Upload to #casual
You can add comments before uploading.
Hold shift to upload directly.
Text Channel

casual

Search

    Welcome to

    bio-tolerance

    This is your brand new, shiny server. Here are some steps to help you get started. For more, check out our Getting Started guide.
    Invite your friends
    Personalize your server with an icon
    Send your first message
    Download the Discord App
  1. !matrix approve
  2. BOT

    Thanks for your response! The matrix bridge has been approved.
  3. baby
  4. works now
  5. Nicee
  6. My server advance me lol
  7. Need a mods
  8. hi
  9. works now

    How to make invite links show in public server board
  10. hi

    It seems you installed a greeting bot
  11. ye
  12. How to do that
  13. How to make invite links show in public server board

    on disboard?
  14. i logged with other account and able to get invite link
  15. but its defernce is this okay?
  16. i would add it to disboard and top.gg
  17. just let see how things go now
  18. BOT

    Text from matrix
  19. /batch watch challenges
  20. /threads
  21. okay made a subreddit for this server
  22. to make sure we will not loss contact
  23. havent seen you for a bit
  24. joined the party.
  25. Glad you're here, .
  26. Glad you're here, Mado.

  27. pinned a message to this channel. See all pinned messages.
  28. What are the bots job here
  29. bumping the server automatically
  30. Or I'll use node.js
  31. I disabled welcoming messages to not bother user until I found how to make it exclud bots
  32. havent seen you for a bit

    I’ve been moving out to another country
  33. lots of packing driving and unpacking
  34. Hmmmm
  35. ಠ_ಠ
    Image
  36. BOT

    Greetings from South America, I am a physically disabled open source user who loves biohacking
  37. BOT
    Greetings from South America, I am a physically disabled open source user who loves biohacking

    Hiiiii welcome!!!
  38. BOT
    Greetings from South America, I am a physically disabled open source user who loves biohacking

    What is your interest in biohacking exactly +_+
  39. Hope you are life satisfied in way or other
  40. BOT
    Greetings from South America, I am a physically disabled open source user who loves biohacking

    Image
  41. BOT

    GG , you just advanced to level 4!
  42. any addition
  43. Greetings @everyone
  44. Greetings @everyone

    Hiiiiiii welcome +_+ you could travel the channels to see if you can benefits or help in something and read rules
  45. BOT

    GG , you just advanced to level 5!
  46. Hey guys
  47. New to the idea of altering my body positively. I've been addicted to some substances for about a decade now, and i'm on anti-psyche medication. Hoping biohacking and something like neuralink in future can help me regulate my chemicals but for now i'm looking here
  48. NAD+ IV has shown to decrease heroin intake by 80%
  49. psychedelics has anti addiction effect proposed generally
  50. Hey guys

    what's your addiction exactly
  51. THC, Nicotine and Caffeine
  52. Used to be on ritalin but no longer
  53. Used to be on ritalin but no longer

    That's not an addiction that life improving 😂
  54. Anyway coffee should not be counted But nicotine switch to vap I think it mostly you are addicted to hand to mouth move more then effect of nicotine if any This really hard to fix, due being dalta fos be has did positive reinforcements where he eliminated you ability to feel that bad smell of sig but made the spicy part of it more enjoyable by rewards sensitation , the same for vaping, when I get bored it almost impossible for me to stop thinking about nicotinic I'll just start generation unfair selective agreement advocate nicotine use.
  55. The problems with full of this is dalta fos b has half life ~4months That mean you need to stop for 4 months (no source its my xp) for craving potency to decrease "really" to half Which we can't even stop for few weeks do to logic changes.
  56. To this point there is not noticeably effective dfos b inhibitor. For me D3 antagonists was useless in this regard
  57. You might just try your luck with NAD+, just learn to inject first, small step by step and you done it.
  58. Blocked message.

    Look at emojis I stole Instagram one :emoji_1:
  59. You will get a lot of boys running over you with this
  60. Blocked message.

    this happen to voxelite, and constantly happen to me
    Image
    Image
    Image
  61. BOT

    GG , you just advanced to level 7!
  62. Yay you made it, !
  63. Yay you made it, Doctor Bonk!

  64. Click to see sticker

    :emoji_51:
  65. :emoji_51:

    I seen this emoji somewhere
  66. Very old, very nice
  67. Very old, very nice

    :emoji_50:
  68. :emoji_4:
  69. I stole it for sirsad server :emoji_5:
  70. I stole it for sirsad server :emoji_5:

    :emoji_52~2:
  71. :emoji_52~2:
  72. Welcome . Say hi!
  73. just landed.
  74. is here.
  75. Good to see you, .
  76. just landed.
  77. Welcome, . We hope you brought pizza.
  78. Everyone welcome !
  79. Everyone welcome Phonesavanh!

  80. Welcome, veganpermanently. We hope you brought pizza.

  81. Whats your news seojin
  82. Welcome, . We hope you brought pizza.
  83. Click to see sticker

    yoo
  84. Hiiiii
  85. joined the party.
  86. Damianze joined the party.

    Sticker, Wave
  87. Anyone here take paid commissions for DIY biohacking lab works?
  88. just slid into the server.
  89. Welcome, Meso. We hope you brought pizza.

  90. we would use this to increase toxicity threshold of NMDA/AMPA https://discord.com/channels/1001420842179239936/1001425425832091708/1003811119544152094
  91. How long has this server existed? Doesn't feel like many active people here
  92. A wild appeared.
  93. joined the party.
  94. Many active data here
  95. Its few days old and things going fast
  96. There 34 member's +_+
  97. :blahajhug:
  98. Many active data here

    Hope we can invite more people to this group who actually has experience of lab works.
  99. Image
  100. First Real girl beat anime ^~^
  101. potential therapy for who their problem is motivation and mood more then learning >>https://discord.com/channels/1001420842179239936/1004024673840922624
  102. just showed up!
  103. Welcome!!!!!
  104. Click to see attachment

    Lovely
  105. I have seen many anime to irl comparisons but this is the best
  106. welcome to netizenne the most cutest noots user out there, who his tiktok short never end
  107. just slid into the server.
  108. Новичок just slid into the server.

  109. Welcome, . We hope you brought pizza.
  110. 🍕
  111. Welcome, Maestus. We hope you brought pizza.

  112. Hey everyone, it's nice to be here.
  113. This place is incredible.
    Image
  114. i love the theme of this server...
  115. Hey everyone, it's nice to be here.

    wlcm +_+
  116. @everyone If you have a friend who capable to contribute in anyway, or have a problem trying to solve inviting them to the server appreciated Don't invite people who force thier opinion, or who are better at saying why things wouldn't work than how to make things work
  117. hopped into the server.
  118. Hes hopped into the server.

    Sticker, Wave
  119. just slid into the server.
  120. ひとり just slid into the server.

    Sticker, Wave
  121. A wild appeared.
  122. what r u using
  123. magnesium pidolate IM
  124. drugging your parents is the most intelligent thing you might do in your life
  125. drugging your parents is the most intelligent thing you might do in your life

    I’ve been thinking about trying this
  126. 😭
  127. Alzheimer’s runs in my family amoung the women My mom could use DFO or something
  128. She’s gone vegetarian though so she might have reduced her iron anyways as is
  129. It's highly beneficial especially for bisexual and sub's users
  130. BOT

    GG , you just advanced to level 9!
  131. It's highly beneficial especially for bisexual and sub's users

    ???!???
  132. Why what
  133. Parents will always try to force their outdated standards on you saying biology is waste of time, then you use this biology
  134. Who the winer now
  135. Why what

    Homo/bi have a hard time generally with parent due they don't want to understand that sexual ordination is a thing
  136. Also drug users ofc
  137. And religious leave
  138. what
  139. :emoji_51:
  140. its not their life its your life, I'll kill for freedom
  141. :emoji_51:
  142. The must stupid type is that parents who see you as project, give it money in childhood and he return it then
  143. sounds like my mom
  144. I can't wait to leave my moms place
  145. goodbye she annoying asf she can be helpful but she really be drivin me up the wall
  146. BOT

    GG , you just advanced to level 1!
  147. goodbye she annoying asf she can be helpful but she really be drivin me up the wall

    She should support you, don't let her bother you much, otherwise you hit a point where there is no forgiveness
  148. Better live alone if you can, and stay in contact with her
  149. She’s gone vegetarian though so she might have reduced her iron anyways as is

    I'm considered the freelancer doctor in my family lol
  150. She should support you, don't let her bother you much, otherwise you hit a point where there is no forgiveness

    yes
  151. Leave your fam
  152. Never answer phone calls
  153. Never visit
  154. Disappear
  155. one day once i get enough money ill move north from where from my current location
  156. Go tell the police not to react if they report you missing
  157. no she knows I want to move out but im just broke atm trying to get my self together
  158. That wasn't advice to u
  159. BOT

    GG , you just advanced to level 1!
  160. It's advice to all men
  161. lok
  162. ok
  163. Also
  164. If u want some dignity
  165. Refuse all inheritance
  166. You can just drug them with some Empathogen meds
  167. Now my breakfast reach me to bed
  168. Yay you made it, !
  169. Good to see you, .
  170. The must stupid type is that parents who see you as project, give it money in childhood and he return it then
  171. sounds like my mom
  172. I can't wait to leave my moms place
  173. goodbye she annoying asf she can be helpful but she really be drivin me up the wall
  174. BOT

    GG , you just advanced to level 1!
  175. goodbye she annoying asf she can be helpful but she really be drivin me up the wall

    She should support you, don't let her bother you much, otherwise you hit a point where there is no forgiveness
  176. Better live alone if you can, and stay in contact with her
  177. She’s gone vegetarian though so she might have reduced her iron anyways as is

    I'm considered the freelancer doctor in my family lol
  178. She should support you, don't let her bother you much, otherwise you hit a point where there is no forgiveness

    yes
  179. Leave your fam
  180. Never answer phone calls
  181. Never visit
  182. Disappear
  183. one day once i get enough money ill move north from where from my current location
  184. Go tell the police not to react if they report you missing
  185. no she knows I want to move out but im just broke atm trying to get my self together
  186. That wasn't advice to u
  187. BOT

    GG , you just advanced to level 1!
  188. It's advice to all men
  189. lok
  190. ok
  191. Also
  192. If u want some dignity
  193. Refuse all inheritance
  194. You can just drug them with some Empathogen meds
  195. Now my breakfast reach me to bed
  196. Yay you made it, !
  197. Good to see you, .
  198. Yay you made it, motomoto!

  199. Good to see you, veganprimate.

  200. Welcome . Say hi!
  201. Stack post tiiiime
  202. Prepare yourself
  203. Rapamycin Aniracetam Piracetam Bromantane Bacopa 24% bacosides 100 mg modafinil Curcumin Cacao Ginkgo biloba Quercetin with bromelain ALCAR Na r ala Reduced glutathione NAC Agmatine Shiitake mushroom Enteric coated peppermint Digestive enzymes for all the aforementioned L-glutamine B12 sublingual methylcobalmin B6 p5p sublingual Thiamine hcl Methylfolate Potassium citrate Boron Selenium Molybdenum One meal a day
  204. The stack is for inducing extremely high pattern recognition, synesthesia, enjoyment of life which will assess my addictive tendencies, socialization skills. The stack is clearly higy effective as i just typed all this after being up for 42 hrs straight and I worked 9 hrs at the beginning of starting this wakefulness I am impaired by high functioning autism, severe adhd and I have brain hypertension which inhibits traditional stimulants from being useful, depression, anxiety, addiction, immunocompromization (I've had molluscum contagiosum for about 4 years), chronic fatigue
  205. I am, quite obviously, attempting to assess every issue I have in my life
  206. My work performance has also obviously improved and I'm getting a raise soon
  207. I also did a cerebrolysin cycle 4 months ago that seemed to fix my severe visual sensory issues
  208. I also quit a 1-4 grams per day phenibut habit 5 weeks ago w minimal wd using majority of aforementioned stack
  209. [Detailed Info about each needed]
  210. Yea I'll do that and doses after I fucking sleep lmfao
  211. All of them at once? Microcoding, co-factor problem, crazy half life, there just 3 considered something others can't suck dick of coffee
  212. Normally I wouldn't even go this far but I was in the mood
  213. Wat
  214. How do you suck coffee penis
  215. Tell me the ways of jedi
  216. Most of em at once yea
  217. BOT

    GG , you just advanced to level 1!
  218. Bet
  219. I'm pro
  220. Fuck me I'm not even tired
  221. I haven't even taken modafinil for 38 hrs
  222. And it was 100 mg
  223. Oh yea, fhe list is order of importance
  224. That should help some
  225. I listed my issues, one should be able to deduce what I'm using everything for
  226. Er
  227. Many things at least
  228. Obvi most are multi faceted
  229. I'll also add that my main strengths are long term iq and pattern recognition
  230. Short term memory has been greatly improved by using mild 5ht2a agonists like aniracetam and agmatine
  231. Thats Ampa and nmda-
  232. To archive noticeable effect on ht2a upper dose by 200
  233. The selective targeted not dirty drug
  234. Cacao makes aniracetam 5ht2a effects more prominent
  235. Aniracetam is placebo without cacao
  236. It upregulates some serotonin, I'll send study after I sleep
  237. Rapamycin Aniracetam Piracetam Bromantane Bacopa 24% bacosides 100 mg modafinil Curcumin Cacao Ginkgo biloba Quercetin with bromelain ALCAR Na r ala Reduced glutathione NAC Agmatine Shiitake mushroom Enteric coated peppermint Digestive enzymes for all the aforementioned L-glutamine B12 sublingual methylcobalmin B6 p5p sublingual Thiamine hcl Methylfolate Potassium citrate Boron Selenium Molybdenum One meal a day

    Moda agmatine and mushroom, that the only will work
  238. That's simply wrong
  239. Aniracetam is potent for me
  240. I took 260+ sub's
  241. With all the interactions going on it'd be foolish to assume some of the norms apply
  242. I have detailed data about each
  243. I took 260+ sub's

    Subs?
  244. Substance
  245. That's too many
  246. Even imo
  247. I do miss etiz for brain hypertension ngl
  248. Surprisingly effective
  249. Why is rapamycin so fucking stim
  250. Half life ig
  251. Did any of this made you clean you room
  252. Yea but then I got it dirty again lmao
  253. And haven't bothered since
  254. I clean the store at work amazing
  255. I do miss etiz for brain hypertension ngl

    Hypochondria
  256. But i still don't see a point in cleaning my room
  257. Hypochondria

    Making assumptions w inadequacy info
  258. Prove to me benzos aren't anti hypertensive then get back to me
  259. You don't have hypertension imo
  260. I'm open to debate but only if it's hempfil
  261. Lmao
  262. Useless server ig
  263. L8r
  264. BOT

    GG , you just advanced to level 2!
  265. Your assuming you know my life when you've talked to me for 60 min of my life total
  266. You realize the arrogance in doing that right?
  267. Sirsad levels
  268. Rip you
  269. Rip you
  270. I'm sorry i can fix my problems and you cant
  271. I'm arrogant im
  272. Ik
  273. But I demonstrate actions to prove it
  274. I'm welcome to talk but not if you don't listen to what I say
  275. Lmk if you wanna listen, for now I'm just gonna keep working on myself
  276. I like you, but I don't like when people don't try and view things objectively or try and understand a situation
  277. And instead just assume, hurt aforementioned person, then go on with life w no care
  278. I actually did have hypochondria at a point
  279. So what, I havent in 3 years
  280. Try and use that to support your claim idrk
  281. Do you know why all hypertensives cause me severe headaches and make me tired? Unless I take anti hypertensives to assess the issue?
  282. Give me an answer and I'll thoroughly consider it
  283. I've been investigating this myself for 6 months and not on my own, bc they would be useless bc self bias
  284. No one has a better idea
  285. So shoot your load
  286. You don't even know the health issues I've been through lmao
  287. Why does lad cause me a severe headache that makes me unable to think regardless of how many 5ht2c antagonists I take
  288. I can go on
  289. But I'm bored
  290. And this is futile it appears
  291. All I can do is what I've been doing, but if you genuinely have ideas please let me know
  292. I am open to constructive criticism
  293. Look
  294. I am, however, not open to destructive criticism
  295. What symptoms you have from this list
  296. ocd Perfectionism Fast talking Mania Addiction Hypochondria Hyperactivity Attention deficits Impaired productivity
  297. Most of thats more adhd symptoms than hypochondriac
  298. I never fast talk or get mania unless I take rapamycin
  299. Hence why you've never seen me doing what I'm doing rn
  300. you do it now
  301. And?
  302. 😅
  303. Bro
  304. Your determining I have hypochondria from one altered state
  305. When I have 6 months of looking into my issue being brain hypertension and getting support
  306. The best treatment for me was risperidone 0.33mg
  307. It will treat the real problem that induced all of this
  308. Why would I kill my cognition when I finally improved it after 3 years?
  309. Smh
  310. Your too biased
  311. I've tried seroquel fwiw
  312. Not risperidone to be fair
  313. D2 give you smartness and stole all other life expect from you
  314. Your assuming way too much for something you know nothing abt
  315. I take no d2ergics except aniracetam rn I believe
  316. You can vet that claim
  317. Only ris are selective in D2 and it will lost it if you go over 0.33
  318. Bro you can't even type
  319. And you've said like 8 statements
  320. And you think your suggestion will fix my issue when your demonstrating as much issue
  321. I'll try somn you suggest but not pharma route
  322. So suggest an alt
  323. Idk if relevant but I normally sleep 10 hrs a day
  324. Its unfair to force someone on something even if I'm not just sure, I'm one of them
  325. I haven't been able to research In 3 years
  326. I've researched more today than past months
  327. Past 2 days*
  328. Apologies
  329. I'm sorry I'm getting heated
  330. Its mild d2 blockage
  331. I like you and I don't want to argue
  332. How about this
  333. I'll look into your ideas
  334. BOT

