisible mode lol
@ibtisam.midlet
You did not tested the power of biology
chloitopia
no one did. I'm on the trajectory
fin
So I would probably aim to increase any of the following. When it comes to intelligence
- long term memory
- processing speed
- working memory
- implicit skill acquisition
- general brain health
- mental stamina
MEE6BOT
GG @fin, you just advanced to level 1!
@fin
So I would probably aim to increase any of the following. When it comes to intelligence - long term memory - processing speed - working memory - implicit skill acquisition - general brain health - mental stamina
chloitopia
discipline
fin
That too
Netizenne
Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
Netizenne
Holy crap those are also the sphingosine 1 phosphate receptors also crammed into that tiny branch along with MCR and endocanninoids!!!!! They’re all so closely related
Only thing I’m not familiar with on that branch is LPAR
@Netizenne
Holy crap those are also the sphingosine 1 phosphate receptors also crammed into that tiny branch along with MCR and endocanninoids!!!!! They’re all so closely related
fin
You are really into this
I wish I could join you
@fin
You are really into this
Netizenne
Treeeeeeeeeeesssss
@fin
So I would probably aim to increase any of the following. When it comes to intelligence - long term memory - processing speed - working memory - implicit skill acquisition - general brain health - mental stamina
ibtisam.midlet
Processing speed dopamine 1 , alpha 2 a adrenaline
Mental stamina =dfo IN
Netizenne
The treeeees connect it allll
Web of wyrd
fin
Maybe humans are just too evolved to get wm increases from dfo
Peptide hormones and growth factors bind to membrane receptors and regulate a myriad of processes in insects and other metazoans. The evolutionary relationships among characterized and un-characterized (“orphan”) receptors can provide insights into receptor-ligand biology and narrow target choices in deorphanization studies. However, the large n...
@fin
Apparently cb1 is related to variance in wm
chloitopia
in a perfect world we don't need cb1 agonism
but the world is very polluted
fin
Do you know anything about urb 597
chloitopia
so if you go live on a mountain at say 1-2000 m elevation you will be clearheaded all the time
Which I'm actually inclined to believe based on my experience with cannabis
Netizenne
Well it defiantly has been shown to decrease it after a while, so we atleast know it interacts with wm and that it has some role in the mechanisms of wm
@Netizenne
Well it defiantly has been shown to decrease it after a while, so we atleast know it interacts with wm and that it has some role in the mechanisms of wm
fin
What do you think about cb1s relation to anxiety and motivation
MEE6BOT
GG @fin, you just advanced to level 3!
@fin
Click to see attachment
chloitopia
I had same effects from high dose CBD
a bit less than a gram daily for a week
@fin
What do you think about cb1s relation to anxiety and motivation
Netizenne
Probably has some role modulating HPA axis
It’s related to MCRs and also has obvious effects on stress
Idk about motivation tho
chloitopia
made me not give a f about anything
very worrying state
fin
So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this.
The lack of vigilance could be more of a downside then its worth
@fin
What do you think about cb1s relation to anxiety and motivation
Netizenne
Working memory is essential for the organization of goal-directed behavior, as it maintains task-relevant information.
I wrote this earlier in response to that quote:
Working memory holds information to direct goals as well as the information to accomplish those goals?
It holds the check list and equation sheets to solve?
So say your working memory is divided into 7 slots to hold information.
If you have 5 goals instead of 1 does that limit how much free processing power you have to pursue those goals? (5 different classes in school)
People with adhd or autism who have a specific interest, I feel like that occupies too much space in their mind at all times for them to focus. Or maybe not.
MEE6BOT
GG @Netizenne, you just advanced to level 6!
@fin
So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth
blank
Work capacity > IQ anyways
@fin
So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth
chloitopia
indeed
it changes your personality
fin
Have you taken?
chloitopia
I am usually a very worried person. I take care that I and everybody around me are safe
fin
Hmm
@fin
@Netizenne thoughts?
Netizenne
I’ve never heard of Urb, looks interesting
chloitopia
but taking CBD completely removes this aspect of my personality
which is a detriment if you ask me
it would decrease intelligence by virtue of decreasing negative affect
fin
Hyper vigilance is probably correlated to IQ
This is difficult
chloitopia
indeed
if I could I would upregulate FAAH
fin
Really
@fin
Hyper vigilance is probably correlated to IQ
chloitopia
IQ is prerequisite to hypervigilance but hypervigilance is necessary to apply intelligence in everyday life
blank
What comes to mind when I think about vigilance is some 100 IQ go getter
@fin
So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth
Netizenne
CB1 agonism doesn’t acutely enhance wm does it?????????????
I’ve read that it can reduce it up to 3 months after cessation though.
@Netizenne
CB1 agonism doesn’t acutely enhance wm does it????????????? I’ve read that it can reduce it up to 3 months after cessation though.
fin
Nvm I misresd the paper u sent
It was
Gpr12
Netizenne
Check the one also linked directly above the one I posted
@Netizenne
Check the one also linked directly above the one I posted
The elucidation of Δ[9] -tetrahydrocannabinol as the active principal of Cannabis sativa in 1963 initiated a fruitful half-century of scientific discovery, culminating in the identification of the endocannabinoid signaling system, a previously ...
We discuss recent findings that corticotropin-releasing hormone in the amygdala enables hypothalamic-pituitary-adrenal axis activation via an increase in the catabolism of the endocannabinoid N-arachidonylethanolamine.
So the endogenous cannabinoid is constantly signalling to put the breaks on the HPA axis, and CRH activates it by increasing the breakdown of that endocannabinoid
In rodents, many exogenous cannabinoid agonists including Δ[9] -THC and WIN 55,212-2 (WIN-2) have been shown to impair short-term memory (STM) by inhibition of hippocampal neuronal assemblies. However, the mechanisms by which endocannabinoids ...
HPA axis controls stress and dealing with the problems causing our stress
elevated cortisol induced by stress increases serotonin uptake
1
(2a) Serotonergic mindset is problem solving mode
veganpermanently
Wut
Netizenne
Imo
veganpermanently
How does that follow
komodo dragon
Hey how are you all
veganpermanently
Can u link study about 5ht uptake
fin
This is madness
Netizenne
When I take psychedelics I feel like I can solve any problem, answer any question
I feel capable of any and everything on psychedelics, like I’m at 1000% functioning
@komodo dragon
Hey how are you all
veganpermanently
With a resting heart rate less than zero
Netizenne
When I take psychedelics I feel like I can solve any problem, answer any question I feel capable of any and everything on psychedelics, like I’m at 1000% functioning
Netizenne
Psychedelics made me feel like I was in problem solving mode
@Netizenne
When I take psychedelics I feel like I can solve any problem, answer any question I feel capable of any and everything on psychedelics, like I’m at 1000% functioning
fin
I don't know if you actually are able to
@veganpermanently
With a resting heart rate less than zero
komodo dragon
You've transcended us all
fin
Psychs are known to make people think they are smarter than they are and see patterns where there isn't any
I agree it increases pattern recognition
komodo dragon
Just wanted to put this out here: I think PRL could interact with GPR139
Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the ...