    GG , you just advanced to level 3!
  335. But I can't get a risp script rn
  336. Wait
  337. Bc I may lose my amp script which I sell for 450 a month
  338. And I need that money for noots
  339. Bc I may lose my amp script which I sell for 450 a month

    That's fictional I could never be a drug dealer idk where the 450 a month comes from
  340. What's funny is on any other day I would have just left this server bc this uhhh argument? But today I can actually explain my thoughts
  341. It's a new feeling
  342. Ugh I gotta buy a po box again reee
  343. Oh well I need more moda anyways
  344. Start 0.25 or you will get tortured by it
  345. I quit memantine a month ago btw fwiw
  346. It started causing brain fog
  347. Wouldn't that downregulate d2 if anything?
  348. Chronic use I mean
  349. It will cause short term upregulation
  350. Define short
  351. Bc it's been at least 4 weeks
  352. Aka withdrawal symptoms
  353. And I don't take uridine
  354. I don't get mem wd
  355. I just nic becoming stronger
  356. I was surprised wds from gabaergics didn't get worse when I quit it
  357. I'll also mention phenibut doesn't help with the presumed hypertension headaches
  358. And if hypochondriac it should?
  359. And alcohol also worsens them
  360. Only benzos help
  361. Of gaba drugs
  362. You talk much switching from topic to topic, causing people see you annoying= no relationships
  363. Of gaba drugs

    Directly Block d2 stimulant anxiety
  364. I didn't get stim anxiety all my life until a complicated health incident
  365. In fact I had panic attacks going to school if I didn't take my adderall
  366. You talk much switching from topic to topic, causing people see you annoying= no relationships

    Untreated adhd + hypo(mania)?
  367. That makes as much sense imo
  368. However your right ppl have been less prone to talk to me the past 12 hrs
  369. Idk I just think there's a lot of other options to consider
  370. Why so focused on hypochondriac in particular is my main question
  371. Because I have that
  372. Which means it's a very biased suggestion
  373. Hence why I kinda raged
  374. I hate biases
  375. I genuinely have hypertension if I don't take herbs for it
  376. That's easily determinable
  377. 140/115 range
  378. Tested?
  379. Body hypertension is easy to asses
  380. Yes
  381. Doctors literally were concerned abt my blood pressure but always attributed it something else, like thay I was in the heat for an hr before coming in
  382. 140/115 is not considered hypertension
  383. But it's always abt that high if i dont take strong anti hypertensive herbs
  384. Well it's elevated regardless
  385. And I took ris and it caused severe hypotention
  386. If it was hypochondriac than shouldnt every substance I take make me feel a headache?
  387. Ok explain to me risps pharma aside from D2
  388. Which mean D2 control blood pleasure , increase blood pleasure when agonised
  389. Hmmm
  390. I want a study for thag claim
  391. That's more extrapolated than my belief
  392. Ok explain to me risps pharma aside from D2

    Just don't take more then 0.33mg or you will lost all your biohacking interest, 2mg and you are a Farmer
  393. Helps irritability associated with autistic disorder.
  394. It lower your standards like nothing
  395. Now I will agree thay currently I do suffer from that
  396. Should have led with that
  397. And also I understand I need to take suggestions from friends more bc they are often righr
  398. However I am arrogant but working on it
  399. Sighlightly Lower standards the you now are good, at least you will accept to fuck the shemale you talked about even if it was not 100% perfect
  400. D2 is destroying all your life expect and you still advocating it
  401. Yea sirs told me the same but why do they cause motivation to do shit I need to do then
  402. Like a college application
  403. Everything I've read says d2 bad but everything I experience says d2 good
  404. I've been quite confused abt that
  405. Admittedly
  406. its just increase motivation for science
  407. AND I HAVE NO MOTIVATION FOR ANYTHINF NORMALLY
  408. BOT

    GG , you just advanced to level 4!
  409. I literally sit around and watch TV all day normally
  410. And shitpost
  411. You are driving you hit someone killed it, because your was thinking about biology when you drive
  412. It helps me when I'm at that point but your likely right that I can get better by dropping the d2 increasers now bc other issues have been assesed
  413. It was likely just a helpful cope when I was at my worst
  414. If this is accurate
  415. Which that I can agree with accepting as a high possibility
  416. You gotta lead with this shit tho lmao
  417. Don't save the good shit for the end
  418. I literally was abt to leave a while ago
  419. And now I'm glad I've stayed bc DISCOVERY REQUIRES EXPERIMENTATION
  420. And actually I've always liked you
  421. If someone else had approached like this I would have left
  422. Hence excess d2 increasing autism irritability
  423. But I already had that autism connection meme w you
  424. I'm very glad this went well, that's a new one
  425. Tbf when I don't take anything for d2 I just remain neutral in these things
  426. And ignore em
  427. You can go to any doctor say you was on ris and anafranil and he will prescript it for you
  428. But I've had same doc for numerous years
  429. What's anafranil?
  430. Also I'm concerned abt risperidone inverse serotonergic action but I'm noob on inverse agonism
  431. I have to cuck 5ht2c
  432. And need 5ht2a uncucked
  433. Ris should not be take by other people in any situation
  434. Ik
  435. Hence concern
  436. You need to put your D2 on 6/10 You are 9/10 other people are 5/10
  437. I get that
  438. But answer aforementioned q
  439. The inverse serotonergic agonism
  440. Wat I expect from that
  441. Subjectively
  442. it block bad serotonin receptors
  443. 5ht2a good
  444. 5ht2c terrible
  445. Subjectively

    See receptors function db serotonin part
  446. And most inverse agonism for 2a
  447. Db?
  448. serotonin receptor are ball in park
  449. Elaborate
  450. Yea they up and down-regulate like daily it seems
  451. Risperidone is poison
  452. I have to cuck 5ht2c

    agomelatine works. 1 mg subL before bed for 15 mins
  453. And need 5ht2a uncucked

    memantine works. 1 mg in the morning can do oral. using more cancels the cognitive enhancement, tho it becomes nice for some introspective work about 15 mg. but I guess you know that. Anyway the 1 mg dose is nice combo with modafinil
  454. Hence excess d2 increasing autism irritability

    memantine nooks my irritability. I guess the higher doses permanently teached me how to stay calm despite unwanted scenarios happening
  455. I still get irritable it's only easier to control my reaction to the emotion
  456. Message could not be loaded.

    modafinil takes care of this. some weak filtered coffee. ginkgo
  457. I take this back it's kinda based
  458. PubMed
    Tardive dyskinesia is a neurological disorder characterised by involuntary and purposeless movements affecting any part of the body. These movements typically occur in the oro-facial area and the patient is usually unaware of them. There are inconsistent findings in the literature on the risk factor …
    Image
  459. When you block d2 the body notice and start up regulating dopamine by blocking its catabolism
  460. This will lead to agonist D1
  461. Which is fairly good
  462. Follow stack as addon at least those can suck dick of coffee
  463. What would be halpfull from me to the stack is magnesium kilo dose, see benefits and side effects
  464. When you block d2 the body notice and start up regulating dopamine by blocking its catabolism

    MAO B expression was upregulated, it did not block catabolism, it increased it
  465. What would be halpfull from me to the stack is magnesium kilo dose, see benefits and side effects

    I'd rather not
  466. PubMed
    Recent experiments have shown that: 1) A chronic 10 month daily administration to rats of the benzodiazepine (BDZ) receptor antagonist, flumazenil (FL; 4 mg/kg in drinking water), from the age of 13 through 22 months, significantly retarded the age-related loss of cognitive functions, as ascertained …
    Image
  467. Mg is good but the form you take is v bad
  468. GABA transaminase inhibitor
  469. compare effects to valproate
  470. MAO B expression was upregulated, it did not block catabolism, it increased it

    It should be the opposite
  471. BOT

    GG , you just advanced to level 10!
  472. Look here
  473. DA receptor antagonists enhance the activity of AADC https://biosignaling.biomedcentral.com/articles/10.1186/1478-811X-11-34
    BioMed Central
    Parkinson’s disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself is strongly linked to oxidative stress as its degradation generates reactive oxygen species (ROS) and DA oxidation can lead to endogenou...
    Image
  474. What you think
  475. It should be the opposite

    it might be neutral effect tho, the vesicles protect against MAO B oxidation
  476. if VMAT2 and MAO B are increased simultaneously that's a desireable state
  477. I'd rather not

    If you see something have more benefits then harm , take it
  478. because it prevents autoxidation which is the worst type of dopamine metabolism
  479. Give me cazino were 60% win 40% loss, I'll sell my underwear gumbel it
  480. If you see something have more benefits then harm , take it

    the problem is short term vs long term. I was taking lemonbalm daily before. felt good but looking back it took it's toll
  481. CBD as well. all GABAergics do this. hence why I'm now recovering with GABA antagonists
  482. I don't go by feeling anymore
  483. I find the most optimal intervention and use that to my benefit.
  484. it generates better cognitive and emotional states than chasing feelings in the end anyways
  485. BOT

    GG , you just advanced to level 2!
  486. most of what I do now has no trade off
  487. the doses are lower than anyone else uses, for example the agomelatine. No one has done this before me yet the study is up there and the results are clear
  488. the problem is short term vs long term. I was taking lemonbalm daily before. felt good but looking back it took it's toll

    Companies try to make clean substance where side effect dose is very high then good effect, you can just microdose what you want , and the longterm effect will stay good
  489. modafinil takes care of this. some weak filtered coffee. ginkgo

    Both are in my stack but I'm poor rn and only risk moda on work days until I order more
  490. Had to cut my dose in half to 100 mg to ensure I'd have enough for a bit
  491. Had to cut my dose in half to 100 mg to ensure I'd have enough for a bit

    I take 30 mg
  492. it works without tolerance for about a week then I stop
  493. I just don't take daily
  494. I surprisingly have no tolly issues w moda
  495. I've been using 4-6x a week for a few months
  496. well u don't take it daily
  497. it takes a long time to develop tolerance even on such a small dose I take
  498. Yea but I develop tolerance to substances fast so I'm still surprised
  499. moda has a unique MoA
  500. Inflammation is my only guess bc nmda antagonism doesn't help
  501. it's not the DRI effect
  502. but it is dopaminergic for sure
  503. Yea orexin?
  504. it's a vesicular release agent
  505. orexin release agent as well
  506. What I love abt it is its not really hypertensive
  507. you have to have a lot of vesicular release to develop tolerance
  508. it's natural in a way
  509. Please stop talking about my vehicles in casual, it makes me uncomfortable
  510. / s
  511. electrically evoked monoamine release
  512. Please stop talking about my vehicles in casual, it makes me uncomfortable

    why is everyone like this
  513. I love electricity, sometimes I put the toaster in the bath
  514. makes me shut down
  515. It's a funny word I'm sorry
  516. You may continue I'm listening and will confine shitpostinf to external servers
  517. rage quit a vegan server yesterday
  518. if I can't geek out I won't even talk to you
  519. idc
  520. Oh I want you to geek out
  521. Wait was it vegan permanently server
  522. Wait was it vegan permanently server

    i am VP
  523. no it was some goofy vegan dating server
  524. they don't let you use the R word on yourself
  525. have pronoun tags
  526. etc
  527. they get offended by your beliefs
  528. imagine that
  529. I can't even identify with vegan groups nowadays
  530. the only thing we have in common is that we avoid animal abuse
  531. Lmao at work I say "HEY WE DONT USE THAT WORD HERE" when someone says retard
  532. It's a kitchen
  533. but other than that we're a diff species
  534. It's a kitchen

    kek
  535. that's the funny part
  536. everyone and their mother snorting K in the toilet but you can't use the R word
  537. everyone and their mother snorting K in the toilet but you can't use the R word

    LMAO HOWD YOU KNKW I DID THIS
  538. Nah we can use the r word
  539. I use it
  540. bcs it's a kitchen
  541. BOT

    GG , you just advanced to level 3!
  542. all kitchens are the same
  543. drug holes
  544. No one does dissos at my work
  545. Even the smart mfers tried telling me nitrous can kill you easily
  546. Everyone drinks on the job tho
  547. And smokes
  548. BOT

    GG , you just advanced to level 5!
  549. well tbf it was meant as a parabole
  550. Basic bitch shit
  551. K is for horses.
  552. no amph?
  553. I did struggle to close when nearly holing on too much bathroom k once lmfao
  554. I can't flip my amp script at work surprisingly
  555. moda is the perfect kitchen drug
  556. as long as the ventilation is on point
  557. because otherwise you'll heat out quick
  558. I need heat for cognition
  559. I volunteer to do hoods in 105F
  560. And that takes an hr
  561. moda increases thermogenesis
  562. Yea if I don't sweat I don't think well
  563. if u have brown fat it can feel hellish
  564. I'm white
  565. I'm gonna guess that's not what you meant
  566. no
  567. no
  568. it's fat with metabolic properties
  569. kinda based
  570. white fat browns when exposed to cold
  571. I see
  572. increases cold tolerance
  573. Hmmmm
  574. but also makes you heat out if 5ht2a is activated at high ambient temp
  575. I used to be very tolerant to cold and hated heat
  576. Then it flipped
  577. u lost brown fat
  578. When I was tolerant to cold my diet was trash
  579. I've also ruled out thyroid ofc
  580. drink some olive oil and spend time in a walk in freezer
  581. Seeing as I have chronic fatigue I had to make sure I wasn't hypothyroid
  582. fasting mimicking diet, rinse and repeat
  583. FUCK THE WALK INS
  584. So cold
  585. I am doing lower fat rn bc drug test later this month but after that I'll try
  586. I normally eat lots of peanut butter
  587. I maintain subQ fat
  588. these gymbros insecure idiots
  589. if I can see my abs it's time to crush the plate
  590. Oop
  591. Yea my issue likely correlates to abs becoming more pronounced
  592. I'm amazed I couldn't sleep more
  593. Rapamycin is wack
  594. it is
  595. i get these stim effects as well
  596. well no one did until I told everyone about it
  597. I'm curious how it will impact my treatment resistant molluscum contagiosum
  598. so I tend to think it's a meme
  599. I had never heard of it being a stim
  600. And my fatigue is also due to health issues
  601. I guess it is then
  602. was uncomfortable when I snorted it
  603. 5 mg oral is fine
  604. So it makes sense I'd hyperrespond to this effect, and in reality it's probably also increasing my ability to get stimmed from rest of stack bc health is better
  605. I can't afford to oral that
  606. I'd run out fast
  607. Do you have a source for it atm?
  608. a bit too much autophagy paired with fasting mimicking diet tho
  609. I need that for a bit I'd think
  610. has muscle pains, a headache
  611. I have a bit of cancer in my genes
  612. but I guess it did clear some cancerous cells
  613. yesterday I had a customer on chemo
  614. that's horrifying
  615. worth every intervention
  616. But yea I stayed up for 44 hrs unintentionally bc rapa, and could only sleep 4.5
  617. I didn't even moda yesterday
  618. did u snort it
  619. Yea
  620. Also yea my mom has a rare leukemia and severely low platelet count
  621. I don't think it's a good idea now
  622. Her platelets were in single digits once
  623. get some pomiferin
  624. Amd then she got thyroid cancer
  625. my ex had ovary cancer
  626. :emoji_51:
  627. Oof
  628. That sounds painful
  629. Coffee causes me headaches if I have a cup, but for some reason I need 1/4 to 1/2 cup a day for some reason
  630. bitch gets what she deserves
  631. Ok it's stack time
  632. puts on timer
  633. I decided to stop eating after 5 pm
  634. Any idea of ultra low dose naltrexone is a terrible idea with rapamycin
  635. I decided to stop eating after 5 pm

    That's smart
  636. No idea
  637. BOT

    GG , you just advanced to level 2!
  638. Most ppl eat too late
  639. Any idea of ultra low dose naltrexone is a terrible idea with rapamycin

    should be good
  640. Ok that's gonna be my final attempt to cure my viral infection
  641. I give up if that combo w everything else I take doesn't work
  642. It's been lime 6 years
  643. I can't have sex bc of it
  644. lyme disease?
  645. I tested myself recently
  646. negative
  647. I may have thay too but haven't tested
  648. But no, benign but awful molluscum contagiosum
  649. oh
  650. Only supposed to last behind 2 years in severely immunocomp ppl
  651. I've had over 6
  652. I don't have sex to prevent shit like that
  653. past 4 years
  654. IM A VIRGIN
  655. had one relapse
  656. I got an std and I'm a virgin.
  657. regretted it instantly
  658. BOT

    GG , you just advanced to level 4!
  659. got up and left
  660. IM A VIRGIN

    50 bucks and no standards can change that
  661. how the fuck did you manage to remain virgin
  662. Lmao no I'm actually hot
  663. I've had to turn down offers for sex
  664. ur a strong man
  665. my guy
  666. i thought I was monking out
  667. I don't lift
  668. Kek
  669. But yea I was in my dream girls bed
  670. u do women
  671. She wanted it
  672. I was too autistic to explain my situation
  673. I got an std and I'm a virgin.

    sounds like responsible patents....
  674. if everyone was like u all women would be saints
  675. So it was just a cuddle sesh
  676. Then she tried again in the morning lmao
  677. Put my hands on her tits
  678. slut
  679. Then when I obviously wasn't gonna fuck she said she had to go see her sister
  680. slap
  681. spit
  682. spank
  683. We met at a bar so probably tbfh
  684. That was my first time ever going to a bar and j wasn't even 21 lmao
  685. And I went home with a 10
  686. Then when I obviously wasn't gonna fuck she said she had to go see her sister

    next Tinder match
  687. codename
  688. the std, an incurable one?
  689. Mines treatment resistant
  690. Severely
  691. that sucks
  692. Tell me abt it
  693. I wasn't an addict until I got it
  694. trying sonething crazy to cure it with biohacking or did you acept your fate?
  695. Trying something very crazy
  696. The kitchen sink
  697. try histidine
  698. overload BCAAs
  699. limit tryptophan
  700. and bomb rapamycin oral
  701. all at the same time
  702. I notice serotonin upregulation worsens it
  703. Aka cacao
  704. indeed IDO is antiviral
  705. nooking IDO will provide an edge to viruses
  706. IDO?
  707. if you need any crazy new ideas, tell me the std - i always come up with crazy ideas... besides i am limited extremly with biohacking because of my country. Therefore theory and stoneage biohacking is all i got...
  708. indoleamine dioxygenase
  709. if you need any crazy new ideas, tell me the std - i always come up with crazy ideas... besides i am limited extremly with biohacking because of my country. Therefore theory and stoneage biohacking is all i got...