Stress and depression are characterized by elevation of circulating cortisol, as well as by changes in physiological functions. In this study, we addressed the possibility that elevated cortisol is also associated with the origin and development of depression. We report here that cortisol at the nM- …
Imagine if you couldn't passively cope and felt forced to actively engage every arrogant idiot who ever annoyed you to reduce how much their existence bothers you lol
…..I wouldn’t know xdddd
@Netizenne
Imagine if you couldn't passively cope and felt forced to actively engage every arrogant idiot who ever annoyed you to reduce how much their existence bothers you lol …..I wouldn’t know xdddd
Also idk if you’ve watched neon genesis evangelion -but I think how shinji accepts the situation his father puts him in (passive cope) and just fights the robots (active cope) it demonstrates a lot how the two systems can work together synergistically. They aren’t necessarily opposing i think.
fin
Meo seems mostly like 1a
Mabus Tiefsee
stupid question, how does the brain change when it goes from shugar metabolism to ketone metabolism.
Netizenne
HPA axis controls stress and dealing with the problems causing our stress
Netizenne
Does cannabis decrease serotonergic activity?
fin
I'm not gonna lie mice wm studies seem like shit
Not entering the same room twice is basically the extent of mice wm testing
Mabus Tiefsee
all behaviour mice/rat studis that include male researcher are scewed anyway. They react way more stressed around male smell. And as a rat breeder i can confirm that (and used that behaviour multiple times)
fin
I feel like that could include so much more than pure wn
Chimp studies would be a million times better since they can actually be taught wm games
u know Neti... 5HT1A has many problems. Nooking 5HT2A is one of them
chloitopia
they're opposing forces. life can either be easy, stuff gets put under the rug, or it can be hard, yet better by the day
second law of thermodynamics
whatever doesn't improve will get worse
so 5HT1A is an evil receptor
it is C.O.P.E.
/cancerous obedient people externalizing
We need to connect the TAFFA /thoughts actions feelings facts associations/ to gain the holy trinity of I /intuition intention intervention/, master the MAD /meaning aspiration dedication/ LAD /liberty alternation discipline/, defeat the DAD /distractions addictions delusions/ and finally, above all, complete the MISSION /mapping investigation structure superintendence infrastructure operation naturalization/.
NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological features. In the cell nuclei of the central nervous system, it is widely expressed and identified as a crucial regulator of dopaminergic (DA) neuronal differentiation, survival, and maintenance. Importantly, it ha …
Nr4a1 and Nr4a2 are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression ...
Dopaminergic neurons form in diverse areas of the vertebrate di- and mesencephalon to constitute several major neuromodulatory systems. While much is known about mammalian mesencephalic dopaminergic neuron development, little is known about the specification ...
NR4A2, a member of the nuclear receptor superfamily, is involved in modulation of target gene transcription, regulating several developmental processes such as regulation of cellular homeostasis, neuronal development, inflammation and carcinogenesis. 2q24.1 deletions are extremely rare, and only 1 p …
Attention deficit hyperactivity disorder (ADHD) is a highly heritable and common disorder thought to arise, in part, from alterations in dopamine function. NR4A2, or Nurr1, is an orphan nuclear receptor implicated in the development of dopaminergic cells of the ventral tegmental area (VTA) and the s …
Parkinson’s Disease (PD) is a neurodegenerative disorder affecting the motor system. It is primarily due to substantial loss of midbrain dopamine (mDA) neurons in the substantia nigra pars compacta and to decreased innervation to the striatum. ...
Parkinson’s disease (PD) is one of the most common neurodegenerative maladies with unforeseen complex pathologies. While this neurodegenerative disorder’s neuropathology is reasonably well known, its etiology remains a mystery, making ...
Nuclear receptors are of integral importance in carcinogenesis. Manipulation of classic ligand-activated nuclear receptors, such as estrogen receptor blockade in breast cancer, is an important established cancer therapy. Orphan nuclear receptors, such as nuclear family 4 subgroup A (NR4A) receptors, …
The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli, and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1) play an important role in maintaining cellular homeostasis and in pathophysiology. ...
wait i have something that will give u the attention span
@komodo dragon
wait i have something that will give u the attention span
chloitopia
it will come back in a few days
komodo dragon
itll make ur snake pent up.
chloitopia
I did this on purpose
komodo dragon
Overexpression of Nurr1 up-regulates Pitx3, TH and Vmat2 mRNAs
@komodo dragon
Overexpression of Nurr1 up-regulates Pitx3, TH and Vmat2 mRNAs
chloitopia
I know about Nurr1
MEE6BOT
GG @chloitopia, you just advanced to level 13!
komodo dragon
nr4a = nurr1
chloitopia
why you talking to me like I'm some noob
fin
These are the drugs I'm eye balling:
Ara 290 IN
Insulin
Clemastine
Phosphitidylserine
komodo dragon
D:
fin
Thoughts?
komodo dragon
seems good
i believe in u jukesta.
take clemastine close to bed though
chloitopia
Nurr1 is a good thing
do u have agonist?
Nook it roflmao
komodo dragon
chloroquine
@chloitopia
Nook it roflmao
komodo dragon
why
@komodo dragon
why
chloitopia
nookin has suddenly got a whole new meaning
Nurr1 agonist nooks it
fin
Ara 290 to unregulate epo
Insulin which probably has a myriad of benefits
Clemastine apparently myelinates the occular nerve
Phosphatidylserine for myelination
chloitopia
and antagonist stops the explosion
fin
Also rapamycin
@fin
Ara 290 to unregulate epo Insulin which probably has a myriad of benefits Clemastine apparently myelinates the occular nerve Phosphatidylserine for myelination
chloitopia
u putting it all in your eyes or wut
@chloitopia
and antagonist stops the explosion
komodo dragon
MEE6BOT
GG @komodo dragon, you just advanced to level 3!
fin
Which due to autophagy should help with synaptic pruning and de-noising my brain
@chloitopia
u putting it all in your eyes or wut
fin
I want better vision
@fin
I want better vision
chloitopia
did u try CDPC
fin
I think my brain is noisy right now from neurogenics
chloitopia
it improved my vision substantially
@chloitopia
did u try CDPC
fin
Nope havent
chloitopia
Tropoflavin as well
@fin
I think my brain is noisy right now from neurogenics
chloitopia
you've accumulated too much chloride
go ride a bike
for a few hours
you'll feel better
fin
Chloride?
From what?
chloitopia
also NMDA antagonist will help
@fin
From what?
chloitopia
from exogenously evoked BDNF
@chloitopia
go ride a bike
fin
Was just about to ride a bike actually
@chloitopia
from exogenously evoked BDNF
fin
Really
chloitopia
the neurons start piling chloride
exercise-induced BDNF gets rid of this chloride accumulation
it has differential effects
fin
When doing digit span I notice harder time reading and more noise than I used to
@chloitopia
also NMDA antagonist will help
judas
Other than NMDA antags is there anything else you can use
fin
Yea I've been wanting to exercise more
@judas
Other than NMDA antags is there anything else you can use
chloitopia
bromides but I don't recommend this you will fuck yourself permanently from it
fin
Exercise seems to be the most cognitively enhancing thing for me
@chloitopia
it has differential effects
Yana
wtf
@chloitopia
bromides but I don't recommend this you will fuck yourself permanently from it
fin
Thoughts on using rapamycin to de noise?
@Yana
wtf
chloitopia
I don't get surprised by these things anymore. Exercise uses every single mechanism in the best possible way
fin
I've been noticing an increase in autistic like symptoms
Noise and chaos agitates me more than it ever has
@fin
Thoughts on using rapamycin to de noise?
chloitopia
in my experience it only creates more noise
fin
Really
I thing autophagy would help cut down on loose synapses
chloitopia
yes. but fasting + rapamycin restarts the whole thing. neurogenics have effects similar to the honeymoon period for a while after the fast
rapamycin alone just creates a whole lot of confusion
pls remind me if I forget I'll review this in a few days
@fin
Restarts?
chloitopia
I just explained lol
it's like taking neurogenics for the first time
similar
fin
Oh
Wtf why
chloitopia
I guess it is effective at cutting the noise
but it does give me a headache
the day I take Rapa
I take it on day 3 of the fast
fin
Dose?
chloitopia
when AMPK is the highest
@fin
Dose?
chloitopia
4-6 mg oral
fin
Oh
chloitopia
capsulated
fin
I assumed you would use IN
chloitopia
no
I'm not Pax
and I don't advocate that
fin
Isn't oral rapa more systemic?
chloitopia
it's just a meme
fin
In rapa?
@fin
Isn't oral rapa more systemic?
chloitopia
yes
fin
I know that drugs taken IN target the brain better
chloitopia
but it is unknown what is the difference
fin
For the most part
@chloitopia
but it is unknown what is the difference
fin
What's your opinion on pax
@fin
What's your opinion on pax
chloitopia
I have not talked to him for a long time
fin
Like it's true that he can be sporadic but he did what pretty much everyone in the nootropic community does
chloitopia
last time I heard from him he sent me a voice recording yelling at me for 2 mins straight
1
fin
He did his research he found some things that hypothetically would increase cognition
And yet those things did not increase cognition
Namely dfo
By all means dfo should have worked
It had lots of promise
Yet it didn't live up to the hype
Mabus Tiefsee
the main problem with brain abilitys, the amount you can increase is limited. You can't turn an idiot into a genious (maybe transhumanists can do that sometime with brainimplants combined with AI)
same with lifespan. You may be able to get 10-50 extra years, but that's it
@fin
He did his research he found some things that hypothetically would increase cognition
chloitopia
He tries to find fringe substances no one else used and use them to increase cognition according to his holistic understanding of the brain
This is similar to my approach, except I don't use substances that may cripple me in some way
1
fin
True but you have to admit dfo had alot of research
chloitopia
First and foremost I look for substances that already have human or at least animal research behind them
@chloitopia
This is similar to my approach, except I don't use substances that may cripple me in some way
Mabus Tiefsee
no risk no fun, i use carcinogenes
@Mabus Tiefsee
no risk no fun, i use carcinogenes
chloitopia
this is a very irresponsible thing to say in this space
@Mabus Tiefsee
no risk no fun, i use carcinogenes
fin
Lol
Mabus Tiefsee
should i lie about the carcinogen abillity of igf1 and vit b3? it's a tradeoff
chloitopia
I am like a golden mean of Sirsad and Pax, one of them has no holistic understanding, while the other applies no risk management
2
Yana
b3 lol how
@Mabus Tiefsee
should i lie about the carcinogen abillity of igf1 and vit b3? it's a tradeoff
chloitopia
that's not what I meant
'no risk no fun'
Mabus Tiefsee
ah yeah, that part
Yana
Inhibiting FAO and SIRT is anti cancer
chloitopia
we need to strive to prevent risk at every cost
because that will make us go further
Mabus Tiefsee
sirt reminds me, i should eat some of my shugar limited wild cherrys again... taste good and healtgy
@Mabus Tiefsee
sirt reminds me, i should eat some of my shugar limited wild cherrys again... taste good and healtgy
my mindset is different, wevhave to educate on tge tradeoffs; you wabt biger musckes and a longer dong? No problem HOWEVER your cancer risk will increase and you will suffer the following list of symptoms (insert agromegaly description)
@Mabus Tiefsee
my mindset is different, wevhave to educate on tge tradeoffs; you wabt biger musckes and a longer dong? No problem HOWEVER your cancer risk will increase and you will suffer the following list of symptoms (insert agromegaly description)
chloitopia
I have ways to grow muscle without cancer risk
@chloitopia
dude where r u
Mabus Tiefsee
made jam without shugar, the substances won't be destroyed if not heated above 120 (or something like that)
chloitopia
u know
Mabus Tiefsee
tried that, got to low natural backgroubd igf1 in my body
chloitopia
if you find me a piece of evidence showing exercise causes cancer I'll give up everything to your approach
yet it increases IGF1
yet it grows muscle
but this is just an example
so many interventions that grow muscle yet decrease cancer risk
Mabus Tiefsee
exercuse does not cause cancer but it is low, tidious and bot everybody can get the same results based on their genetics
chloitopia
time and tissue selectivity of interventions is key
Mabus Tiefsee
and to see the cancer risk, i give my 17 year old cat calf liver, she loves it, it prevents muscledystrophy and i will see how big the cancer risk is truly.
@Mabus Tiefsee
exercuse does not cause cancer but it is low, tidious and bot everybody can get the same results based on their genetics
chloitopia
I don't mind the work
I have time because of the antiaging interventions
I have willpower because of the cognitive enhancement
so why not
Mabus Tiefsee
it all started because i wabted to grow my cheekbones/chin. That failed/was to slow however the musclegrowth is excelent. GH gut was a problem because of training problems
Yana
Liver fr gave you acormegaly and GH gut?
@Yana
Liver fr gave you acormegaly and GH gut?
chloitopia
plot twist: the BCAA excess gave him visceral fat
Mabus Tiefsee
acromegaly simptoms. And the GH gut just started to apear once i trained my abs. It disapeared when i trained the inner abs (vaccum is the training method that helps)
@Mabus Tiefsee
acromegaly simptoms. And the GH gut just started to apear once i trained my abs. It disapeared when i trained the inner abs (vaccum is the training method that helps)
and attribute it to an unknown force we'll look for later
@Yana
BCAA doesn't make your hands grow from M to XL
Mabus Tiefsee
just temporary XL for a month. Before that easy to wear M gloves. After they shrunk back (little swollen) tgey where barely L but the gloves didn't break anymore therefore L
@Mabus Tiefsee
just temporary XL for a month. Before that easy to wear M gloves. After they shrunk back (little swollen) tgey where barely L but the gloves didn't break anymore therefore L
chloitopia
bone growth cannot revert
what you had was water retention from the inflammation
@chloitopia
bone growth cannot revert
Mabus Tiefsee
XL was partyally because the tissue grew/swollen (happend in my face as well) and the bonegrowth was slower than the tissue growth. And yes, not reversable. Still size L hands.
And i assume if i had more calcium in my diet, the bones could have grown further. But that's just an asumption
Before that i fit easily in site M gloves. Now i fit barely in size L and rip apart size M gloves
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Mabus Tiefsee
oh by the way i was on a strict carnivore diet during that time. Therefore the glucose intake was one bar of chokolate a week or nothing.
Mabus Tiefsee
no matter what it was, it was direktly after eating 2,5 kg raw calf liver. And the symptoms matched IGF1 overexpression sideeffects.
@chloitopia
I am like a golden mean of Sirsad and Pax, one of them has no holistic understanding, while the other applies no risk management
ibtisam.midlet
Combine considerable impulsivity and smartness with curiosity and you will solve everything
5thLeaf
You just described me
1
@ibtisam.midlet
Combine considerable impulsivity and smartness with curiosity and you will solve everything
Potential
I lack the impulsivity.
Every move I make and the next 5 after that are meticulously calculated.