    It's molluscum contagiosum, you can scroll up for additional context
  710. Current plan is focused on low dose naltrexone + rapamycin
  711. And rest of my stack
  712. wait, it is a pocks strain? Immunity against one pocks version often helps against others. Did you already trow some close but more harmless pocks strains into the kitchen sink?
  713. Uhhh no
  714. How would I even
  715. Buy em from Rothschild?
  716. Lmao
  717. monkey pox home delivery service, just ask some gay dudes if they got connections. The worst orgys should have them
  718. disgusting
  719. and asking your doctor for an old pox vaccine, the they could still work (first pox vaccine was just a weak pox strain. That's the reason many got a scar at the incection site)
  720. disgusting

    yes
  721. oh and high dose vitamin C, some cink and high dose vitamin D Just for boosting your immune system.
  722. Yea i take all those
  723. 50 k IU Lesss goo
  724. Oh I forgot to include reacta c in my stack
  725. ....like i sayd, crazy ideas are my speciallity...
  726. Rapamycin Aniracetam Piracetam Bromantane Bacopa 24% bacosides 100 mg modafinil Curcumin Cacao Ginkgo biloba ALCAR Na r ala Reduced glutathione NAC Shiitake mushroom Enteric coated peppermint Digestive enzymes for all the aforementioned B12 sublingual methylcobalmin B6 p5p sublingual Thiamine hcl Methylfolate Potassium citrate Boron Selenium Molybdenum One meal a day
  727. knock on wood my zoster infection hasn't returned for 4 yrs
  728. I guess all I need to do is avoid bitches
  729. all it needed for me (even during my most horny time as teenager) for loosing all interests in her. Blisters on the lips....
  730. BOT

    GG , you just advanced to level 4!
  731. all it needed for me (even during my most horny time as teenager) for loosing all interests in her. Blisters on the lips....

    simplex is nothing compared to zoster
  732. zoster gives you debilitating back pain
  733. you can't get up even
  734. ever move is like a thousand daggers through your spine
  735. sounds awfull
  736. it is evil
  737. attacks your nerves in the spinal cord
  738. some people have these pains permanently
  739. and no painkiller helps it
  740. don't forget to freeze a sample of infectious material as backup plan in case you need it one day
  741. nooked it with acyclovir
  742. should probably stock up on femcyclovir in case it comes back
  743. and avoid bitches, that hour of fun is not worth any std, even the not as serious ones....
  744. ofc
  745. I'm monk
  746. no PMS
  747. yeah a guy has to go his own way, i agree
  748. also no porn
  749. that's literal brain damage
  750. hold on....
  751. to be fair it's not really strong science but it does feel like it
  752. no women and no porn? How do you manage your hormones? I can have either or - but both, how?
  753. no women and no porn? How do you manage your hormones? I can have either or - but both, how?

    great inhibitory control
  754. I've upregulated my GABA neurons to the point I can enjoy not induldging compulsions in a way
  755. was it before the infection as well? Pain reducing your dribes makes sense. Otherwise you migt want to check your hormon levels. Just to be sure.
  756. was it before the infection as well? Pain reducing your dribes makes sense. Otherwise you migt want to check your hormon levels. Just to be sure.

    no this happened only after I took my stack
  757. before that I couldn't even manage to not smoke weed
  758. ah direct brain alteration, yeah that explains it
  759. avoid GABAergics
  760. introduce GABA antagonists and release inhibitors
  761. result is stronger inhibitory neurotransmission over time
  762. no, can't do that. That would make reproduction difficult
  763. reproduction of what
  764. human ofspring
  765. I don't intend to have children but I'm curious what you're on about
  766. I don't have a clue
  767. I'm busy planning world domination I don't have time for little gremlins
  768. I'm busy planning world domination I don't have time for little gremlins

  769. sperm donations for those who want to raise my ofspring for me minimal risk & investment, maximal offspring numbers. I am switching from a K strategy to an R strategy in reproduction. If just one out of ten children will develop good, it is a win - simple math.
  770. if I can't indoctrinate them there is no point
  771. I'm busy planning world domination I don't have time for little gremlins

    that's why i said freeze infectious tissue! Use it as starting point and make an airborn version. In case ypu need a hostage, take the whole world!
  772. gremlins are ideal cult followers but you need to actually do it
  773. if I can't indoctrinate them there is no point

    the question is, do you think nature or nurture. I believe it is 60-90% nature and the remaining nurture is neglectable.
  774. the question is, do you think nature or nurture. I believe it is 60-90% nature and the remaining nurture is neglectable.

    nurture all the way
  775. in that case, become a teacher
  776. in that case, become a teacher

    no that's just adding a drop to a sea it does nothing
  777. kindergardenteacher
  778. I need them isolated until they're fully grown up and trained
  779. they see the children more often than the parents if you exclude sleeping time
  780. I need teachers tho'
  781. BOT

    GG , you just advanced to level 5!
  782. hard to brainwash 10k children all by yourself
  783. hard to brainwash 10k children all by yourself

    tell that to pokemon. Make a game, you can hide anything in there and it works better as everything the teachers would teach anyway
  784. tell that to pokemon. Make a game, you can hide anything in there and it works better as everything the teachers would teach anyway

    ur right should prolly take a more legally sound approach
  785. and hide the thing afzer 3h of playtime. That way the parents won't find out. The problem DnD made, they showed the satanic stuff during character creation!
  786. I'm shaking
  787. I've been on rapamycin 3 days and my viral infection I've had for 6+ years is going away
  788. One of the largest bumps I had is just gone
  789. GONE
  790. One of the largest bumps I had is just gone

    nice
  791. it's potent
  792. make sure to do other biohacks to prevent bacterial infections
  793. S. montana oil aromatherapy
  794. GONE
  795. found it
  796. Hmmmm it's anxiolytic for me
  797. Does bring down my childhood leaning toward hypolanic bipolar
  798. But I was in depression for past 7 years and constantly abused drugs so it's worth the trade
  799. I also have never been diagnosed with bipolar
  800. S. montana oil aromatherapy

    Alternatives?
  801. I'm sure I have something helpful at home
  802. ❤
  803. Hi fren
  804. I just found 7 amp
  805. Free money
  806. That's literally $105 in my pocket
  807. It's a good week
  808. I also am now a synesthetic
  809. BOT

    GG , you just advanced to level 6!
  810. At least w current stack
  811. Another long term goal achieved
  812. Bro getting rid of this fucking nft is a huge pain
  813. I got it for free
  814. Ok I need crypto, who wants to buy piracetam or aniracetam
  815. Alternatives?

    search antiobiotic herb. I found this one to take care of Streptococcus aureus
  816. Everyone welcome !
  817. Everyone welcome kowau!

  818. search antiobiotic herb. I found this one to take care of Streptococcus aureus

    Oh I already cured my recurrent mrsa
  819. I actually was getting close to needing an amputation lmfao
  820. Entire leg was severely red and antibiotics made it spread more
  821. the thing is
  822. Researched and found articles on Manuka honey, asked the doctor abt it and he advised against it, did it anyways and next day doctor goes "idk what your doing but keep doing it"
  823. Fuck doctors lmao
  824. S. auerus is a natural part of the nasal microbiome
  825. I'm aware
  826. secretes toxins which directly access the brain
  827. I meant I cured getting recurrent infections
  828. Hm didn't know that part
  829. which is why I wanted to nook it
  830. and found the oil to do it
  831. But you'd have to do that daily
  832. Forever
  833. And ever
  834. And ever
  835. ever echoing in the distance
  836. yeah well I like S montana smell
  837. I don't mind my house smelling like that all the time
  838. Researched and found articles on Manuka honey, asked the doctor abt it and he advised against it, did it anyways and next day doctor goes "idk what your doing but keep doing it"

    classic doctor behavior
  839. if there's something they were not thought in school
  840. the automatic response is to say no
  841. true NPC behavior
  842. tho' there may be legal liabilities about this
  843. so that's one reason for this
  844. the automatic response is to say no

    The problem is they're also taught to do that
  845. They're actually essentially taught not to think in a way
  846. I ate an Arum sp. leaf once
  847. Independently
  848. I am a leaf
  849. came choking to my doc
  850. they told me 'we don't know what it is go home'
  851. Idek what that is fam this isn't going well
  852. Sounds right
  853. I'm surprised they didn't just give you charcoal
  854. They should always do that if they don't know
  855. At worst it'll have a neutral effect
  856. At best it'll work
  857. that's the most poisonous plant one could consume in Europe
  858. I could have died if I only ate a bit more
  859. They don't have Datura in europe?
  860. this is more poisonous than datura by far
  861. But more fun inbet
  862. S
  863. nah
  864. it just makes you choke
  865. and you die
  866. Some people like that tbh
  867. Weird people
  868. my ex
  869. stupid bitch
  870. What's the moa
  871. Did u kill her
  872. /s
  873. idk I'll look it up
  874. Too much kink choking
  875. Lmfao
  876. no she begged me
  877. I slapped her
  878. 'why did you slap me'
  879. 'because you're a dumb bitch'
  880. proceeds with the pounding
  881. Thud
  882. Thud
  883. Thud
  884. Door opens
  885. wtf
  886. the MoA is literally calcium oxalate
  887. brazing your throat
  888. oh
  889. so this promotes absorption of cyanoglycosides
  890. FUN
  891. funny thing
  892. my diet is literally slowly poisoning me
  893. That's common
  894. Too many oxalates?
  895. Too many oxalates?

    I'll eat over 2 g by the end of the day today
  896. :emoji_23:
  897. that spinach champignon stew
  898. NOT SPINACH NOO
  899. The fucking worst
  900. You can literally feel the oxalates
  901. yeah well IDC
  902. because I made the best recipe in the world
  903. eats more cacao
  904. you can't go beyond this no way
  905. I'm a cook
  906. So your probably right
  907. me too
  908. but I choose not to work for a cuck
  909. That's why you bully your coworkers into complacency ezpz
  910. I owe lawyers and fam
  911. Sp I got to
  912. who did you kill
  913. Your ex gf...
  914. good riddance
  915. thanks
  916. Yea now pay up
  917. oh
  918. meet me in the back street
  919. don't carry weapons
  920. NO DONT PAY IN SEX
  921. I need money
  922. I'll pay in DEATH
  923. Why does the government take your taxes just to return them at the end of the year
  924. it does?
  925. Uh oh I'm getting too smart
  926. In America
  927. idk it send me the thing about getting my tax return I never go
  928. maybe I should
  929. You should just get a check
  930. Well you have to file
  931. always thought it was a misunderstandin
  932. Lmao
  933. You should use turbo tax this year
  934. I'm fairly certain your breaking the law lmfao
  935. If you have a job
  936. why
  937. Bc America is dumb
  938. I'm not in usa
  939. Then idk
  940. Ugh I don't wanna go to work
  941. Wyd
  942. Wyd

    eatin spinach champignon stew
  943. BOT

    GG , you just advanced to level 6!
  944. just slid into the server.
  945. Hi guys student have 3 diploma: have an associates in mathematics and science and a bachelors in both biology with a concentration in genetics and biochemistry
  946. Its mostly being benfitical to have at least one , a none freelancer biologist
  947. thank you for the introduction! I’m grateful to be part of the community and I look forward to collaborating on projects and contributing! 🙂
  948. See channels to know what we are researching, if you could contribute will be awesome +_+ Or even get some unusual info might help you
  949. Of course, I’ll be sure to check them out! Thanks again for the intro to the community
  950. hopped into the server.
  951. agomelatine works. 1 mg subL before bed for 15 mins

    look here
  952. Jesus stayed dead for atleast a quarter of a year before returning revived
  953. BOT

    GG , you just advanced to level 1!
  954. Rip Jesus for being chased away :despair:
  955. He spoke the truth
  956. Yay you made it, !
  957. Yay you made it, JKL!

    Sticker, Wave
  958. Welcome . Say hi!
  959. Welcome maze.yaeger. Say hi!

    Sticker, Wave
  960. Image
  961. Hello
  962. How is everyone
  963. 🦧
  964. 🦧
  965. Hi
  966. I'm gonna use my based stack to date the hottest girl at work
  967. And it's gonna work
  968. She's a server and I'm a cook so if shit doesn't work it could be worse
  969. What are you up to yaeger
  970. Jaja
  971. Hi, just looking for servers
  972. is here.
  973. Hi
  974. Who is the leader of this domain
  975. I'm top of the member list rn so I am
  976. What do you need
  977. Who is the leader of this domain

    Always assume it's the most active member
  978. It's accurate in this case
  979. Good
  980. :785513382215811122:
  981. that spinach champignon stew

    Cadmium
  982. Who is the leader of this domain

    Its me
  983. Your cadmium
  984. I knew it
  985. just showed up!
  986. 89 pretends 180 just showed up!

  987. hello do you want to make a channel for hair loss
  988. Nope
  989. Its too niched
  990. Take boron
  991. Works annoyingly well for my facial hair
  992. Glad you're here, .
  993. Glad you're here, komodo dragon.

  994. Yoyoyo
  995. What's on the menu
  996. Not vegan food
  997. go to improving >>sub>>hair loss Do your research there
  998. Click to see attachment

    Who is this person? You?
  999. nope, but one day will do that :emoji_51~1:
  1000. Anyone here take paid commissions for DIY biohacking lab works?
  1001. BOT

    GG , you just advanced to level 1!
  1002. I'll take paid commisions
  1003. Can't say I can do the latter
  1004. Anyone here take paid commissions for DIY biohacking lab works?

    It seems not 🐤
  1005. I am glad I got a fitting role
  1006. FUCK
  1007. is here.
  1008. any input xx
  1009. hopped into the server.
  1010. blank hopped into the server.

  1011. Alyen is here.

  1012. look who jumped
  1013. You are wlcm between
  1014. Read rules
  1015. :emoji_50~1:
  1016. I can make you unmentionable if you want
  1017. I can make you unmentionable if you want

    wdym
  1018. Seems You don't like to mentioned rendomly by users
  1019. 😭
  1020. it doesn't actually matter
  1021. do you even do sublingual probiotics
  1022. 🤐
  1023. BOT

    GG , you just advanced to level 1!
  1024. you got that power?
  1025. 🤣
  1026. Mr paranoid
  1027. 😭

    :notetake:
  1028. Does anyone know how artificial eggs and sperms generate from stem cells even make sense?
  1029. Stem cells carry the full number of chromosomes in its DNA, while eggs and sperms only carry half.
  1030. Generated* From stem cells? If I understanded your question, then stem cells need to splited to get half DNAs like sperm and eggs
  1031. In other way if you mean how stem cells can be generated from egg and sperm or not, then just join them and you get full DNA
  1032. you can even ganerate full DNA just from half DNA (chromatid) there recessive and dominant genes there, but still not important, you can just use the same chromatid twice
  1033. Does anyone know how artificial eggs and sperms generate from stem cells even make sense?

    for cloning an extinct animal, yeah maybe . For every other practical application, there are better ways
  1034. and it always depend on the goal, what do you want to achieve?
  1035. Yo
  1036. CEO of CEO
  1037. CEO of CEO

    yo
  1038. yo

    Sup
  1039. :kannaWave:
  1040. Everybody here
  1041. Leave sirsa to die alone
  1042. I heard he likes McDonald’s :eSobbing:
  1043. Leave sirsa to die alone

    I should have known you were orchestrating this behind the scenes, you diabolical heathen
  1044. I should have known you were orchestrating this behind the scenes, you diabolical heathen

    Who is u
  1045. Who is u

    I am the clown with the tear-away face
  1046. I should have known you were orchestrating this behind the scenes, you diabolical heathen

    thank you for the kind words odder
  1047. thank you for the kind words odder

    It's is my honor to bestow upon you my encouraging prose
  1048. It's is my honor to bestow upon you my encouraging prose

    which demon suddenly imbued you with the power of silky smooth lyrical spell mastery
  1049. which demon suddenly imbued you with the power of silky smooth lyrical spell mastery

    I been spitting these lyrical enigmas since I could remember
  1050. I been spitting these lyrical enigmas since I could remember

    splitting minds like a sigma, makes me wanna get better
  1051. splitting minds like a sigma, makes me wanna get better

    Degenerate rhymes, I'm a stigma, tell yo ho ma she can ligma
  1052. BOT

    GG , you just advanced to level 1!
  1053. Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_;
  1054. We should probably nook D2/D4 to proactively prevent that imo, they are involved in novelty seeking iirc
  1055. But is the novelty seeking of D2/D4 applicable to social relations????
  1056. Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_;

    Too late, fomenting a coup d'état in Nicaragua
  1057. Too late, fomenting a coup d'état in Nicaragua

    NOOOOO :PepeHands:
  1058. Blank and Bonk have already left nootopics for greener lands
  1059. Such damage has already been done
  1060. We need cohesion!!!!!!!
  1061. Blank and Bonk have already left nootopics for greener lands

    Together? Holding hands?
  1062. Together? Holding hands?