This has brought me great success in life but has also hindered me in other ways.
@Potential
I lack the impulsivity. Every move I make and the next 5 after that are meticulously calculated. This has brought me great success in life but has also hindered me in other ways.
Mabus Tiefsee
i was like that once, too. With age comes the attitude "just du stuff and see what happens"
I've used a dirty Nurr1 agonist that paradoxically reduced dopamine availability
it was hell
zero motivation until it was completely gone from my organism. recovered with modafinil
if u know a selective agonist let's go
Mabus Tiefsee
what gives me motivation to do stuff, but i don't want to do it. Removing my smartphone. I assume it is way to efficient in removing bordom for my own good...
@Mabus Tiefsee
what gives me motivation to do stuff, but i don't want to do it. Removing my smartphone. I assume it is way to efficient in removing bordom for my own good...
chloitopia
tried that
with an antipsychotic removing stimuli will not help
Mabus Tiefsee
i assume at this point, your brain became an abnormallity anyway (if you where born with a normal one?) and therefore everything has to be discovered for your specific one anyway
@Mabus Tiefsee
i assume at this point, your brain became an abnormallity anyway (if you where born with a normal one?) and therefore everything has to be discovered for your specific one anyway
chloitopia
one more person not to talk to ig
@fin
Dose?
Netizenne
They made a long detailed post a while back in this channel you should look for
The transcription factor Nurr1 has been identified to be ectopically induced in the striatum of rodents expressing l-DOPA-induced dyskinesia (LID). In the present study, we sought to characterize Nurr1 as a causative factor in LID expression. We used rAAV2/5 to overexpress Nurr1 or GFP in the parkinsonian striatum of LID-resistant Lewis or LID-p...
@chloitopia
in my experience using 10 g leucine and 4 g lysine for 2-3 weeks produced insulin resistance and gave me visceral fat which was hard to get rid of
Mabus Tiefsee
next time you want to lose fat in specific areas, increase the bloodflow there while you are hungry/in energy defency. The ways for increasing the bloodflow are using muscles in that area/massage/hitting that area with a flat hand/vibration/chilly cream
With increased blood flow, the fat cells get priority to be used
Message could not be loaded.
Netizenne
Wait I actually didn’t understand what I was saying when I posted this.
I thought cortisol raised serotonin lmaoo
Whoops, embarrassing :/
I guess it still kinda makes sense tho lol
@Potential
I lack the impulsivity. Every move I make and the next 5 after that are meticulously calculated. This has brought me great success in life but has also hindered me in other ways.
ibtisam.midlet
Impulsivity is more benfitical then harm
I found my self go to work in things without caring much about the stress Ill get evuantulay due to responsapility a started to work 24h a day which solved my unproductivity.
@chloitopia
I've used a dirty Nurr1 agonist that paradoxically reduced dopamine availability
komodo dragon
whatd u use
fin
Time to give up on increasing IQ and figure out how to turn people into anime girls
1
@komodo dragon
whatd u use
veganpermanently
Doxycycline
@ibtisam.midlet
Impulsivity is more benfitical then harm
veganpermanently
Mindfulness makes impulsivity safe. Mindless impulsivity will killya
1
@fin
Time to give up on increasing IQ and figure out how to turn people into anime girls
Pax1l
Simp
1
fin
Nah it's domination
Turn ur homies into anime girls and make a harem
veganpermanently
Someone has been watching Andrew Tate
@chloitopia
I did not have visceral since I was 14 yrs old so that was out of ordinary
Netizenne
I had no visceral till like a few months ago
it’s not much but now I’m spooked
I have to start exercising to stay in shape
it’s cause I’m 21 in a few days
veganpermanently
Do my FMD protocol
Netizenne
Reading about how fat cells never get removed once you’ve grown new ones was really spook
Like once you fuck up and eat too much once, those fat cells are with you for life, and the only way to keep them from filling up from that point on is to exercise
Ngl I’ve gotten away with eating pretty unhealthy and never exercising up until this point with no issue
@Netizenne
Reading about how fat cells never get removed once you’ve grown new ones was really spook Like once you fuck up and eat too much once, those fat cells are with you for life, and the only way to keep them from filling up from that point on is to exercise
Alyen
What? As in old fat is only burned after new fat is burned?
MEE6BOT
GG @Alyen, you just advanced to level 1!
@Alyen
What? As in old fat is only burned after new fat is burned?
Netizenne
When you lose weight your emptying fat cells of lipids.
When you gain weight your filling them with lipids.
And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them.
@Netizenne
When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them.
veganpermanently
Fat cells can get huge, some researchers even think people have a fixed number of fat cells
chloitopia
@Netizenne visceral fat cells are the ones that get huge and this implicates the insulin resistance, inflammation and so forth. We can gain fat cells but those are the cool subQ ones.
I want to keep as much subQ fat as possible while still maintaining zero visceral fat. exposing subQ fat to cold turns it to something similar to brown fat or what I like to call metabolic fat.
@Netizenne
When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them.
Alyen
Am I retarded or can you not just lose weight to get rid of the fat cells
chloitopia
This kind of fat produces heat when stimulated by either cold or heat AND 5ht2a agonism
so it's fat that actually burns calories and keeps you insulin sensitive. Kind of like muscle
Alyen
Is that “brown fat”
@Alyen
Is that “brown fat”
chloitopia
no, it's white fat that has turned brown
it's not the same tissue but it has the same effects
@chloitopia
no, it's white fat that has turned brown
Alyen
So it is brown fat?
chloitopia
I keep forgetting I block people for a reason
@Netizenne
When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them.
ibtisam.midlet
Adipocyte size 0.1mm empty , 0.3mm full
we are fucked
@chloitopia
I keep forgetting I block people for a reason
Alyen
ibtisam.midlet
Adipocyte size 0.1mm empty , 0.3mm full we are fucked
Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. In cell culture, adipocyte progenitors can also form osteoblasts, myocytes and other cell types.
Ther...
American Physiological Society
Netizenne
Butterflies are outt
@Netizenne
Butterflies are outt
chloitopia
hhmmm
I have trouble IDing Rosa species
rugosa came to mind when I saw that
Netizenne
chloitopia
it must be rugosa
take it
it is nootropic
not the butterfly but the plant
ibtisam.midlet
Did anyone mega dosed rediola
@chloitopia
not the butterfly but the plant
Netizenne
@ibtisam.midlet
Did anyone mega dosed rediola
judas
I’m curious as to what this would do
Netizenne
I could never!!!!
looooool
Those butterflies don’t grow in factories y’know
chloitopia
my ex and I had a love triangle with a butterfly
1
he was magnificent
we fed the caterpillar and it turned into a butterfly
1
and he didn't want to leave my ex
for 2 week
I was jelly
Netizenne
Pretty bugs
MEE6BOT
GG @Netizenne, you just advanced to level 7!
@judas
I’m curious as to what this would do
ibtisam.midlet
Excepted to be less side effect in dose to dose potency of wallbutrine
Netizenne
There’s alotta grasshoppers flying around lately
They kinda remind me of tiny winged reptiles lmfao
@Netizenne
There’s alotta grasshoppers flying around lately They kinda remind me of tiny winged reptiles lmfao
Citrate is an essential substrate for energy metabolism that plays critical roles in regulating cell growth and survival. However, the action of citrate in regulating metabolism, cognition, and aging at the organismal level remains poorly understood. Here, we report that dietary supplementation with …
1
yooooo
you know where this goes
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity
Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap.
3
2
@komodo dragon motherfucker
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity
Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap.
komodo dragon
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity
Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap.
Disruption of neuronal iron homeostasis and oxidative stress are related to the pathogenesis of Parkinson’s disease (PD). Alpha-lipoic acid (ALA), a naturally occurring enzyme cofactor with antioxidant and iron chelator properties, has many known effects. It is known that ALA has neuroprotective effects on PD, but its underlying mechanism remain...
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity
Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap.
@fin
will use citrate as filler now for everything
it's fucking ridiculous
fin
Que
@fin
Que
chloitopia
do you even citratize yourself
fin
Nah scurvy-maxxing
@fin
Nah scurvy-maxxing
chloitopia
missing out
I'm gonna start dosing it constantly
hmmm
maybe citrate tablets in shape of lemon
fin
Effects?
chloitopia
yeheheheheee
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity
Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap.
Limunska kiselina,
na usta ide mi slina,
ja volim taj spoj,
ja sam mašina,
ja sam stroj.
chloitopia
@Yana
it's ridiculous
Yana
@Yana
chloitopia
kek
there must be some errors with that metric
it's impossible to maintain the ratio they suggest
Yana
Going gorilla on the leafy greens is the only way without supplements
@Yana
Going gorilla on the leafy greens is the only way without supplements
chloitopia
I see no point
people eat vegan food, lift weights and have the same bone density
To detect citrate levels in fresh tomato juice, to reveal whether it can be studied for prevention of recurrent hypocitraturic nephrolithiasis.Juices …
Scientists are experimenting with larva fat to replace butter. They soak insects in water and then mush them with a blender before centrifuges separate a butter-like substance, which the team then uses to bake with https://t.co/dIkTtYWV68
Likes
2397
Retweets
1048
Twitter•02/29/2020
@chloitopia
exercise-induced BDNF gets rid of this chloride accumulation
Netizenne
Do you have any studies on that? Know why that might be?
Maybe it’s partly reliant on mechanical filtration the way the lymphatic system is??? Or else is there probably another pathway out there we could theoretically hack??
Netizenne
Does anyone know a good source for pregnenolone nasal sprays?
Do you have any studies on that? Know why that might be? Maybe it’s partly reliant on mechanical filtration the way the lymphatic system is??? Or else is there probably another pathway out there we could theoretically hack??
veganpermanently
Nah transporters become regulated. Exercise is mainly an epigenetic intervention. This is why we don't have drugs that mimic exercise fully. It's effects are too complex but also we only have a few thorough screenings for epigenetic effects of small molecules.
this hair growth effect and the accompanying feminization and erectile dysfunction is likely due to the inhibition of 5 alpha reductase.
MEE6BOT
GG @chloitopia, you just advanced to level 14!
chloitopia
the hair growth is also likely to be promoted by it's antiinflammatory properties.
it is also an aromatase inhibitor which would make one think it would stop gynecomastia, but the net effect is negative because DHT is a powerful inhibitory factor in the breast tissue and even without estrogen, with enough prolactin and IGF1 the tissue can grow.
all in all it's a very dirty drug if we're looking at it from this perspective. the negative effects can even be pronounced with topical use.
ibtisam.midlet
interesting
MEE6BOT
GG @ibtisam.midlet, you just advanced to level 13!
Alyen
brehhhh homie got fucked up
ibtisam.midlet
What heppen
@ibtisam.midlet
What heppen
Alyen
I was referring to the guy getting gyno and ED from nettle extract
I did fall off my skateboard recently and my back hurts rn tho :/
1
@Alyen
I was referring to the guy getting gyno and ED from nettle extract
A lower incidence of dementia in bipolar patients treated with lithium has been described. This metal inhibits the phosphorylation of glycogen-synthase-kinase 3-α and β, which are related to amyloid precursor protein processing and tau hyperphosphorylation in pathological conditions, respectively. F …
The noradrenergic locus coeruleus is a major wakefulness-promoting nucleus of the brain, which is also involved in the regulation of autonomic and endocrine functions. The activity of the locus coeruleus is believed to be tonically enhanced by a mesocoerulear dopaminergic pathway arising from the ve …
@chloitopia
@Netizenne I'm making a breakcore mix motherfucker
Potential
Link it when it's done.
@Potential
Link it when it's done.
chloitopia
in a few mo roflmao
@chloitopia
in a few mo roflmao
Potential
Exactly.
I will remember.
chloitopia
I'm cheap I don't wanna buy a turntable so I just wait for my friend to let me play at his house
@chloitopia
I'm cheap I don't wanna buy a turntable so I just wait for my friend to let me play at his house
Potential
Maybe try it first at your friend's house.
Or borrow it for an undefined amount of time if he's not using it.
chloitopia
turntable is the last on my list lel
nah he's using it
1
that's why I must wait
already played a few times
it's fun as hell
Potential
Playing at a party as a DJ is on my bucket list.
chloitopia
it's so cool
when you see drugged out people drooling over the speakers
@chloitopia
when you see drugged out people drooling over the speakers
Potential
Utopia.
@Potential
Utopia.
chloitopia
and you're all clear headed nooted up ready to strike the mofo who breaks the equipment
then you shut off bass and echo and reverb over only the high
motherfuckers transcend
sadly they don't remember it day after
@chloitopia
Armoda downregulates prolactin and nightly GH release
Yana
Oh dayum are there actual differences like this between moda and armoda beyond half life or is that just what you were taking
@Yana
Oh dayum are there actual differences like this between moda and armoda beyond half life or is that just what you were taking
chloitopia
armoda is the active part of modafinil
I'm not sure esmoda does anything worthwhile
Yana
So is S-moda no?
I thought S-moda is just modafinl with like 6 hour half life. But no clinical efficacy or something
chloitopia
@komodo dragon I forgot to tell you I don't hate all peptides. I love dipeptides. They're all orally active, never heard of antibodies to them, they are usually very stable compounds, they're easy and cheap to produce.
they can also be grafted to various small molecules to yield extra activities, reduce sides, improve potency, pharmacokinetics, etc.
@chloitopia
@komodo dragon I forgot to tell you I don't hate all peptides. I love dipeptides. They're all orally active, never heard of antibodies to them, they are usually very stable compounds, they're easy and cheap to produce.
komodo dragon
not all peptides are created equal
@komodo dragon
not all peptides are created equal
chloitopia
indeed, but the rule of thumb goes, the bigger the worse
1
@chloitopia
@Netizenne I'm making a breakcore mix motherfucker
Netizenne
I wish you good luck, break core soothes the soul!!!!!!!!!!!