    B-team :Love: :Love: :Love: :Love: :Love: :Love:
  1063. Skipping into the sunset?
  1064. Ya exact
  1065. BOT

    GG , you just advanced to level 2!
  1066. Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_;

    r u joking
  1067. I'm too autistic to tell
  1068. We need cohesion!!!!!!!

    not on Sirsad's server
  1069. in general, yeah wouldn't hurt
  1070. with a delta male leader eh
  1071. Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_;

    :yus:
  1072. regarding novelty seeking
  1073. r u joking

    Does it matter, there is knowledge to be gained in adopting the narrative and the motivations that come with it
  1074. Wow u guys are super mods
  1075. Does it matter, there is knowledge to be gained in adopting the narrative and the motivations that come with it

    there is no novelty seeking activity more complex than biohacking
  1076. Wow u guys are super mods

    I will moderate your LIFE There is no escaping this server
  1077. :lip:
  1078. Ok
  1079. there is always new pathways
  1080. and even the old pathways always have new interactions
  1081. these people that left the space didn't do so bcs there is no more novelty in biohacking
  1082. bcs there always is and it's not even hard to come across it
  1083. so you don't even need to seek we're all just showered in novelty
  1084. these people left for 2 reasons
  1085. they got dissapointed by people or their biohacking success or scared of sides for some reason
  1086. Perhaps there is a sweet spot for how much novelty seeking you get. Or perhaps different pathways effect novelty seeking within different domains -like maybe oxytocin increases novelty seeking within “things” but not people.
  1087. Perhaps there is a sweet spot for how much novelty seeking you get. Or perhaps different pathways effect novelty seeking within different domains -like maybe oxytocin increases novelty seeking within “things” but not people.

    seeking new people for the novelty is just low IQ
  1088. Idk not really Meet the right person and you can stumble upon insane wealths of knowledge
  1089. well yeah
  1090. but you did that for the knowledge not the person
  1091. Does novelty seeking, divergent thinking, creativity and aberrant synaptogenesis all have something in common???
  1092. can put paranoia in that category
  1093. I think sirsad said psychedelics cause massive aberrant synaptogenesis like it was a bad thing, -but aren’t the abnormal/divergent connections of these substances where the creativity comes from???????
  1094. just make the brain go brr if u ask me
  1095. I think sirsad said psychedelics cause massive aberrant synaptogenesis like it was a bad thing, -but aren’t the abnormal/divergent connections of these substances where the creativity comes from???????

    Yeah, as long as you don't overdo it, and alternate with pruning protocols, I forsee mostly benefits
  1096. How do different dopamine receptors modulate aberrant synaptogenesis ? Could the novelty seeking of D2 and D4 be considered that?
  1097. Excited to find that Matrine may be a viable pruning aid, I'll pick some up in a few months with the ND winter sale
  1098. just make the brain go brr if u ask me

    brrrrrrrrrrrrerrrrrrrraaaiiiiin
  1099. Ya I am not sure about pruning tbh
  1100. Is probably necessary but I think you’ve got a limited amount of connections to prune or something maybe
  1101. what I'm sure about psychs is that they produced a permanent hallucinatory state for me
  1102. I can't say it's bad tho
  1103. also I'm sure this state is largely underreported as many users don't even know what it is or that it came from psychs
  1104. Is probably necessary but I think you’ve got a limited amount of connections to prune or something maybe

    Gets rid of the ones you don't need/reinforce. Can help with learning new habits/unlearning old habits Excessive use of neurogenics will probably lead to autism-like cognitive patterns over time
  1105. Image
  1106. Image
  1107. the problem with neurogenesis is that the neurons and synapses start stacking on top of one another
  1108. eventually u end up with a smooth brain
  1109. so the only way to really get gains is to trepanate and grow another brain outside
  1110. heh my pfp finally lived up to it's name
  1111. Disintegrins are what enable cancer cells to drill through tissues and invade/connect different regions I think. Maybe you can grow the brain without it all becoming connected somehow by researching these.
  1112. I could be wildly misrepresenting their role tho
  1113. Def double check that
  1114. today I had the weirdest trip
  1115. I stopped riding for a second
  1116. had the sensation of falling sideways
  1117. then extreme nausea and cold sweats for 20 mins
  1118. kinda like food poisoning
  1119. Hmmm that does not seem good lol
  1120. ye
  1121. weirdest thing is
  1122. It’ has been very hot out here lately
  1123. after the 20 mins like nothing happened
  1124. I can't handle the heat anymore for sure
  1125. it's fucking torture
  1126. Click to see attachment

    It is weird how this model almost suggests autism results from too much pruning tbh ……….
  1127. Like there’s something off there
  1128. It is weird how this model almost suggests autism results from too much pruning tbh ……….

  1129. It is weird how this model almost suggests autism results from too much pruning tbh ……….

    wth is that anyways
  1130. been staring at it for 2 mins straight
  1131. only to notice the title last
  1132. wth is that anyways

    They use slime molds to model Tokyo subways system and now they’re using slime molds to mode human cognitive diversity
  1133. I guess
  1134. it's fucking torture

    https://en.m.wikipedia.org/wiki/Siesta I am trying to learn how to siesta
    A siesta (from Spanish, pronounced [ˈsjesta] and meaning "nap") is a short nap taken in the early afternoon, often after the midday meal. Such a period of sleep is a common tradition in some countries, particularly those in warm-weather zones. The "siesta" can refer to the nap itself, or more generally to a period of the day, generally between 2...
    Siesta
  1135. BOT

    GG , you just advanced to level 3!
  1136. I’ve found I tend to have a midday period where I’ll laze in bed and kinda rest, but I don’t ever go so far as to actually sleep much
  1137. I just sit in bed all cozyyy
  1138. https://en.m.wikipedia.org/wiki/Siesta I am trying to learn how to siesta

    that's easy for me
  1139. I just quit caffeine and modafinil
  1140. it's siesta all day every day
  1141. I have 20 mins of productivity
  1142. https://en.m.wikipedia.org/wiki/Siesta I am trying to learn how to siesta
  1143. Image
  1144. Click to see attachment

    now compare to modafinil graph
  1145. now compare to modafinil graph

    Straighter
  1146. idek
  1147. Click to see attachment

    That is a pretty good model of my day tbh
  1148. Straighter

    the 2 PM drowsiness is hyperstimulation for me
  1149. it's siesta all day every day

    Me too :despair: :despair: :despair: :despair: :despair: I must have chronic fatigue or something
  1150. This is why working until later in the day is crucial since you just get back home tired
  1151. BOT

    GG , you just advanced to level 1!
  1152. I need to get up and clean the apartment or do 150 pushups to feel normal again
  1153. The graph is hours after waking btw
  1154. The graph is hours after waking btw

    the dip is around 2 PM
  1155. if u wake up at sunrise
  1156. Yeah
  1157. Click to see attachment

    If the Siesta is a summer phenomena, does that mean there’s less of a dip in this chart during the winter? Maybe melatonin or vitamin D control this.
  1158. What even is the biggest regulator of seasonal changes actually
  1159. Image
  1160. What even is the biggest regulator of seasonal changes actually

    serotonin
  1161. serotonin production and release are dependent on retina light exposure
  1162. Waoh no way what the heck
  1163. Waoh no way what the heck

    yeah it's pretty obvious even in everyday life
  1164. Waoh no way what the heck

    btw did u see my write up
  1165. plenty of old ideas in a single article
  1166. btw did u see my write up

    Where’s it at????? I need to lurk in rocket chat more
  1167. Where’s it at????? I need to lurk in rocket chat more
  1168. Gvane Brain!!!!!! :Waow:
  1169. I need to up my writing game tho
  1170. so many redundant words
  1171. https://en.m.wikipedia.org/wiki/Siesta I am trying to learn how to siesta

    Have you noticed that many people wake up with anxiety after an afternoon nap. 🤔
  1172. Have you noticed that many people wake up with anxiety after an afternoon nap. 🤔

    it's a hit or miss for me
  1173. never anxiety
  1174. but sometimes it provides rest, sometimes it makes me even more tired
  1175. if I have nice dreams it's usually the most rejuvenating
  1176. lucid dreaming esp
  1177. I feel like the key is to stay conscious throughout the whole thing
  1178. but sometimes it provides rest, sometimes it makes me even more tired

    You have to factor in the circadian rhythm. I've found with myself that a (max) 30min rest doesn't usually trigger anxiety.
  1179. BOT

    GG , you just advanced to level 2!
  1180. total loss of consciousness would be hard to get back from
  1181. A combination of L-theanine, Taurine and Phenibut is nice when I really need good quality sleep.
  1182. You have to factor in the circadian rhythm. I've found with myself that a (max) 30min rest doesn't usually trigger anxiety.

    I don't think it's about duration at all. I could sit in meditation for 4 hours and not feel any more tired at all. But if I lose consciousness for more than a single REM cycle it's over
  1183. I hope creatine helps my mitochondria 🤞
  1184. Day 2 today
  1185. I hope creatine helps my mitochondria 🤞

    maybe slightly
  1186. I hope creatine helps my mitochondria 🤞

    I'm potentially buying a photobiomodulation laser device soon and I'll update you on that. 👍
  1187. we'll see
  1188. BOT

    GG , you just advanced to level 8!
  1189. I need a way to quantify my experiments on this
  1190. but it's hard due to the fact that my training is inconsistent
  1191. I hope creatine helps my mitochondria 🤞

    I dont think theres any benefit to creatine if you eat enough beef
  1192. btw creatine HCL is a better idea IMO
  1193. if you're doing oral
  1194. Why
  1195. I hope creatine helps my mitochondria 🤞
    PubMed
    Sleep deprivation (SD) causes oxidative stress in the hippocampus and subsequent memory impairment. In this study, the effect of near-infrared (NIR) photobiomodulation (PBM) on learning and memory impairment induced by acute SD was investigated. The mice were subjected to an acute SD protocol for 72 …
    Image
  1196. Oohhhhh How effective is it???????
  1197. thiamine is an idea u know
  1198. I suffer alotta sleep deprivation
  1199. Oohhhhh How effective is it???????

    It's most likely very effective but we shall see.
  1200. like 1000 mg thiamine HCL and 100 mg benfo sulbu or alli thiamine
  1201. I will be conducting tests, as always.
  1202. and like emi said
  1203. snort the P5P
  1204. pyridoxine HCL should not be legal to sell
  1205. thiamine is an idea u know

    Thiamine is clutch. Sulbutiamine (pure nootropics) TTFD/allithiamine and Benfotiamine are the bee's knees
  1206. issa secret unkind people will never uncover
  1207. because they're drenched in their pride and self assurance
  1208. So simply increasing vmat is not good enough, I also need to improve mitochondria in order to provide them the energy to load the vesicles???? What is your treatment doc!!!!????????
  1209. So simply increasing vmat is not good enough, I also need to improve mitochondria in order to provide them the energy to load the vesicles???? What is your treatment doc!!!!????????

    indeed
  1210. increasing VMAT2 without improving mitochondrial health concurrently will lead to random disorders
  1211. throw a dice
  1212. shizo
  1213. bipolar
  1214. Elliot Overton has me convinced that a cycle of high dose thiamine, say 500mg+ of the fat soluble forms, is useful for upregulating enzymes/cellular energy. If you make it a cycle of Sulbutiamine, you can increase D1 dopamine receptors too:emoji_49:
  1215. Elliot Overton has me convinced that a cycle of high dose thiamine, say 500mg+ of the fat soluble forms, is useful for upregulating enzymes/cellular energy. If you make it a cycle of Sulbutiamine, you can increase D1 dopamine receptors too:emoji_49:

    u know
  1216. the body is not a fat blob
  1217. unless you're a fat blob
  1218. the brain does accept fat soluble subs via diffusion without transporter action
  1219. but the brain is not the only target of thiamine
  1220. increasing VMAT2 without improving mitochondrial health concurrently will lead to random disorders

    IMO may, if not most, chronic diseases are to some degree mediated by impaired mitochondrial functioning
  1221. the brain does accept fat soluble subs via diffusion without transporter action

    I'm on board with those points, bit I'm not tracking 100% what you are trying to communicate here
  1222. IMO may, if not most, chronic diseases are to some degree mediated by impaired mitochondrial functioning

    indeed, as all transporters use cellular energy
  1223. thiamine is an idea u know

    Ttfd
  1224. Oh someone said that
  1225. I'm on board with those points, bit I'm not tracking 100% what you are trying to communicate here

    just substantiating the stack. btw it's not my invention
  1226. the inventor is unknown
  1227. eventually I will develop a life-back serum without stims
  1228. just instant mitochondrial rockin and poppin
  1229. mitochondria go brrrr
  1230. sr9009 or PQQ for mitochondria health
  1231. sr9009 or PQQ for mitochondria health

    both pls
  1232. I'm still hesistant about snorting PQQ
  1233. looks both appealing and dangerous at the same time
  1234. absolutely no info online
  1235. btw prob with sr9009 is the short half life
  1236. If I were to start with just 1, pqq is prob safer and more effective right?
  1237. u have to dose it every few hours
  1238. at the very least
  1239. u have to dose it every few hours

    Ouch what a pain
  1240. If I were to start with just 1, pqq is prob safer and more effective right?

    yes
  1241. cheaper as well
  1242. u have to dose it every few hours

    I think id probably use it more on a case by case basis in that case, just taking it when I wanna get stuff done
  1243. I think id probably use it more on a case by case basis in that case, just taking it when I wanna get stuff done

    not much acute effect by itself from what I've seen
  1244. never tried it
  1245. Any relevant genes you reccomend checking to see if I have?
  1246. BOT

    GG , you just advanced to level 4!
  1247. never tried it

    Blanks been using it but idk if they knew to take it every few hours :/
  1248. Honestly I might not bother with it now that I know that
  1249. Any relevant genes you reccomend checking to see if I have?

    well when it comes to this it's not gonna influence treatment anyways
  1250. I'm with Greger on that one
  1251. if you can spend money on something fun why spend it on a test
  1252. if the result is at least somewhat likely to affect your life choices sure take it
  1253. like if you were biten by a tick and your area has frequent lyme disease
  1254. test ASAP
  1255. I'm still hesistant about snorting PQQ

    I'd move up to Skq1 before snorting PQQ tbh. I take PQQ in the AM with ALCAR
  1256. BOT

    GG , you just advanced to level 2!
  1257. I'd move up to Skq1 before snorting PQQ tbh. I take PQQ in the AM with ALCAR

    they don't do the same thing
  1258. PQQ is special there's no small molecule alike
  1259. Phenelizen will be bulletproof for neurotransmitters availability
  1260. Its very effective for social Anxiety
  1261. they don't do the same thing

    What are your targets with IN PQQ?
  1262. Good read
  1263. 👍
  1264. 7/10 would boof again
  1265. What are your targets with IN PQQ?

    DJ-1. If u find another DA neuron penetrable compound that prevents DJ-1 oxidation you're golden. DJ-1 is a master regulator of VMAT2 expression. If the transporter is dysfunctional, oxidation rises and DJ-1 acts as a chemical antioxidant. The only way to stop the process is to introduce another antioxidant that is capable of DJ-1 protection which is only PQQ.
  1266. serotonin production and release are dependent on retina light exposure

    sometimes I feel a lot more productive if I just spend the whole day in the dark what does this mean 🧐
  1267. DJ-1. If u find another DA neuron penetrable compound that prevents DJ-1 oxidation you're golden. DJ-1 is a master regulator of VMAT2 expression. If the transporter is dysfunctional, oxidation rises and DJ-1 acts as a chemical antioxidant. The only way to stop the process is to introduce another antioxidant that is capable of DJ-1 protection which is only PQQ.

    Aha. I knew PQQ was OG. Suck it Sirsad
  1268. BTW it's not like people have invented this. PQQ is endogenous and this is it's job in the brain
  1269. DJ-1. If u find another DA neuron penetrable compound that prevents DJ-1 oxidation you're golden. DJ-1 is a master regulator of VMAT2 expression. If the transporter is dysfunctional, oxidation rises and DJ-1 acts as a chemical antioxidant. The only way to stop the process is to introduce another antioxidant that is capable of DJ-1 protection which is only PQQ.

    why hasn't anyone talked about this before 😩
  1270. How big of a difference are we going to see from IN administration versus oral? What's the Ideal dose for IN and Oral? I've been using 20mg in the AM with my ALCAR for synergistic effect and to prevent TMAO bacteria from colonizing.
  1271. sometimes I feel a lot more productive if I just spend the whole day in the dark what does this mean 🧐

    Probably your 5ht2c is too sensitive to serotonin or you have too much oxidation, your kynurenine pathway is too activated. Dark metabolizes 5HT via AANAT preferentially.
  1272. ✍️
  1273. why hasn't anyone talked about this before 😩

    Bcs I am the VMAT2 God
  1274. How big of a difference are we going to see from IN administration versus oral? What's the Ideal dose for IN and Oral? I've been using 20mg in the AM with my ALCAR for synergistic effect and to prevent TMAO bacteria from colonizing.