Sphingosine-1-phosphate (Sph-1-P) regulates critical cellular functions including cell proliferation, differentiation, angiogenesis, and cell survival. However, its mechanisms of action are incompletely understood. Here, we show a novel biological effect of Sph-1-P: inhibition of acidic sphingomyeli …
komodo dragon
@veganpermanently@chloitopia@Potential pray for haiti is such a good album man
The Olmec tribes created images of a toad god of rebirth, eating its own skin. It is reborn by consuming itself, caught in a cycle of death and rebirth, like people, and like the natural world itself. @Netizenne
It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonist …
Home BLOW YOUR MIND WITH SCIENCE
Original message was deleted.
chloitopia
autoxidation
MAO B is endogenous
why would the body produce a protein that makes damage to the body
it makes no sense
MAO B is protective against VMAT2 dysfunction
you don't have understanding of this sry I'm not here to argue
Original message was deleted.
chloitopia
study release dynamics
you will understand that vesicular release is 100% necessary to keep oxidative load restrained
Original message was deleted.
chloitopia
actually I prefer to call those substances reuptake transporter agonists
they don't inhibit the transporter, they reverse it
like cocaine, methylphenidate, amphetamine
modafinil is a true reuptake inhibitor
Original message was deleted.
chloitopia
again, your understanding is brief
you don't have a clue about transporter conformations
I can teach but you seem stubborn, set in your ways
MEE6BOT
GG @abcd, you just advanced to level 3!
chloitopia
mkay
so the transporters can have 3 states
one is uptake, that's normal, it pulls monoamines to the neuron cytosol from the presynaptic cleft and from cytosol to vesicules
another is inhibition, it's when the transporter does not work anymore
and the third state is called open-to-out conformation, it's when the transporter leaks contents in the opposite direction of normal
the third state is what methylphenidate, cocaine and amphetamine produce
mph and cocaine do not touch VMAT2
but amphetamine produces open-to-out conformation for VMAT2 too
this creates a brain state that's independent of cellular energy, it does not matter if mitochondria produce ATP or not, if you eat enough, if you're healthy or sick
you don't have a clue about transporter conformations
fin
So citric acid is based?
1
ibtisam.midlet
Fuck Thailand ahhh
Why you deleted the message
fin
Dw about it
1
Alyen
What type of stf
MEE6BOT
@Alyen, you just advanced to level 2 respect++
Alyen
Std
fin
Cab I get citric acid from lemon juice?
Alyen
Nooo
@fin
Cab I get citric acid from lemon juice?
ibtisam.midlet
they use it to convert some drugs, so yes
Addictio cause you to be smart
fin
Idk how much
I'll just wing it
Taking creatine and lemon juice
@fin
Cab I get citric acid from lemon juice?
((odder_sea (glow-worm))
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity
Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap.
Plasticity receptors seems to have other functions then this , which I don't know shit about
Anyone know more feel free to give input
@fin
So citric acid is based?
The Blur
Manufactured citric acid no wtf. Who gave u that idea?
fin
Resolution thought
chloitopia
I prefer to improve my life before I improve my mind
Alyen
@The Blur
Manufactured citric acid no wtf. Who gave u that idea?
((odder_sea (glow-worm))
VP
@fin
Resolution thought
The Blur
?
@((odder_sea (glow-worm))
VP
The Blur
Who is VP
@The Blur
Who is VP
((odder_sea (glow-worm))
@veganpermanently
The Blur
Oh
Just to clarify MCA should be avoided. Citric acid derived from food is fine (there is no supplement for this)
@The Blur
?
fin
Neuron spike model of working memory
@The Blur
Just to clarify MCA should be avoided. Citric acid derived from food is fine (there is no supplement for this)
((odder_sea (glow-worm))
What's the rationale for avoiding manufactured citric acid?
fin
It's not just number of items. It's one item and the resolution that that item is represented at
Alyen
Yeah what exactly makes mca bad but citric acid ok
@Alyen
Yeah what exactly makes mca bad but citric acid ok
((odder_sea (glow-worm))
Sometimes synthesized versions of molecules have no beneficial, or even paradoxical effects compared to natural source. Astaxanthin is an example of this
fin
Like a TV is a device which is 1st order of abstraction. Then the TV is the TV. Then specific details like the show playing, the model, the color. Then hyper specific details like the button placement and the writing.
This is how working memory works. It's not just a few items
@((odder_sea (glow-worm))
What's the rationale for avoiding manufactured citric acid?
The Blur
Approximately 99% of the world production of MCA is through microbial processes using toxic black mold Aspergillus niger [1].
Citric acid naturally exists in fruits and vegetables. However, it is not the naturally occurring citric acid, but the manufactured citric acid (MCA) that is used extensively as a food and beverage additive. Approximately 99% of the world’s production ...
fin
Each level down you have exponentially more things to remember since its higher resolution
@((odder_sea (glow-worm))
Sometimes synthesized versions of molecules have no beneficial, or even paradoxical effects compared to natural source. Astaxanthin is an example of this
Alyen
I dont think thats the case with citric acid
fin
High IQ individuals might seem to have low WM sometimes but that's just with one resolution
The Blur
MCA comes from black mold. It’s too expensive for companies to derive it naturally from food
Alyen
Lmfaoooo what
Nigga thinks they are making citric acid out if black mold
@Alyen
Nigga thinks they are making citric acid out if black mold
Citric acid naturally exists in fruits and vegetables. However, it is not the naturally occurring citric acid, but the manufactured citric acid (MCA) that is used extensively as a food and beverage additive. Approximately 99% of the world’s production ...
Alyen
Apergillus niger and candida is not black mold
The Blur
Lmfao
Alyen
Those are native bacteria in your stomach
The Blur
This guy doesn’t know that aspergillus niger IS black mold
((odder_sea (glow-worm))
This is four case reports, and the only postulated mechanism is black mold pathogens, which I assume is able to be purified out.
Also, IIRC, Aspergilus Niger isn't the "black mold" that tends to cause severe respiratory/CFS diseases, but it's cousin, aspergailus Fumigatus.
I'm sure that aspergilus could cause issues in people who have an allergy, But IIRC it's mostly a threat in its live form, when it tries to colonize the lungs
Alyen
Yeah im retarded..I got it mixed up with the aspergillus you ferment miso with
@The Blur
This guy doesn’t know that aspergillus niger IS black mold
((odder_sea (glow-worm))
It's one of the big three, but IIRC by far the least toxic, mostly a threat due to infection of airways
Alyen
Still the theory is what, that toxins are somehow staying in the citric acid?
((odder_sea (glow-worm))
It's the one that frequently grows on fruits and in onions
@Alyen
Still the theory is what, that toxins are somehow staying in the citric acid?
((odder_sea (glow-worm))
I suspect it is an allergic response from people that are allergic to the mold
I have CFS from living in a house that wound up being condemned due to Starchybortris contamination, had pneumonia off and on for a year
So I could possibly be in that camp, but since it's a different strain of fungi, I doubt it
@((odder_sea (glow-worm))
I suspect it is an allergic response from people that are allergic to the mold
Alyen
Isnt that the same thing, you are saying something in the mold is staying in the citric acid even after purification
@Alyen
Isnt that the same thing, you are saying something in the mold is staying in the citric acid even after purification
((odder_sea (glow-worm))
That was my takeaway from reading the article, also the only plausible mechanism I can think of
But I'm sure you can get as much or more Aspergillis, in whole form, just from eating produce
Including fresh lemons
Alyen
Yeah thats interesting
Its always worrying when the fact checkers tell you not to worry about something
@Alyen
Yeah im retarded..I got it mixed up with the aspergillus you ferment miso with
blank
Alyen
Fuck you blank
MEE6BOT
@Alyen, you just advanced to level 3 respect++
@((odder_sea (glow-worm))
It's the one that frequently grows on fruits and in onions
It's a pure substance who cares where it comes from roflmao. You won't get mold poisoning with citric acid. However they may be other treaths using high doses. I am investigating
It is an approved food additive so you can use small doses with no worry
@Yana
like in my medjool dates?
veganpermanently
The faint white coating you can observe on the skin of sweet fruits is a strain of yeast similar to Baker's and Brewer's yeast, S. cerevisiae
Harmless
Every other color on food means it has gone bad potentially deadly. If it's thick white it can still be mold but hasn't sporulated yet. Throw
@Alyen
Its always worrying when the fact checkers tell you not to worry about something
When an agonist bind to receptor complex its agonist its receptor, but prevent the other receptor from getting agonisted without providing any agonist efficacy in replacement
@veganpermanently
It's a pure substance who cares where it comes from roflmao. You won't get mold poisoning with citric acid. However they may be other treaths using high doses. I am investigating
((odder_sea (glow-worm))
Uncompensated metabolic acidosis?
@veganpermanently
The faint white coating you can observe on the skin of sweet fruits is a strain of yeast similar to Baker's and Brewer's yeast, S. cerevisiae
((odder_sea (glow-worm))
Aspergillis often grows on the inside of dates, between the fruit and the pit. Nicknamed the black pit, absolutely gross, but I'm sure there's plenty in small amounts on lots of dates, that I don't notice.
This is the same kind that grows between the paper/layers of onions.
It doesn't produce substantial amounts of aflatoxin, like its cousin aspergillis fumigatus, I don't consider it to be a huge health hazard by any stretch when consumed in tiny quantities in food for most people.
1
I'm earing Muscadine grapes from a friend's orchard right now. I'm sure some of these have aspergilis growing in/on them.
I think peanuts often get contaminated with aflatoxin, though, possibly through fumigatus, or another strain
BTW
Muscadine grapes?
One of the healthiest things in existence, buddy. Its like the American AMLA berry
What is the primary endogenous super agonist I wonder?
@Netizenne
What is the primary endogenous super agonist I wonder?
veganpermanently
Bofutenine
5 Meo as well
Serotonin itself could probably be psychedelic in specific brain states
Netizenne
DMT possibly???
@Netizenne
DMT possibly???
veganpermanently
Prolly but it is weaker compared to what I mentioned
1
@veganpermanently
Serotonin itself could probably be psychedelic in specific brain states
Netizenne
It’s no superagonist tho!
@Netizenne
It’s no superagonist tho!
veganpermanently
The comformation of the heteromer can change
2
Netizenne
Owhhh so many factors
What’s are the most common natural situations in which 5HT2a and mGluR2 interact, what is the natural function of their relationship????
Can only wonder
@veganpermanently
The comformation of the heteromer can change
Netizenne
Altered topography
@Netizenne
What is the primary endogenous super agonist I wonder?
ibtisam.midlet
DMT but trigger just when you die
@Netizenne
DMT possibly???
ibtisam.midlet
Yeah
@ibtisam.midlet
DMT but trigger just when you die
veganpermanently
Nah I'm pretty sure schizoautist spectrum people release it on the daily
2
ibtisam.midlet
We need someone on benzo here
2
blank
@ibtisam.midlet why did you steal Swiss chads PFP this is so confusing
2
ibtisam.midlet
veganpermanently
Make her look to the right so we can tell you apart
Horizontal flip
1
@veganpermanently
It is an approved food additive so you can use small doses with no worry
The Blur
Lmfao the term approved means nothing
Keep clinging to your FDA approved nonsense. You will definitely outlive us all
@veganpermanently
It's a pure substance who cares where it comes from roflmao. You won't get mold poisoning with citric acid. However they may be other treaths using high doses. I am investigating
The Blur
Blocked for spreading your false information and endangering people
MEE6BOT
@The Blur, you just advanced to level 3 respect++
ibtisam.midlet
Majority always label minority opinion as pseudoscience
@ibtisam.midlet
Majority always label minority opinion as pseudoscience
veganpermanently
The prob is he tried to substantiate his statement saying citrate is not healthy because it's produced by Aspergillus sp. This is nonsense. Now he's saying I'm endangering ppl saying they can consume something everyone consumes anyways. Obv if u were to capsulate pure citric acid it would cause irritation but dude use common sense and do look it up. It's safe to add to water at least 5 g/L if not more
ibtisam.midlet
It was just thought
@ibtisam.midlet
Majority always label minority opinion as pseudoscience
Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolysed by specific glycosidases, some also catalyzing synthetic transglycosylation reactions. The documented value of plant-derived glycoconjugates to beneficially modulate metabolism is first addressed. Next, focus is given to glycosidases, the...
>SAGE
why does alcohol cure my depression @ibtisam.midlet
@>SAGE
why does alcohol cure my depression @ibtisam.midlet
Potential
Alcohol being a weak Gaba A agonist probably helps.
@>SAGE
why does alcohol cure my depression @ibtisam.midlet
ibtisam.midlet
Seems Your depression is anxiety based
@ibtisam.midlet
Seems Your depression is anxiety based
>SAGE
most likely so id say
@>SAGE
most likely so id say
ibtisam.midlet
There alcohol acculvent you might cycle them
Prazepam( slowest benzo in tolerance)
Pregabaline (calsium channel antagonist)
Etifoxin (gaba a-rho agonis)
@ibtisam.midlet
Pregabaline (calsium channel antagonist)
>SAGE
pregabaline really messes up with my memory though I tried it makes me rather foggy
ibtisam.midlet
The only anti anxiety that don't mess with memory (they even increase it) is SNRIs exactly strongest one, venalafaxine
ibtisam.midlet
Did you took any before
@ibtisam.midlet
Did you took any before
>SAGE
no, but I took NSI 189 before (for 3-4 months) and I feel my anxiety went up significantly after that, as well as my fear response
MEE6BOT
@>SAGE, you just advanced to level 1 respect++
ibtisam.midlet
Mislead, SNRIs us serotonin adrenaline's reuptake inhibitor
This the exact feeling
Face looking is 100%
>SAGE
?
ibtisam.midlet
Lool you will stay a boy
I mean the confident etc
@Potential
Alcohol being a weak Gaba A agonist probably helps.
Netizenne
Time to switch to pregnenolone
@ibtisam.midlet
Click to see attachment
Sirsadalot
Give me
1
@ibtisam.midlet
Face looking is 100%
Netizenne
She Korean you figure or what?
1
They’re expert biohackers over there lol
1
ibtisam.midlet
gigantic boobs between
veganpermanently
- complains of back pain all the time
- have to be stabilized while pounding
What is the benefit?
ibtisam.midlet
feminine feeling ᴗ
5thLeaf
Beauty
veganpermanently
Beauty is a side effect of function
Y'all confused as hell
Function of boob is breastfeeding. if you don't plan to do that it's a burden and looks ugly
ibtisam.midlet
@Sirsadalot
Give me
((odder_sea (glow-worm))
No
1
ibtisam.midlet
I was think its easy to run server without ban
but when you start being an admin you will find there a lot of variables you was not know about, define why admins have to ban
Mabus Tiefsee
discord admins must be ugly perverts who never leave their room, you are not fit for that job!
veganpermanently
- complains of back pain all the time - have to be stabilized while pounding What is the benefit?