    I don't recommend IN no one has tried this before
  1275. There are no studies either. Unexpected results may occur esp in terms of nasal cavity
  1276. Bcs I am the VMAT2 God

    Image
  1277. I don't recommend IN no one has tried this before

    Ok. Making sure I wasn't missing the boat on something awesome here. What do you feel is the ideal oral dose/schedule for general purposes?
  1278. Ok. Making sure I wasn't missing the boat on something awesome here. What do you feel is the ideal oral dose/schedule for general purposes?

    20 mg
  1279. 20 mg

    Once daily?
  1280. Yes
  1281. Morning
  1282. And what's your opinion on Ubiquinone/Ubiquinol? I've been taking them off and on for years, after learning that vegans tend to have lower levels. Currently on 100mg of vitacost ToCoQ10 with tocotrienols and bioperine in the AM, allegedly sun exposure converts it to ubiquinol in the bloodstream. Have some qunol ubiquinol I take on cloudy days
  1283. I like it but it's too expensive. I'd like to do other things with my money now. Maybe when I'm older
  1284. And were you the one recommending chlorophyll? I picked up a bunch of chlorophyllin from LEF, allegedly activated by sunlight, some people theorize may assist with production of ATP, but haven't seen anything solid on it. I take 100mg with the ToCoQ10 in the AM
  1285. Yo

    :emoji_51~1:
  1286. I like it but it's too expensive. I'd like to do other things with my money now. Maybe when I'm older

    I picked up two years worth from vitacost for about $60 on sale
  1287. And were you the one recommending chlorophyll? I picked up a bunch of chlorophyllin from LEF, allegedly activated by sunlight, some people theorize may assist with production of ATP, but haven't seen anything solid on it. I take 100mg with the ToCoQ10 in the AM

    I recommend everyone to eat leaves
  1288. BOT

    GG , you just advanced to level 3!
  1289. Chlorophyll is one of the nice parts of leaf tho', holds a few biohacking secrets
  1290. I recommend everyone to eat leaves

    I eat tons of greens, But allegedly very little of intact chlorophyll makes it to the bloodstream
  1291. I eat tons of greens, But allegedly very little of intact chlorophyll makes it to the bloodstream

    Well the thing is chloroplasts have more than chlorophyll
  1292. :emoji_50~1:
  1293. I think juicing should release the contents
  1294. Wheat grass juice is nice if prepared fresh and well
  1295. I think juicing should release the contents

    I wonder if consuming with a bit of Sunflower lecithin may improve uptake?
  1296. I wonder if consuming with a bit of Sunflower lecithin may improve uptake?

    Cool idea. Without ultrasonication no but... When life gives you lemons Make a cake
  1297. I like to throw a teaspoon In with my green smoothies, I wondered if the vitamin released enough energy to liposomalize any fraction of the nutrients. I was under the impression the lipophyllic/emulsifying nature of lecithin would help with intestinal uptake even if not fully complexed,
  1298. BOT

    GG , you just advanced to level 3!
  1299. Time to start experimenting with this stuff. Liposomal everything, nano/microemulsions, etc.
  1300. Took 1500 mg MgCl yesterday before sleep. Bowel movement is now perfect
  1301. I Guess I was deficient
  1302. I've always wondered if you could make liposomal/PC DHA (Ala krill oil) with algae oil and lecithin via ultrasonic complexing, which may be beneficial for APOE carriers die to their poor transport of non-PC DHA across the BBB
  1303. I've always wondered if you could make liposomal/PC DHA (Ala krill oil) with algae oil and lecithin via ultrasonic complexing, which may be beneficial for APOE carriers die to their poor transport of non-PC DHA across the BBB

    PC no, liposomal yes but what this would do IDK
  1304. PC no, liposomal yes but what this would do IDK

    I think the AvailOM Algal should accomplish the same feat, so sort of a moot point maybe
  1305. I think the AvailOM Algal should accomplish the same feat, so sort of a moot point maybe

    ALA is superior anyways
  1306. ALA is superior anyways

    I know some if the literature suggests this, though I've always been concerned about relying on endogenous conversion for DHA, mostly from the positive studies of DHA intervention (though individuals were almost certainly not vegans) Related, I've seen it referenced that curcumin, and I think longvida specifically, may increased endogenous conversion of ALA into DHA in the brain
  1307. But also that the conversion is fairly oxidative in nature, so may result in excess ROS compared to exogenous, pre-formed DHA As in, 10 units of ALA have to be oxidized to get 1 unit of DHA. I'll try to find the source on that
  1308. For many years I was having several teaspoons per day of Flax/Chia, but slightly concerned about anti-androgenic effects of flax, as I'm (or was, last time I was checkedbtwo years ago) borderline low-T High-E
  1309. But also that the conversion is fairly oxidative in nature, so may result in excess ROS compared to exogenous, pre-formed DHA As in, 10 units of ALA have to be oxidized to get 1 unit of DHA. I'll try to find the source on that

    it doesn't matter. the compounds themselves are antioxidants so this reaction is actually protecting everything else from oxidation. It's like saying don't take PQQ because it oxidizes. Of course it does - it's an antioxidant
  1310. For many years I was having several teaspoons per day of Flax/Chia, but slightly concerned about anti-androgenic effects of flax, as I'm (or was, last time I was checkedbtwo years ago) borderline low-T High-E

    dietary phytoestrogens will not influence endogenous hormone levels. If anything they should reduce estrogen, but they don't
  1311. but. it's probably best to get an oil press and press your own oil from flax, not for the phytoestrogens but the cyanogenic glycosides. A few teaspoons will not be toxic but if you want real gains from ALA you need to press it
  1312. dietary phytoestrogens will not influence endogenous hormone levels. If anything they should reduce estrogen, but they don't

    I don't believe that Flax's anti-androgenic effects were mediated primarily by phytoestrogen. I consider phytoestrogens to be generally positive for men and women
  1313. why not just buy flax oil? it oxidizes quickly when it's not protected by the seed shell. You need to consume it within 4 hours of pressing. Which is why homepress is best. It's also the cheapest, tho' the upfront cost is about 300 USD.
  1314. why not just buy flax oil? it oxidizes quickly when it's not protected by the seed shell. You need to consume it within 4 hours of pressing. Which is why homepress is best. It's also the cheapest, tho' the upfront cost is about 300 USD.

    I normally just used flax ground at home In a coffee grinder- the ALA is stable for over 6months at room temperature, which was irrelevant as I'd keep it in the fridge in a Mason jar and make a new batch every few weeks
  1315. I normally just used flax ground at home In a coffee grinder- the ALA is stable for over 6months at room temperature, which was irrelevant as I'd keep it in the fridge in a Mason jar and make a new batch every few weeks

    yes even when ground it is stable because the shell contains antioxidants, but when you separate the oil it oxidizes within hours
  1316. yo this is what I was talking about the other day
  1317. why do people DM me with small talk
  1318. do I appear like such a person
  1319. 'hey dude' 'what's good bruh'
  1320. yes even when ground it is stable because the shell contains antioxidants, but when you separate the oil it oxidizes within hours

    Yeah, and all the fiber benefits/blood sugar mitigating effects are from the ground seeds, not the oil
  1321. 'hey dude' 'what's good bruh'

    I feel like those are spam accounts
  1322. I've actually tried to talk to them a few times and they are unable to do so and just keep repeating small talk phrases
  1323. Imma start doing that again, Aldi's sells the seeds for dirt cheap. Adding a tablespoon to every meal/smoothie
  1324. Really good for giving a smoothie a thick. Ice-creamy texture
  1325. I've actually tried to talk to them a few times and they are unable to do so and just keep repeating small talk phrases

    I don't even know what to respond in the case it's a real person
  1326. ask them if they have done anything interesting recently
  1327. BOT

    GG , you just advanced to level 2!
  1328. usually shuts them up 😂
  1329. ask them if they have done anything interesting recently

    I asked if it was a bot
  1330. Really good for giving a smoothie a thick. Ice-creamy texture

    yes I prepare a smoothie like this every day: 200 g Banana 200 mL Soy milk 20 g Flax seed 30 g Chia seed 3 g Ceylon Cinnamon Water until consistency is desireable
  1331. I omit the ceylon and soy milk while fasting mimicking and use just 1 banana. less seeds as well
  1332. yes I prepare a smoothie like this every day: 200 g Banana 200 mL Soy milk 20 g Flax seed 30 g Chia seed 3 g Ceylon Cinnamon Water until consistency is desireable

    Do you pre-grind the flax?
  1333. ask them if they have done anything interesting recently

    he said he's not a bot, he comes in peace and proceeded with the small talk
  1334. he said he's not a bot, he comes in peace and proceeded with the small talk

    Kill it with fire
  1335. Do you pre-grind the flax?

    yes in a coffee grinder
  1336. I love it how my reddit karma keeps going up and down
  1337. all posts have below 70% upvote rate
  1338. :emoji_51:
  1339. everyday life in croatia be like
  1340. I just saw that posted on r/idiotsincars
  1341. Image
  1342. that would never happen here
  1343. it's more an issue that cars stop for you even when they wouldn't have needed to and you awkwardly walk in front of them while they are stopped 😂
  1344. but I'm glad it be this way
  1345. like here the second car already would have stopped and maybe even the first car on a weird day
  1346. it's more an issue that cars stop for you even when they wouldn't have needed to and you awkwardly walk in front of them while they are stopped 😂

    there's a law here that states a cyclist needs to get off the bike when crossing a zebra. but cyclists are not allowed to ride on the pedestrian pavement. so you know how fucked up it is
  1347. it's more an issue that cars stop for you even when they wouldn't have needed to and you awkwardly walk in front of them while they are stopped 😂

    Lol same Sometimes I’ll wait to J-walk and the car will stop even though there’s no intersections or crosswalks lmfao So instead I just have to really slowly walk or pose like I’m not waiting on traffic to cross xdddd
  1348. there is an obvious contradiction in law
  1349. I always get mad inside “like wtf!!! You have the right of what wtf are you doing!!!?!???”
  1350. Lol same Sometimes I’ll wait to J-walk and the car will stop even though there’s no intersections or crosswalks lmfao So instead I just have to really slowly walk or pose like I’m not waiting on traffic to cross xdddd

    it's like you're living in a GTA city
  1351. it's like you're living in a GTA city

    Ya lmao ig
  1352. usually the traffic is fine here but not because of law
  1353. but because the people have unwritten rules they stand by
  1354. mostly respect and logic
  1355. but one fool is enough to throw my mood off for the whole day
  1356. it's mostly Bosnians roflmao
  1357. usually the traffic is fine here but not because of law

    Are you also Croat?
  1358. Are you also Croat?

    yes
  1359. I am VP dude
  1360. it's mostly Bosnians roflmao

    with a heavy accent and no common sense
  1361. okaye gn
  1362. I need to up my glycogen game
  1363. thinking D Ribose high dose
  1364. isomaltulose as well
  1365. pea protein
  1366. if someone has more ideas lemme kno
  1367. I am VP dude

    How many alts you got bruh
  1368. It seems that we are neighbours. I find the interactions between former nations of Yugoslavia intriguing to say the least. So much pride everywhere.
  1369. Is this a whole server of VP arguing with himself with different avatars?
  1370. 😂
  1371. Image
  1372. It seems that we are neighbours. I find the interactions between former nations of Yugoslavia intriguing to say the least. So much pride everywhere.

    I don't have pride about my people, I feel pity if anything. I feel we suffered greatly historically. All of the nations here. Our true cultural identities are stolen. I have pride about where we all come from, pride about this geographical space, it's very special
  1373. what I said about Bosnians and road, they don't understand things in Zagreb don't work according to law. Common sense needs to be applied for everything to work smoothly
  1374. if they spend some time here eventually they realize how things work
  1375. it's not about them, it's about the cultural shock. all minorities are like this it's just that the Bosnians are the most frequent minority
  1376. What ya think VP?
  1377. I found some issue about butyrate supplementation one night when I was overly stoned but forgot about what it was
  1378. BOT

    GG , you just advanced to level 9!
  1379. I found some issue about butyrate supplementation one night when I was overly stoned but forgot about what it was

    I'm interested in butylated hydroxytoluene. Any thought on that?
  1380. BOT

    GG , you just advanced to level 4!
  1381. order 100 of these you won't regret
  1382. nootropic ergogenic tastes like Eden
  1383. I'm interested in butylated hydroxytoluene. Any thought on that?
    Butyrate is an abundant metabolite produced by the gut microbiota and is known to modulate multiple immune system pathways and inflammatory diseases. However, studies of its effects on virus infection of cells are limited and enigmatic. We found that butyrate increases cellular infection and virus replication in influenza virus, reovirus, and hu...
    Image
  1384. something to be considered regarding all dietary interventions
  1385. yes I found it
  1386. Butyrates will cause Epstein Barr reinfection be careful
  1387. Interesting. I was peaked in interest on BHT as it is alleged to supress herpes viruses, and I am swayed by the viral theory of alzheimers (though as a degenerative symptom, rather than the root cause)
  1388. Interesting. I was peaked in interest on BHT as it is alleged to supress herpes viruses, and I am swayed by the viral theory of alzheimers (though as a degenerative symptom, rather than the root cause)

    PubMed
    Pan-histone deacetylase (HDAC) inhibitors, which inhibit 11 HDAC isoforms, are widely used to induce Epstein-Barr virus (EBV) lytic cycle in EBV-associated cancers in vitro and in clinical trials. Here, we hypothesized that inhibition of one or several specific HDAC isoforms by selective HDAC inhibi …
    Image
  1389. the most interesting thing you can use it to chase out the virus and kill it
  1390. I feel like everything I take is making my face look younger by the day but I still have acne problems due to excessive sebum secretion
  1391. does anybody have biohacks against this other than the retinoids
  1392. the most interesting thing you can use it to chase out the virus and kill it

    Image
  1393. I feel like everything I take is making my face look younger by the day but I still have acne problems due to excessive sebum secretion

    Ditching most processed oils from my diet gives me zero facial acne and great skin
  1394. Ditching most processed oils from my diet gives me zero facial acne and great skin

    IG I could try that. I still use olive oil and pumpkin seed oil
  1395. makes the dishes way better
  1396. the prob is I've inherited this sebum secretory skin from my mother
  1397. she still has acne sometimes at nearly 60 yrs old
  1398. I only use a dash of olive oil (Sirtuin activator) and a few caps of NCT with my morning coffee/tea, and some algae oil at night. Other than that, it's Carbs carbs, carbs
  1399. I only use a dash of olive oil (Sirtuin activator) and a few caps of NCT with my morning coffee/tea, and some algae oil at night. Other than that, it's Carbs carbs, carbs

    I think it's key to separate the oils from the carbs
  1400. I notice instant sebum secretion when I consume a meal that's high in both
  1401. I think it's key to separate the oils from the carbs

    Def don't play well together. I love Olive oil, there's a great Grove nearby I need to check out. But at the end of the day, it's just fat :emoji_52~4:
  1402. I'm trying to maximize insulin sensitivity and cut bodyfat
  1403. indeed. omega 9 increases sebum secretion
  1404. I'm trying to maximize insulin sensitivity and cut bodyfat

    use my protocol
  1405. you will cut within days
  1406. use my protocol

    What's your prootocol
  1407. Bro
  1408. What's your prootocol

    u don't know
  1409. omg
  1410. IDK sheet
  1411. there's a lot to be said
  1412. Lay it on me you Croatian MF'er
  1413. Image
  1414. Image
  1415. Image
  1416. Image
  1417. I modified it. omitted the memantine and DHF for optimal neuronal pruning
  1418. 1st day 1200 kcal 40 g protein 2nd-5th day 725 kcal and 30 g protein
  1419. light endurance exercise as much as possible, without strenous activity
  1420. when you refeed don't introduce food in 500 kcal increments per day. do not bring in more at once it will cause hyperglycemia. space out the meals as much as possible in the insulin sensitive window
  1421. which is 9 AM to 2 PM and 3PM to 6 PM
  1422. subL matcha is essential for optimal visceral fat targeted weight loss. also improves fasting tolerance i.e. reduces hunger
  1423. will make you a bit nauseous if you do it food a few hours after you take it tho
  1424. so do it first thing in the morning and around 1 o clock PM
  1425. the original protocol is by Valter Longo I have only build upon it
  1426. he is a true genius no other doctor like him on the planet
  1427. Image
  1428. will play more with the protocol, I think B vitamins may be key here.
  1429. btw the addition of Rapamycin may have caused too much autophagy and apoptosis. I had a headache and muscle pains on day 3 last time I did it. Stimulation followed by weakness, had to take a nap
  1430. subL matcha is essential for optimal visceral fat targeted weight loss. also improves fasting tolerance i.e. reduces hunger

    Would EGCG or Green Tea phytosome have the same effect?
  1431. Would EGCG or Green Tea phytosome have the same effect?

    likely yes, but only with caffeine
  1432. caffeine + EGCG have synergistic anorectic effects
  1433. I usually take with caffeine, such as organic coffee, Fresh green yerba mate, and or guayusa
  1434. nice
  1435. btw don't do this too often. it will be stressful on the psyche first time you do it
  1436. I have a bunch of the green-tea phytomse from science.bio shutdown. I have a bag of Jade leaf matcha, but I try to limit my green tea intake due to flouride concerns
  1437. body and brain literally sense famine incoming
  1438. which is exactly the point of this
  1439. to signal repair and optimization
  1440. I've been doing calorie restriction/IF vegan for years
  1441. Its been a while since I've done a proper 72hr plus fast
  1442. yeah calorie restriction is not as effective in my and Longo's opinion
  1443. Its been a while since I've done a proper 72hr plus fast

    takes 3 days to enter true autophagy.
  1444. I think protein, or more specifically Leucine/methionine restriction is generally superior
  1445. I don't recommend true fasting because it can cause electrolyte imbalances and hypoglycemia followed by the extreme hyperglycemic state when refed
  1446. this can be life threatening
  1447. I don't recommend true fasting because it can cause electrolyte imbalances and hypoglycemia followed by the extreme hyperglycemic state when refed

    I'd like to try for 5 days with NAD+ and senolytics at some point
  1448. your vitals need to be monitored
  1449. Might be a good time to reset my caffeine tilerance
  1450. I'd like to try for 5 days with NAD+ and senolytics at some point

    just try the FMD you will be convinced the benefits are the same, yet the risks are greatly diminished
  1451. there is no reasoning to do a true fast after Longo's work
  1452. Click to see attachment

    You did show me this one before, the FMD cronometer
  1453. it should be a thing of the past now
  1454. light endurance exercise as much as possible, without strenous activity

    Would multiple hour walks suffice for this?
  1455. I don't think humans have ever historically fasted at all, there was always some food to it, but it was limited at times
  1456. Would multiple hour walks suffice for this?

    indeed
  1457. indeed

    That's my antidepressant of choice
  1458. I hadn't watched Longo interview or reviewed much of his literature
  1459. That's my antidepressant of choice

    mine is cycling. my walking parts of the brain have withered away. I even cringe a little when I see people walk roflmao
  1460. mine is cycling. my walking parts of the brain have withered away. I even cringe a little when I see people walk roflmao

    Randomly went on a 6 hour walk the other day
  1461. sometimes I choose to walk to the store
  1462. feels extremely awkward
  1463. like I'm a demon that just took control of a new host
  1464. like I'm a demon that just took control of a new host

    Your alts are starting to make more sense
  1465. Image
  1466. he's not wrong
  1467. but his solution is
  1468. people need to ride bikes
  1469. quite simply. laziness needs to be nooked with chemicals
  1470. Click to see attachment

    Image
  1471. Click to see attachment

    Image
  1472. Amsterdam everywhere please
  1473. The Segway guy was onto something IMO
  1474. Bike speeds in a walking footprint
  1475. Bike speeds in a walking footprint

    wut
  1476. wut

    Image
  1477. BOT

    GG , you just advanced to level 5!
  1478. Great solution for urban mobility, of there was sufficient adoption/infrastructure created with them in mind. However due to the cost and stigma, they remain niche
  1479. Click to see attachment

    ye I know what a segway is. it's less safe compared to a non-electric bike, has a way higher footprint, burns almost no calories at all
  1480. also you look like a dork
  1481. ye I know what a segway is. it's less safe compared to a non-electric bike, has a way higher footprint, burns almost no calories at all

    Wdym by footprint?
  1482. also you look like a dork

    That's the stigma
  1483. Wdym by footprint?

    ecological footprint. it still uses lithium batteries, requires a computer, etc.
  1484. people need to ride bikes

    And cities need to have everything necessary in a few km range
  1485. 🙏
  1486. average lifetime of Segway and electric scooters is abysmal compared to a bicycle. esp if it steel or aluminum
  1487. ecological footprint. it still uses lithium batteries, requires a computer, etc.

    Yup
  1488. I have an aluminum frame now. as soon as I kill it somehow I'm getting a stainless steel bike and keeping it for life
  1489. And cities need to have everything necessary in a few km range

    not really people just need to become stamina beasts they really are again
  1490. takes me 30 mins to cross 10 km easily.
  1491. we are made for bicycles. feet are fucked up. but legs are optimal
  1492. hence we can barely run without getting injured
  1493. but anyone can ride a bike as long as their mitochondrion are functional
  1494. and the best thing is, riding a bike makes the mitochondrion functional
  1495. so it's a self fulfilling prophecy in a way
  1496. I've had an aluminum felt for years. Done many a repairs to keep it chugging. It's a mountain bike frame that I put road tires on, and allows me to lock out the front shocks on road, and I can swap in my offroad tires if I want to hit trails
  1497. blank I read your stylized username like a retarded brit would pronounce the word blunt while spitting saliva in your face
  1498. Sadly I trashed my knee years ago from commuting by bike too much, I think I have a cyst on my left IT band and wayy advanced arthritis for my age
  1499. blank I read your stylized username like a retarded brit would pronounce the word blunt while spitting saliva in your face

    Image
  1500. Sadly I trashed my knee years ago from commuting by bike too much, I think I have a cyst on my left IT band and wayy advanced arthritis for my age

    IDK what's your exact problem with the knees but biking did not cause it
  1501. if you push too hard you can fuck up your knees
  1502. if you do drops you will fuck up your knees
  1503. if your bike is too small you will fuck up your knees
  1504. if your pedals are too close together for your hip size it will fuck up your knees
  1505. if you know how to ride and did a proper bike fit, you will not fuck up your knees
  1506. in fact it will heal your knees
  1507. I had many knee accidents in my life and biking has always improved it and got me back on track
  1508. IDK what's your exact problem with the knees but biking did not cause it

    I was commuting 15 miles per day for years along with recreation riding. I left work and was pedaling hard and felt a pop, never been the same since. Had a bunch of MRI's and x-rays, orthopedic surgeons Saud there wasn't much they could do
  1509. yeah you got humbled I guess
  1510. Told me I'll need a knee replacement, eventually diuble
  1511. However
  1512. I ride at high speeds but never push
  1513. build up the speed slowly
  1514. I yhink I'll try to Find a doc whose willing to do arthroscopy
  1515. And then start on Stem cells and rehab
  1516. have u trialed bpc
  1517. I don't want bionic parts. I wanna fix my OEM
  1518. have u trialed bpc

    I have two Nasal sprays from science.bio, considered injecting
  1519. nasal spray delivery is often suboptimal
  1520. injecting is best
  1521. but be careful. talk to Cogmetics. he has some things against it
  1522. I never had the need to do it so never really researched it well
  1523. I don't want bionic parts. I wanna fix my OEM

    bionic legs though 🤤
  1524. btw I slept like a baby. had a dream in which a random person I know tried to mog me for money with some gang members. I tricked them with word play they left
  1525. 🤣
  1526. btw I slept like a baby. had a dream in which a random person I know tried to mog me for money with some gang members. I tricked them with word play they left

    Busting rhymes on these ninjas
  1527. Busting rhymes on these ninjas

    Monkey Island vibes
  1528. but be careful. talk to Cogmetics. he has some things against it

    Uxkull got depressive symptoms IIRC
  1529. Uxkull got depressive symptoms IIRC

    well not a very trustworthy source on anecdotals kek
  1530. but there's more. Cog knows more
  1531. would u like to introduce this emoji. I can edit it for the transparent bg
    Image
  1532. BOT

    GG , you just advanced to level 10!
  1533. Image
  1534. fuck I need this sticker on my bike
  1535. suspicious
  1536. suspicious

    u have too much oxytocin bruh
  1537. u have too much oxytocin bruh

    I used to be really autistic though
  1538. there is no place, do you have GIF emojis?
  1539. :emoji_49:
  1540. it really explains a lot about shizotypal minds considering the effects of oxytocin on outgroup aggression
  1541. this emoji is duplicated
  1542. and discord has it's own flag emojis so they could just be removed
  1543. 🔪
  1544. :emoji_49:

    I forget to stole this
  1545. :emoji_21: 🔥
  1546. 2 different fire emojis too 😩
  1547. Pepe is the best
  1548. and discord has it's own flag emojis so they could just be removed

    That's Unicode 9.0 before google start getting crazy
  1549. toad men mascot
  1550. They just seek novelty
  1551. I wanted Murray to mock annoying users
  1552. Image
  1553. this one is better for that purpose
  1554. :emoji_51~1: :emoji_40: :emoji_40:
  1555. Monkey Island Wiki
    "... and the forces of darkness will applaud me as I STRIDE through the gates of hell carrying your head on a pike!" ―Murray Murray is a Demonic Skull that terrorized Guybrush Threepwood who first appeared the Curse of Monkey Island. He was originally part of LeChuck's Army of the Undead, before losing his entire skeletal body, and becoming some...
    Murray
  1556. :emoji_51~2:
  1557. BOT

    GG , you just advanced to level 3!
  1558. if the user knows the context it's even more effective
  1559. finally some contribution from r/Nootropics
  1560. btw dudes and dudettes. if anyone has COVID anosmia let me know
  1561. I managed to fully recover from mine
  1562. I am still mesmerized by the fasoracetam ADHD study
  1563. the no adverse effect thing is most amazing
  1564. it appears we only need to make it cheaper
  1565. what the subjective effect was exctly
  1566. what the subjective effect was exctly

    never tried it, most users report anxiolysis, relaxed mood
  1567. most users is actually just a few people
  1568. no one knew about this until they talked to me
  1569. everyone thought 50 mg dose does something before I stepped on deck
  1570. What's the function of  metabotropic glutamate receptors
  1571. What's the function of  metabotropic glutamate receptors

    pfft there's 7 of them
  1572. no one knew about this until they talked to me

    I take it, I give full report
  1573. I take it, I give full report

    yeah but how much
  1574. they are involved in learning, memory, anxiety, and the perception of pain
  1575. yeah but how much

    If I take it
  1576. they are involved in learning, memory, anxiety, and the perception of pain

    Wikipage
  1577. they are involved in learning, memory, anxiety, and the perception of pain

    indeed
  1578. See there relation
  1579. See there relation
    PubMed Central (PMC)
    Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms associated with schizophrenia. mGluR5 plays an important role in both long term ...
    Image
  1580. :emoji_21:
  1581. faso means fire
  1582. it block learned hopelessness
  1583. biotune - the nature develop her self.. by human explorations.
    what is antidepressant and how it's work and what receptors act on with full details
    receptors function database
  1584. mGluRs are many. they have many functions. we can get a load of effects modulating these
  1585. Glutamate is a library
  1586. the receptor heteromers only make this more true
  1587. Look at these
  1588. Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application. An interesting side effec...
    Proglumide
  1589. There a protein that cause your PFC to detect triggers, some people have upregulation in it causing them to be highly reapornsive to placebo/CBT/sensitive to feel rewards, this type of thing inculding placebo in reality not something that not exist , it is product geniunly real effect
  1590. ur golden
  1591. I see u upgraded this from the last time I seen it
  1592. I see u upgraded this from the last time I seen it

    There new superior version
  1593. Still not uploaded
  1594. nice
  1595. lmk
  1596. I'm trying to make it just show one receptor par time
  1597. When I see it I read it like news paper
  1598. But other people have a hard time lol
  1599. AMPA respect++
  1600. other people have cognitive dysfunction or low IQ
  1601. or just illiterate
  1602. obv there are many more things to add here
  1603. references above all
  1604. Reference is available click on small point in the cell
  1605. Reference is available click on small point in the cell

    nice didn't notice that
  1606. I wouldn't use wiki as reference tho
  1607. too unreliable
  1608. other people have cognitive dysfunction or low IQ

    I think its due to practice the data a lot , so AMPA duplicated neuron pathway used
  1609. so many things are wrong on wiki, they have broken references, they delete things often
  1610. I think its due to practice the data a lot , so AMPA duplicated neuron pathway used

    yeah data spreadsheet illiterate that's what I meant
  1611. so many people can't even read a simple graph and it's 2022 such a shame and disgrace to humanity
  1612. Google blocked my blog last week
  1613. Due I made a article named , stop lifying please
  1614. 😂
  1615. 🥊
  1616. we'll fight dem
  1617. we need powe
  1618. renamed the article and Contacted them , about that article about nature tell humanity this
  1619. They opens it again
  1620. This will keep you from pissing clear every 2 minutes
  1621. This will keep you from pissing clear every 2 minutes

    actually it has a diuretic effect until I develop tolerance. this seems to correlate with the negative mood effects
  1622. actually it has a diuretic effect until I develop tolerance. this seems to correlate with the negative mood effects

    Do you develop "tolerance" to anything else besides the endocrine vasopressin effect
  1623. Do you develop "tolerance" to anything else besides the endocrine vasopressin effect

    it appears not. this sucks because my regimen calls for cycling of citicoline one week on one week off. this brings the tolerance back to normal which is bad because it means I'll be fucked up for half of the week
  1624. I cycle it because of TMAO bacteria die off
  1625. I cycle it because of TMAO bacteria die off

    Could you wage a perpetual war with some kind of probiotic?
  1626. Also wait you're saying having elevated antidiuretic hormone has a diuretic effect?
  1627. Could you wage a perpetual war with some kind of probiotic?

    there is too litle info on this sadly. microbiome is largely a mystery. What we do know is that in absence of dietary choline and carnitine these bacteria die off or change their metabolic preferences as shown by the reduced TMAO levels in vegetarians. upon introduction of choline after a week they had the same TMAO levels as omnis
  1628. Also wait you're saying having elevated antidiuretic hormone has a diuretic effect?

    this is because of the MoA of release.
  1629. choline is diuretic itself and the effect appears stronger than the vasopressin release it causes
  1630. so it's not that the elevated vasopressin causes a diuretic effect, it's just that CDP choline has a diuretic effect DESPITE the vasopressin release
  1631. btw look into the cholinergic syndrome prophylaxis
  1632. choline is diuretic itself and the effect appears stronger than the vasopressin release it causes

    ok ok so it's this you're developing tolerance to?
  1633. aCh is a potent secretagogue of everything that comes out of the human body
  1634. ok ok so it's this you're developing tolerance to?

    yes after about 3 days my pissing habits are back to normal
  1635. depending on the rest of the supplementation, hydration and diet ofc
  1636. the negative mood effects are also gone after 3 days
  1637. I can tolerate people again :emoji_48:
  1638. it's not like I ever like them tho
  1639. Isn't colinagic is depressive due to muscarine receptors antagonists being drug of abuse
  1640. And produce euphoria
  1641. I'm longterm user of tehyrexphynodyle
  1642. its ultimately develop tolerance where you need to take it once every 23 days to works
  1643. it's multimodal probably.
  1644. And tolerance develop for euphoria but not for cognitive decline
  1645. So if you analyzed this exp in opposite way
  1646. Then agonists will enhance cognition and decrease mood
  1647. But evenatly you will get just enchantment in cognition
  1648. I think muscarinic activation prevents you to unsee the bad aspects of your own life. So the cognition improving aspect and the decrease in mood is the same thing
  1649. but after a while it is easier to tolerate the negative affect
  1650. Yeah I thinged about that
  1651. I'm longterm user of tehyrexphynodyle

    what is this
  1652. It might control neuron that its job is transmittion of bad memory
  1653. yes rumination is exceptionally easy when muscarinic receptors are activated, but more than anything, it is easier to recognize bad intentions of other people which generates a negative worldview quickly
  1654. if everyone around you is ill-intended your life cannot be good logically
  1655. but these are not schizotypal semidelusions, they're realistic examinations of other people
  1656. look at wiki page of negative affect
  1657. The same problem in memoriesing by M1-5 and understanding of D2
  1658. people with high negative affect are nearly immune to deception
  1659. Both decrease mood
  1660. In way or other
  1661. also people with negative affect are less likely to discriminate against other races for example
  1662. people with high negative affect are nearly immune to deception

    Nice
  1663. so in my opinion high negative affect is optimal
  1664. but an optimistic worldview needs to be maintained
  1665. because this is correlated to overall life success
  1666. problem is that these two are negatively correlated
  1667. so we need to break the correlation between negative affect and pessimism somehow
  1668. you are thinking like I does
  1669. Thinking after the point where other people stop
  1670. we're gonna burn the world and grow a new one
  1671. so we need to break the correlation between negative affect and pessimism somehow

    I almost did the samething for daltafos b
  1672. Eventually found he relay on nmda association to know what drugs caused euphoria
  1673. I almost did the samething for daltafos b

    my expression is probably very high
  1674. I'm addicted to cycling
  1675. Then he start unfair selective agreement generation advocate drug use
  1676. Block nmda and your unawareness can't know THC sigarrt is the cause
  1677. I believe the evolutionary usecase of delta fos B is to stimulate locomotor activity and make it hurtful for the organisms to stay still for too long
  1678. No drug cue
  1679. yes I recovered from THC addiction with memantine
  1680. but it did not decrease propensity for exercise
  1681. I believe the evolutionary usecase of delta fos B is to stimulate locomotor activity and make it hurtful for the organisms to stay still for too long