Mabus Tiefsee
training back muscles would be a good idea - however how to do that without getting a wide back?
veganpermanently
Function of boob is breastfeeding. if you don't plan to do that it's a burden and looks ugly
Mabus Tiefsee
my personal assumption is that female human breast tissue above an B cub is like a peacock tail. And i want to know what happend in prehistoric times to give such a huge selection preasure for that?
ibtisam.midlet
Lets someone narcissistic attack you here and I'll get popcorn
instead of banning him
I have more tolerance then others
Mabus Tiefsee
nah narcissm is one of the dark traits i did not get
ibtisam.midlet
But temp ban mostly will be routine
Mabus Tiefsee
reminds me, in the quail to limusaurus biohacking server was a guy who "did not believe in dinosaures" because they are to big. We all where sad when he left the seerver. It was fun!
ibtisam.midlet
Better then you gain alot of friends and you found your self parama banned
Mabus Tiefsee
nah, friends are just an illusion. That way we don't have to admit to ourself that we use humans just for their benefits, while we help them to gain other benefits as well
veganpermanently
Function of boob is breastfeeding. if you don't plan to do that it's a burden and looks ugly
Netizenne
Function of boob is mostly fertility signalling tbh
>SAGE
also somewhat cultural
romans didnt like big boobs because they thought they were comical
komodo dragon
i LOVE big boobs
Alyen
Anyone here try j147
@>SAGE
romans didnt like big boobs because they thought they were comical
Ancient Roman apodesme, worn by both women and men, folded from a single piece of fabric. The breast band was a normal, if optional, item in a woman’s underwear. Women in Ancient Rome adopted a form...
roman sculptures in contrast with other civilizations, depicted ideal female forms with small comparatively small breasts
rome
india arround the same period
@>SAGE
romans didnt like big boobs because they thought they were comical
Potential
or big dicks that's why all of their male statues have small penises. Their theory was that the longer the penis the more savage/animalistic the person. A small penis was a sign of an intellectual.
1
@Potential
or big dicks that's why all of their male statues have small penises. Their theory was that the longer the penis the more savage/animalistic the person. A small penis was a sign of an intellectual.
((odder_sea (glow-worm))
I didn't want to contribute to the stereotype that otters are aggresive, savage predators... but alas.
1
ibtisam.midlet
Those don't have
@Potential
or big dicks that's why all of their male statues have small penises. Their theory was that the longer the penis the more savage/animalistic the person. A small penis was a sign of an intellectual.
fin
Or they actually just had small dicks and they knew that making that excuse would make future historians think that they were just lowballing their cocks
MEE6BOT
@fin, you have advanced to lvl 6 respect++
ibtisam.midlet
What yall think about nardil
Its maio a/b selective irrivisible inhibitor
can be ultimate biohacking tool
Instead of spending few k in increasing aadc activity by providing it co-factor , which will end with major oxidative problems due to increased catabolism
You can just inhibit monoamine catabolism
ibtisam.midlet
from then you will need 90% less bromantan then normal people
@ibtisam.midlet
from then you will need 90% less bromantan then normal people
>SAGE
how do I shrink my amygdala
@>SAGE
how do I shrink my amygdala
ibtisam.midlet
Nardil inhibit other enzyme that breakdown gaba and in therapy doses
Making it superior then other for social anxiety
For maio You have inhibited the primary moa for the body to breakdown
Due to irrrevisible inhibition The body need 14 days to refill maio stockage, and you need just one nardil attached to the enzme to unactivate it forever
>SAGE
are there any bad side-effects
ibtisam.midlet
The only thing that made maio inhibitors deprecated is that you can't eat cheese or any high thyramin food with it
Because thyramin is adrenaline releasing agent
Cause hypertension crisis
The effectiveness of maios was not able to make them stay in use, and replaced by lower efficiency less side effect alternative SSRIs
MEE6BOT
@ibtisam.midlet, you have advanced to lvl 14 respect++
ibtisam.midlet
To solve hypertension crisis
when your adrenaline baseline is 1 there thershould ~3 if you increased aderanaline more then it, then you get hypertension problems
The problem that maios increase it 5 times
What you need to do is antagonisting beta receptors sighlightly returning them to safe rang
@Mabus Tiefsee, you have advanced to lvl 7 respect++
@fin
I could have lived 70 years without seeing this
Sirsadalot
Same
Artichemillion
Hey everyone. Soonly I will synthesize research chemical called MPEP (similar to MTEP), that have shown its efficiency in treating addiction in mices. Does anybody interested in this RC despite that fact that no one human have tried this?
@Artichemillion
Hey everyone. Soonly I will synthesize research chemical called MPEP (similar to MTEP), that have shown its efficiency in treating addiction in mices. Does anybody interested in this RC despite that fact that no one human have tried this?
ibtisam.midlet
Did you tested mtep?
Lithium can be alternative for all of this if it is a start for you.
lithium cause learned hopelessness like mglue5 antagonist which mpep selective on it
https://en.wikipedia.org/wiki/Lithium_(medication)
Certain lithium compounds, also known as lithium salts, are used as psychiatric medication, primarily for bipolar disorder and for major depressive disorder. In these disorders, it sometimes reduces the risk of suicide. Lithium is taken orally.Common side effects include increased urination, shakiness of the hands, and increased thirst. Serious ...
This basically means that lithium have inhibition on that receptor which means the anti addiction effect of lethium is from there
Metabotropic glutamate receptor 5 is an excitatory Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. In humans, it is encoded by the GRM5 gene.
3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for ...
Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain. Subsequently, it was determined that fenobam acts as a potent and selective negative allosteric modulator of the metabotropic glutamate receptor subtype mGluR5, and it ha...
This study is to assess the effectiveness of low-dose lithium Carbonate (150 mg) augmentation or as a substitute for synthetic antidepressants and ant…
If modulating a feeling like hope reached its maximal benefits then you need to play with other one.
There a possibility that the effect is completely based on dose dependant curve realising the fact what "hope" is and expecting how it could cause anti addiction effect
You will need high doses.
@Netizenne
Click to see attachment
ibtisam.midlet
that type of aesthetic called hime gyaru
@ibtisam.midlet
that type of aesthetic called hime gyaru
Netizenne
I neeeed the hime gyaru haaaaat
ibtisam.midlet
After I learned "I promise"
I overused it for few weeks, just because how it sound
Now I have problem payback my promises
Lux ✨
LOL
ibtisam.midlet
The moment where Elon Musk made history
:The successful rocket launch appeared
:Then landing it to be reused
elon: where the shine , this is bad
:The rocket came back to work and landed smoothly
Ya we had a monster flying around here the other day too lol
@ibtisam.midlet
Click to see attachment
Mabus Tiefsee
filter ir truly as big eyes?
@Mabus Tiefsee
filter ir truly as big eyes?
ibtisam.midlet
its truly, you want one of it ?
treat her good!
between my 2nd account her is @elena.final_fail
Mabus Tiefsee
Nah, as big eyes are creepy in RL, my cousin and her 3 children got as big ones as well...
....besides eyes don't stay fresh for long outside the socket
@Mabus Tiefsee
Nah, as big eyes are creepy in RL, my cousin and her 3 children got as big ones as well... ....besides eyes don't stay fresh for long outside the socket
ibtisam.midlet
big eyes= aniiiiiiiiiime
Mabus Tiefsee
works only for asians
1
ibtisam.midlet
we need more collagen
@Netizenne
Function of boob is mostly fertility signalling tbh
veganpermanently
Yeah in today's day and age. But it does store a lot of fat which could come in handy in prehistoric times esp during breastfeeding. I think this is the reason why it signals fertility in the first place
ibtisam.midlet
Pig is credible animal
Give him your broken phone, trashbin, bag of expired substances and he will convert them to meat