    I found dalta fos be help me in getting addicted to coding
  1682. It make it less anxious and more pleasurable by decreasing aversion and doing rewards sensitization
  1683. Almost year and half ago I made experiment on codiene
  1684. Took 2 doses 120mg
  1685. of amph?
  1686. Then waited to see how much craving need to faded
  1687. oh codeine
  1688. I found that I needed 4 months to forget how opiates look like
  1689. I thought you meant coding 😛
  1690. opiates cause no behavioral sensitization for me
  1691. they cause negative mood states
  1692. With a half life like this , daily intake will accumulate craving to point having enough dominance to change your opinion
  1693. they cause negative mood states

    What's is this opiate
  1694. dysphoria with a large decrement in attention and overall cognition
  1695. but I tried heroin only
  1696. People who took hero always not like it first time
  1697. Don't try it again
  1698. I won't it was an accident
  1699. microdosing codeiene and multi substance formula I talked about was not addictive
  1700. thought it was just cannabis
  1701. I took 7.5mg /d for 2 month
  1702. blocked depandance in silent phrase by topiramat
  1703. blocked depandance in silent phrase by topiramat

    never knew about that drug it's amazing
  1704. Image
  1705. I'm trying to find the study
  1706. Anyway
  1707. Its ampa antagonist
  1708. Aftee you stop opiates there 3 days
  1709. Where opiates in not in your system but you still did not get withdrewal
  1710. Its called sielnt phrase
  1711. In this phrase amap work I'm encoding level which we don't know shit about
  1712. To prepare need for withdrawnl execution (some types of depandance not all)
  1713. Then their job end and signal transfired to nmda who will execute it
  1714. Blocking ampa in sielnt phrase block withdrewall symptoms
  1715. Or you will need long term usage of nmda antagonist (21days) for switching bad emotions off
  1716. 21 due to median need practice for humans to gain habit is 21days
  1717. Which depende on nmda and habit not always being good and not always awerness mediated, its just sometype of plasticity
  1718. This type of research called biotuning and there group of people like biohackers for it
  1719. biotuners
  1720. more accurate compared to biohackers
  1721. They analyze things in biological manner without using computional neuroscience, which will cause you to not understand anything lol
  1722. behavioral experiments?
  1723. Mean what
  1724. ?
  1725. Don't mention CBT
  1726. I mean take one substance which is a known agonist of some receptor, take another substance, if it potentiates effect it's a PAM, if it has additive effects it's another agonist and if it cancels effect it's either an inverse agonist or antagonist
  1727. for example
  1728. Need a lot of cycling time
  1729. obviously these experiments are confounded by many things such as enzymatic interaction, indirect receptor activity, etc.
  1730. unrelated activities may produce similar behavioral effects as well
  1731. mmm yeah pregabaline opiates
  1732. mmm yeah pregabaline opiates

    IMO these studies are mostly sufficient after thorough in vitro binding activity testing
  1733. but there are always unknown or untested receptors, enzymes, transporters, even modulation of gene expression
  1734. do you have ideas for safety testing without animals?
  1735. do you have ideas for safety testing without animals?

    Supercomputing/AI until full-brain/full-organism in silico modeling
  1736. It can happen
  1737. It can happen

    Can happen is not enough for it to happen tho'
  1738. everything that can go wrong will go wrong eventually
  1739. but everything that can go right will rarely go right without intervention
  1740. Maybe biohack to get superhuman regeneration ability so we can give ourselves organ failure etc. and just replace it
  1741. BOT

    GG , you just advanced to level 2!
  1742. do you have ideas for safety testing without animals?

    Taking D3 antagonist and willing to not increase dose more then 25% par day
  1743. Maybe biohack to get superhuman regeneration ability so we can give ourselves organ failure etc. and just replace it

    if I was the other sex I would be hot and moist listening to your fantasies
  1744. PubMed
    The expression of IL-1 is elevated in the CNS in diverse neurodegenerative disorders, including Alzheimer's disease. The hypothesis was tested that IL-1 beta renders neurons vulnerable to degeneration by interfering with BDNF-induced neuroprotection. In trophic support-deprived neurons, IL-1 beta co …
    Image
  1745. BOT

    GG , you just advanced to level 11!
  1746. interleukinss have the most annoyingly complex interaction with everything
  1747. even tissue selective modulation is largely unusable becuse of this
  1748. we need time selective modulation for the whole inflammasome it seems however this would require a higher understanding of biomarkers we can use to see if inflammation is necessary at all
  1749. i.e. in infection, injury, etc.
  1750. :notetake:
  1751. BOT

    GG , you just advanced to level 2!
  1752. I’m actually not able to find a study on oxytocin levels in autist’s cerebral spinal fluid -they’ve all stuck to testing blood/serum levels. Honestly it never made sense that oxytocin would be low in autists considering oxytocin promotes a slow life history strategist phenotype -and that autism (imo) seems to be an exemplary slow life history strategist phenotype. But I could be wrong about autism == slow life history strategist phenotype -I’ve heard claims of the contrary. Also autism and schizophrenia share a lot of similarities, having even been considered the same disorder at one point too.
  1753. do you have ideas for safety testing without animals?

    Homeless people 👍
  1754. I feel superhuman
  1755. people on the internet are constantly telling me what I'm doing is impossible
  1756. maybe internet people are just pussies tho'
  1757. delta males getting mad about other man's modest success
  1758. Congrats :emoji_52:
  1759. Congrats :emoji_52:

    thanks? :emoji_1:
  1760. Click to see attachment

    3 different sneeds? Part bird for sure
  1761. Thinking about basically replacing milch with lentil soup, kale, and calcium carbonate, but I think I can count on one hand the amount of times I've had legumes or leafy greens in my life 💀
  1762. That's so much iron, manganese, and folate dawg
    Image
  1763. I need some deferoxamine
  1764. Buy it?
  1765. I think 50mg would be good dose
  1766. I'll add it to the potato water
  1767. I am still mesmerized by the fasoracetam ADHD study

    Something I should look into? I'd like non-stim options for ADD
  1768. Message could not be loaded.

    I've been wondering about this, as I take 600mg of ALCAR and 85mg of citicoline most days. I tend to combine with PQQ, resverateol and a teaspoon of EVOO to hopefully mitigate TMAO conversion, and itherwise eat a high fiber plant-based diet, But I wonder what else can be done to inhibit TMAO and the pathogenic bacteria that produce it
  1769. maybe internet people are just pussies tho'

    Tbh :/
  1770. Something I should look into? I'd like non-stim options for ADD

    yes you should look into it. but before trying it get gene testing. it's too expensive to be a hit or miss.
  1771. I've been wondering about this, as I take 600mg of ALCAR and 85mg of citicoline most days. I tend to combine with PQQ, resverateol and a teaspoon of EVOO to hopefully mitigate TMAO conversion, and itherwise eat a high fiber plant-based diet, But I wonder what else can be done to inhibit TMAO and the pathogenic bacteria that produce it

    dudeee u dropped the L to lowercase. AICAR is another substance.
  1772. yes you should look into it. but before trying it get gene testing. it's too expensive to be a hit or miss.

    TL;DR on the genes in question? I've already been tested
  1773. you won't get any TMAO from that stack
  1774. TL;DR on the genes in question? I've already been tested
  1775. look at study for reference
  1776. Image
  1777. Click to see attachment

    epilepsy alert
  1778. look at my DM plsss
  1779. oh whoops ya
  1780. look at my DM plsss

    Oh right!!!!!@!!!!!!
  1781. Thotties
  1782. twoad
    Image
  1783. Click to see attachment

  1784. amen break soothes ones soul:emoji_51~1:
  1785. amen break soothes ones soul:emoji_51~1:

    it rly does
  1786. this hits diff tho
  1787. Click to see attachment

    I've been assuming you're Gvanebrain on the reddit?
  1788. He's selling spiral energy from Gurren Lagann
  1789. He already sells pregnenolone and calls it 'the real red pill'
  1790. I've been assuming you're Gvanebrain on the reddit?

    yes
  1791. He's selling spiral energy from Gurren Lagann

    his supplements have no merit. but his infomercials are perfect mixtape food.
  1792. Shadowbanned video
  1793. I've been assuming you're Gvanebrain on the reddit?
  1794. read my write up
  1795. join the subreddit ur even vegan
  1796. Alex Jones is sadly a fraud but this is so entertaining to listen to
  1797. Alex Jones is sadly a fraud but this is so entertaining to listen to

    I will be the next Alex Jones but with real supplements :emoji_50~1:
  1798. plot twist: keeping the tomes for myself. I'll be the smartest person on the planet
  1799. I thought vegans were supposed to be anemic lol
  1800. EZ
  1801. I thought vegans were supposed to be anemic lol

    yeah I'm near anemic despite more than 50 mg dietary iron daily
  1802. I consider this a good thing
  1803. But how
  1804. stupid doc told me I'm prolly depressed because of this
  1805. Oh yeah heme exists
  1806. took high dose D3 and rested for a while the bad mood went away
  1807. still near anemic
  1808. is this off blood tests
  1809. BOT

    GG , you just advanced to level 3!
  1810. is this off blood tests

    yes
  1811. So proud
  1812. So proud

    vegan diet is naturally full of iron chelators
  1813. i.e. polyphenols
  1814. Need to get my plant compund knowledge up 💯 like you
  1815. Need to get my plant compund knowledge up 💯 like you

    that's what she said
  1816. PubMed Central (PMC)
    Working memory is a form of short-term memory that involves maintaining and updating task-relevant information toward goal-directed pursuits. Classical models posit persistent activity in prefrontal cortex (PFC) as a primary neural correlate, but emerging ...
    Image
  1817. vegan diet is naturally full of iron chelators

    I've been taking Primavie Shilajit, which I suspect helps protect from anemia
  1818. But IMO borderline insufficient iron stores are superior to excess iron, by a long shot
  1819. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor.
    PubMed Central (PMC)
    GPR12 is a G protein-coupled orphan receptor genetically related to type 1 and type 2 cannabinoid receptors (CB[1] and CB[2] ) which are ancient proteins expressed all over the body. Both cannabinoid receptors, but especially CB[1] , are involved in ...
    Image
  1820. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor.

    God knows it's still an orphan recrptor
  1821. Endogenous ligands are in the grey area
  1822. CBD is an inverse agonist
  1823. Some neuropeptide is an agonist
  1824. Nesfatin-1
  1825. The receptor is related to LPA
  1826. MCR
  1827. God knows it's still an orphan recrptor

    Oh fair lol, I retracted closely from related
  1828. Nah it's related to cannabinoid receptors by homology
  1829. MCR too
  1830. All I know is that it's a very promising target for cognition
  1831. MCR too

    That is interesting
  1832. Well working memory aspect specifically
  1833. I gotta find an evolutionary tree of g coupled protein receptors evolution
  1834. A hierarchical taxonomy of how they all diverged
  1835. Probably would reveal a lot
  1836. I'm gonna look into more gpcrs and orphan receptors for cognition
  1837. BOT

    GG , you just advanced to level 1!
  1838. :D
  1839. GPR139 is interesting
  1840. How it antagonizes MOR and is co-expressed with D2
  1841. I'm gonna look into more gpcrs and orphan receptors for cognition

    Novel targets are cool cause we might accidentally find a new way to get high if we’re lucky loool
  1842. But IMO borderline insufficient iron stores are superior to excess iron, by a long shot

    indeed, less oxidation, esp in dopaminergic neurons which is important for Parkinson's prevention
  1843. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor.

  1844. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor.

    God knows it's still an orphan recrptor
  1845. Endogenous ligands are in the grey area
  1846. CBD is an inverse agonist
  1847. Some neuropeptide is an agonist
  1848. Nesfatin-1
  1849. The receptor is related to LPA
  1850. MCR
  1851. God knows it's still an orphan recrptor

    Oh fair lol, I retracted closely from related
  1852. Nah it's related to cannabinoid receptors by homology
  1853. MCR too
  1854. All I know is that it's a very promising target for cognition
  1855. MCR too

    That is interesting
  1856. Well working memory aspect specifically
  1857. I gotta find an evolutionary tree of g coupled protein receptors evolution
  1858. A hierarchical taxonomy of how they all diverged
  1859. Probably would reveal a lot
  1860. I'm gonna look into more gpcrs and orphan receptors for cognition
  1861. BOT

    GG , you just advanced to level 1!
  1862. :D
  1863. GPR139 is interesting
  1864. How it antagonizes MOR and is co-expressed with D2
  1865. I'm gonna look into more gpcrs and orphan receptors for cognition

    Novel targets are cool cause we might accidentally find a new way to get high if we’re lucky loool
  1866. But IMO borderline insufficient iron stores are superior to excess iron, by a long shot

    indeed, less oxidation, esp in dopaminergic neurons which is important for Parkinson's prevention
  1867. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor.

  1868. indeed, less oxidation, esp in dopaminergic neurons which is important for Parkinson's prevention

    I think excess iron is also involved in lipofuscin and amyloid plaques.
  1869. Novel targets are cool cause we might accidentally find a new way to get high if we’re lucky loool

    I did find a new way to get high but I can't disclose it because the community is a shithole stealing novel substances to make money. Whoever doesn't steal likes talking and it eventually ends up with Sirsad
  1870. I won't be a psychedelic Nikola Tesla. My fate is to be crowned as the toad king
  1871. Image
  1872. I won't be a psychedelic Nikola Tesla. My fate is to be crowned as the toad king

    Image
  1873. Click to see attachment

    Funny thing I had a CEV the other day of a unicorn prince fetus. He was pretty, shiny and cute
  1874. gotta make it with MJ
  1875. hi
  1876. is this a nootropic server? i joined from a random invite
  1877. is this a nootropic server? i joined from a random invite

    advanced biohacking
  1878. mostly cognitive enhancement but also longevity
  1879. cool
  1880. time for 30 mg memantine
  1881. ohh not today
  1882. tomorrow
  1883. lol
  1884. let me finish at least
  1885. let me finish at least

    watch your step
  1886. it is your decision, but if you idea is to learn
  1887. is to enhance learning
  1888. you are missing the %50 of the stuff
  1889. Original message was deleted.

    this is the %50 of the job
  1890. I said what I said. You acting like you know me for the past 10 years and have been studying beside me makes you look dumb and rude. Don't hmu until you change yourself again
  1891. whatever
  1892. Image
  1893. take care, predators out there.
  1894. i really expected snorting modafinil to hurt
  1895. i was wrong
  1896. i really expected snorting modafinil to hurt

    armoda?
  1897. regular moda
  1898. w fillers
  1899. Image
  1900. presumably
  1901. toad king checking in. mossy branch cozy
  1902. moissst
  1903. w fillers

    pleb shit
  1904. ill have you know the indians are very competent
  1905. obv
  1906. the prob is that you buy pills not powders
  1907. has emi teached you nothing
  1908. where you gonna get modafinil powder
  1909. i have thousands of $ of powders
  1910. and no pills except this sort of shit
  1911. where you gonna get modafinil powder

    I have pure armoda :emoji_51~1:
  1912. ok well wheres mine
  1913. i have fladra powder
  1914. where the plug at yyooo
  1915. NAC kills moda just like it does amps and phenidates\
  1916. hopefully enough time between
  1917. NAC has abysmal half life
  1918. i posted more shit in my noot channel today than in 2 months
  1919. NAC has abysmal half life

    yea
  1920. i posted more shit in my noot channel today than in 2 months

    obv
  1921. i also started learning algebra 2 to increase grey matter
  1922. Moda is next gen caffeine
  1923. i just now took it
  1924. i take it every work day
  1925. caffeine propelled humanity to industrial revolution, moda is about to propell humanity to become a new species
  1926. im just inducing a hypomanic strreak
  1927. hypomania is not even a thing
  1928. i must stay up 5 days 🙂
  1929. or else ill panic
  1930. jail in 6 days v possible
  1931. now that's where you made the mistake
  1932. i have to make the most of my time
  1933. I sleep erry day
  1934. 8 hours
  1935. i do too
  1936. this is extenuating circumstances
  1937. btw almost subL'd 150 mg DHF
  1938. kek
  1939. want me to follow
  1940. didn't even look at the scale
  1941. i eyeball errything lol
  1942. I did scale it in the last sec before it entered my mouth
  1943. once youve weighed everytthing you take out for 2 years
  1944. no point anymore unless your dumb
  1945. well I don't trust my judgement
  1946. tho' it is very accurate
  1947. this time didn't even think about the amount
  1948. I'm pretty sure nothing bad would happen anyways
  1949. meh its anti hypertensive anyways
  1950. whats worsdt case
  1951. oh kay moda is kicking in
  1952. intruiging
  1953. much head warmth from insuff
  1954. well i gotta get back to research
  1955. ttyl
  1956. you can see whatever i find in my serber
  1957. you can see whatever i find in my serber

    will talk to you tomorrow
  1958. is it a dihexa day?
  1959. its always a risk but this game is risky
  1960. is it a dihexa day?

    What’s your usually day after you take something like Dihexa
  1961. well, if it goes well cognition increases a lot
  1962. is it a dihexa day?

    it's never an exogenous oligopeptide day
  1963. if it doesnt, iget bad brain fog
  1964. I would like play different sports all day
  1965. the more i use it the worse brainfog
  1966. but its been 4.5 months since i dosed it
  1967. and that was 5 doses in 3 days
  1968. the more i use it the worse brainfog

    Makes sense considering what it does
  1969. DIHEXA is retarded
  1970. question is
  1971. is my current state one that would benefit from it
  1972. even endogenous BDNF is retarded most times
  1973. elucidate me as to when dihexa would be optimal
  1974. NO BIASES
  1975. and no cancer propoganda!
  1976. when intraneuron chloride concentration is very low
  1977. same as BDNF
  1978. hmmmmm
  1979. exercise stimulated BDNF releases chloride
  1980. drug stimulated BDNF usually does the opposite
  1981. I would guess DIHEXA does what BDNF secretagogues do to an extreme level
  1982. im probably about to do retarded
  1983. lemme flip a coin
  1984. even endogenous BDNF is retarded most times

    Ngl you’re right I realized this recently
  1985. I took too much DHF
  1986. lol
  1987. welp
  1988. I have to go push the pedal for 10 hrs straight now
  1989. i took a 4 dma 78 dhf when you dosed
  1990. I got bored of using DHF
  1991. its best acutely
  1992. I realized that
  1993. BOT

    GG , you just advanced to level 1!
  1994. daily sucks for me
  1995. Leaf lemme ask you
  1996. I was taking it daily for a week before I realized
  1997. r u capable of DJing
  1998. Then did a cycle of Polygala after
  1999. r u capable of DJing

    only if your tripping
  2000. I was thinking
  2001. we could increase group cohesion if we had a radio channel
  2002. yea we need one
  2003. i mean i can play my stuff
  2004. but i cant guarantee it will be optimal
  2005. u play your breakcore. I trust you not to break my heart
  2006. oh ik
  2007. just play savant
  2008. all autists love savant
  2009. ive been on a white person music meme lately tho
  2010. I'll spin ambient
  2011. choose your weapon
  2012. youd play elevator music
  2013. and like it
  2014. classical psychedelic ambient
  2015. ima play whats it called
  2016. makes me think of blimps
  2017. welpi cant remember
  2018. so id play dirty heads, kanye and watsky
  2019. it's hard to find music that imbues emotion yet doesn't trigger autistic misophonia
  2020. Image
  2021. i hated music most of my life
  2022. Image
  2023. it just
  2024. was boring or too many bpm
  2025. always think of these objects when I say this word
  2026. i want that soup now you fucker
  2027. ima murder you in my sleep
  2028. me too
  2029. but I don't have time for cooking
  2030. I have to push pedals
  2031. or else I will become retarded soon
  2032. today is the day
  2033. BOT

    GG , you just advanced to level 8!
  2034. i think
  2035. yea bot agrees
  2036. yea bot agrees

    no
  2037. p sure the hottest girl at work is working today
  2038. stop with the superstition
  2039. it will KILL YA
  2040. time to get a number
  2041. oh trust me, im way better at killing myself than superstition is
  2042. alcohol is anti superstition
  2043. and im an alcy
  2044. time to get a number

    remember to lean against the wall, tilt your head, take a deep breath, sigh and squint your eyes before you say anything
  2045. thats
  2046. wel its a new one
  2047. i mean she always tries to talk to me
  2048. p sure its in the bag, along w schrodingers cat (i catnapped it)
  2049. catnipped?
  2050. i stole his cat
  2051. it's kinda rude
  2052. should have at least bribed it with catnip
  2053. HE WAS KILLING IT
  2054. yay I have a first reddit follower
  2055. Ok this is what happens when autism begets autism begets autism
  2056. reddit is weird
  2057. i have the best drug potentiation guide on reddit kekek
  2058. I have a feeling all of the users are obese and easy to trigger
  2059. i have the best drug potentiation guide on reddit kekek

    link twink
  2060. old
  2061. and no sources kek
  2062. also missing shit as of now
  2063. i could double the length now
  2064. no homo
  2065. some homo?
  2066. some homo?

    boss
  2067. nah im just an employee
  2068. the psychedelic aspect is prob most focused on in that guide
  2069. i need take quercetinnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn
  2070. cognitively dysfunctional ideas
  2071. I can see why you're fucked
  2072. oh definitely
  2073. thats just the start
  2074. nah im just an employee

    I'm the boss
  2075. half of those ideas prolly kill a lot of braincells
  2076. all the psych potentiation does
  2077. farily sure
  2078. yes
  2079. BOT

    GG , you just advanced to level 12!
  2080. also: benzo potentiation
  2081. however, i have proven noopept potentiates lsd 3x w my free mice
  2082. they tilted their heads at a 3 times higher angle
  2083. black humor is how slavs deal with emotional distress
  2084. thats racist
  2085. should say dark humor
  2086. your just negging them at this point
  2087. if rapamycin wasnt hypertensive i prob would have snorted it all already
  2088. theres a 33% chance dihexa works great if i take today
  2089. 66% it causes brainfog
  2090. 1% chance i die
  2091. hmmmm
  2092. tis a thonker for certain
  2093. wheres my muse, i need inspiration
  2094. "Therapeutic sleep deprivation (SD) is a rapid acting treatment for major depressive disorder (MDD). Within hours, SD leads to a dramatic decrease in depressive symptoms in 50–60% of patients with MDD."
  2095. ok well wheres mine

    See this adrafinil is insanely cheap there online vendors meta search engine: https://nootropicsindex.com/
    Find out where you can buy nootropics. Compare prices for all vendors worldwide. Filter by type: capsules, powder or solution. Sort products by price per gram, price per capsule or product price. Show listed products based on their content and weight.
  2096. Di you have better price?
  2097. adrafinil is shit tho
  2098. even fladra is p shit
  2099. i havent tried armoda
  2100. but only moda is based for me so far
  2101. Do you have better price for any of them
  2102. Like dirty cheap
  2103. i havent tried armoda

    Armoda is the based part of racemic Moda. You can expect double potency
  2104. steal it from indians
  2105. i could double the length now

    do it :emoji_49:
  2106. PubMed Central (PMC)
    MC159 is a viral FLIP (FLICE inhibitory protein) encoded by the molluscum contagiosum virus (MCV) enabling MCV to evade antiviral immunity and to establish persistent infections in humans. Here, we show that MC159 contains a functional SH3 binding motif, ...
    Image
  2107. My "benign" viral infection
  2108. Your gonna tell me a virus is benign if it impairs ability for autophagy?
  2109. If I continue to have it it will almost certainly shorten lifespan
  2110. This is why rapamycin is the cure tho
  2111. oh hey rapamycin fixes that 🙂
  2112. @everyone This backup server invite https://discord.gg/Ahx3kVsp69 Join it, It just backup users you can't read/write or get notified from it.
    You sent an invite to join a server

    animated

    2 Online
    8 Members
  2113. i uhhhh, likely found a cure to an incurable virus
  2114. i just got lucky
  2115. the autophagy inhbition from molluscum is reveresed by rapamycin
  2116. BOOM
  2117. the science is in my server and the mouse is me lol
  2118. but also just fasting for a month should cure it
  2119. i admit the science is still weak
  2120. but theres enough connections for it to be a trialable hypothesis
  2121. if any researchers actually gave 2 shits
  2122. why do you think i dont own my own server
  2123. its a precaution
  2124. Stop misleading members
  2125. BOT

    GG , you just advanced to level 12!
  2126. Image
  2127. uhm
  2128. i developed the ability to type eyes closed overnight
  2129. what the actual fuck
  2130. The attention deficit if was a human
  2131. take risperidone +_+
  2132. you first
  2133. and take mine too babe
  2134. Doing x10 hard work to increase task quality from 95% to 99% will destroy your life
  2135. I don't afaik
  2136. you might just addicted to baseline
  2137. dalta fos b can close your eyes
  2138. Happen to me
  2139. Just try things even if you thing they are useless
  2140. It will lead to a lot of discoveries
  2141. BTW does modafinil halped you
  2142. What's the substances that can suck dick of coffee for you
  2143. I hate baseline
  2144. I love moda
  2145. I hate amphetamine
  2146. Yeah amp induce psychosis
  2147. Also just terrible for health
  2148. beta blocker and you eliminated the heart side effect of it
  2149. Tested before and works
  2150. Between you lost some rewards due to blockage of beta
  2151. Yea yea but I'd rather profit off the amp
  2152. Theoretically
  2153. Cycling meds was not effective for me , I ended using 10 and everyone of them started to work once every month
  2154. Now I seek new receptors to fuck with
  2155. Found that a lot of emotions like optamistic is controled by widely unknown receptors
  2156. I'm reward travaler
  2157. do you have private emoji pack to rob
  2158. Controlling servers from a phone is awsome BTW!!
  2159. finally
  2160. Oh I see, sirsad is here but not my server
  2161. raises fist
  2162. develop some plasticity from reading channels here, you would feel a stranger in first
  2163. Oh I see, sirsad is here but not my server

    just act like its yours, in good way
  2164. I'm taking piracetam rn
  2165. Btw, 44 g piracetam in 2 days is too much
  2166. Just a heads up
  2167. I always imagine suboxone delivery when I see subs-delivery
  2168. I invited you to sirsad server and other one, they are one of the best biohacking servers here
  2169. Invite me too
  2170. To sirs
  2171. Btw, 44 g piracetam in 2 days is too much

    When was the first time you took it
  2172. 4 years ago
  2173. Invite me too

    Sirsad depandanat
  2174. Did he banned you
  2175. No I lefted
  2176. A few weeks agos
  2177. I invited you to one
  2178. Wait
  2179. Wronk one
  2180. But I'm upset w gintrux for not inviting me to that one
  2181. take lamotrigin to not feel such emotions
  2182. I have chemical solution for everything :emoji_49~1:
  2183. i developed the ability to type eyes closed overnight

    unimpressive tbh
  2184. learned this at 9 yrs old or so
  2185. however word count is hard to get up for me
  2186. But I'm upset w gintrux for not inviting me to that one

    nothing lost no opportunity of gain lost either
  2187. unimpressive tbh

    I was retarded at 9 and only passed typing class bc no teacher is gonna fail someone for typing class lmao
  2188. It's a dramatic increase for me to gain that ability at random
  2189. I was retarded at 9 and only passed typing class bc no teacher is gonna fail someone for typing class lmao

    we had no typing class I was just geekin my whole life
  2190. I'm not even human
  2191. I did find a new way to get high but I can't disclose it because the community is a shithole stealing novel substances to make money. Whoever doesn't steal likes talking and it eventually ends up with Sirsad

    :(
  2192. who care for being credited
  2193. yesegg
  2194. I did find a new way to get high but I can't disclose it because the community is a shithole stealing novel substances to make money. Whoever doesn't steal likes talking and it eventually ends up with Sirsad

    Sell it yourself :emoji_49:
  2195. are u mad hatterz?
  2196. They indeed are lool
  2197. who care for being credited

    it's nice to be credited but making money off of someone else's idea is straight Edison BS
  2198. Sell it yourself :emoji_49:

    Nootropic company from Croatia? you must be joking or don't know the situation here
  2199. Click to see attachment

    It was yanas find
  2200. Yana :Prayge:
  2201. Yana :Prayge:

    's
  2202. eggg
  2203. :emoji_44:
  2204. Nootropic company from Croatia? you must be joking or don't know the situation here

    :emoji_52~4:
  2205. I have been told multiple times I look like Michael Jackson
  2206. I can't see the resemblance at all
  2207. was wondering why people make these funny connections
  2208. many times someone says someone looks like someone else but to me never
  2209. Nootropic company from Croatia? you must be joking or don't know the situation here

    or maybe a partnership with an already established noot shop
  2210. or maybe a partnership with an already established noot shop

    tried that with sirsa
  2211. went well
  2212. best solution is to move out of this beautiful hell
  2213. tho' my heart jumps a beat just thinking about it
  2214. what's your chemical solution for heartbreak
  2215. was wondering why people make these funny connections

    Image
  2216. do he look like dababy?
  2217. do he look like dababy?

    he looks like A baby
  2218. lmfao
  2219. Image
  2220. Click to see attachment

    was that made using midjourney
  2221. was that made using midjourney

    yes
  2222. looks rly cool
  2223. Image
  2224. toad king in natural environment
  2225. midjourney is insane powerful
  2226. I decided to use substances and have fun in midjourney all winter until I go crazy
  2227. generate a hyperrealistic watermelon!
  2228. if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
  2229. 🍉
  2230. G
  2231. I just crushed a few kgs of watermellow
  2232. dam fr
  2233. why
  2234. kek did you even read my spam
  2235. it's not just for spam it's to send a message you know
  2236. uhh
  2237. wheres your spam 😅
  2238. didnt read it no
  2239. wheres your spam 😅

    if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
  2240. why

    if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
  2241. didnt read it no

    if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
  2242. yea but why crush it
  2243. if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
  2244. was the watermelon looking at you funny
  2245. was the watermelon looking at you funny

    if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
  2246. yea but why crush it

    if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
  2247. i love watermelons man im not a hater
  2248. i love watermelons man im not a hater

    btw do you know which melon is the best
  2249. no
  2250. which is the best 1
  2251. Image
  2252. ive seen those somewhere
  2253. dont know what theyre called
  2254. pure sugar
  2255. also highest in citrulline
  2256. the stats that eating 5 kg of watermelon is like consuming a citrulline supplement is for this one
  2257. not for the red one
  2258. that will never provide enough citrulline
  2259. makes your snake fat, pent up and ready to strike!
  2260. BOT

    GG , you just advanced to level 2!
  2261. makes your snake fat, pent up and ready to strike!

    tho you can crush the seeds of a normal one and still get a fat snake
  2262. bcs of arginine content
  2263. 🐍
  2264. So far Sialic acid is feeling really good. For those that don't know, Edible Bird's Nest as a Potential Cognitive Enhancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120600/ Molecular Mechanism Underlying Sialic Acid as an Essential Nutrient for Brain Development and Cognition https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649484/ Sialic acid is an essential nutrient for brain development and cognition https://pubmed.ncbi.nlm.nih.gov/19575597/ now you know.
    PubMed Central (PMC)
    Cognitive enhancement is defined as the augmentation of the mind's core capabilities through the improvement of internal or external information processing systems. Recently, the focus has shifted to the potential therapeutic effects of natural products ...
    Image
    PubMed Central (PMC)
    The early stages of neurodevelopment in infants are crucial for establishing neural structures and synaptic connections that influence brain biochemistry well into adulthood. This postnatal period of rapid neural growth is of critical importance for cell ...
    Image
    PubMed
    The rapid growth of infant brains places an exceptionally high demand on the supply of nutrients from the diet, particularly for preterm infants. Sialic acid (Sia) is an essential component of brain gangliosides and the polysialic acid (polySia) chains that modify neural cell adhesion molecules (NCA …
    Image
  2265. So far Sialic acid is feeling really good. For those that don't know, Edible Bird's Nest as a Potential Cognitive Enhancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120600/ Molecular Mechanism Underlying Sialic Acid as an Essential Nutrient for Brain Development and Cognition https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649484/ Sialic acid is an essential nutrient for brain development and cognition https://pubmed.ncbi.nlm.nih.gov/19575597/ now you know.

    what r u using
  2266. pure sialic acid?
  2267. that will never provide enough citrulline

    What about the rinds?
  2268. pure sialic acid?

    Pure.
  2269. Pure.

    can u provide sauce
  2270. Next Valley
    Buy Sialic Acid (N-Acetylneuraminic Acid) with a 30% stack discount from €20.55 /60 capsules. Next Valley supplies High Quality Sialic Acid with a Certificate of Analysis
  2271. I have steadily been increasing the dosage. Started with just 600mg and worked my way up to 2 grams.
  2272. Breast milk has been shown to contain high levels of sialic acid and there's been studies evaluating how the time period of breastfeeding effects infant IQ.
  2273. did u notice anything
  2274. Keep in mind that I've only been using it for a couple of days. But with that being said, I feel more alert for 2-3 hours after taking it and weirdly enough since taking it I have incorporated some small new things to my routine out of the blue. Pure optimization to already successful practises. Also light brain tingles.
  2275. what's your chemical solution for heartbreak

    Anti empathy
  2276. it's nice to be credited but making money off of someone else's idea is straight Edison BS

    There was a time where getting money from work is like getting it from bank
  2277. You did not tested the power of biology
  2278. Click to see attachment

    Image
  2279. Image
  2280. Would getting good consistent cardio balance out the working memory deficits of cannabis use??????
  2281. Would getting good consistent cardio balance out the working memory deficits of cannabis use??????

    I don't think it would completely balance it but it would help. I have personally fixed a guy's brain from years of cannabis abuse. Improved his average grade by 2.
  2282. BOT

    GG , you just advanced to level 3!
  2283. Would getting good consistent cardio balance out the working memory deficits of cannabis use??????

    Not with concurrent use. If you stop consuming yes but you need to do as much as possible though you can do it at an easy pace. I recommend bike cycling because ligament and tendon injuries and insults are almost impossible to happen.
  2284. Also if you stop doing the exercise the deficits will quickly return. Benefits are best while exercising, which is why I recommend a stationary bike if you need it to do something on a computer. Otherwise normal bikes are better because of the mindfulness needed to pay attention to the road, this helps rebuild gray matter as well.
  2285. Anti empathy

    I meant homesick heartbreak, it doesn't work for this. I'm low empathy since 2015 or so
  2286. I’m gonna bring it into mspaint and make an annotated version for my notes
  2287. Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
    Image
  2288. Makes sense since they’re both very involved in hunger i guess
  2289. Stress too
  2290. Neat
  2291. Memantine day
  2292. Alpha frequency
  2293. Translationary symmetry
  2294. Let's go motherfuckers.
  2295. Make small step for a man, large for mankind
  2296. BOT

    GG , you just advanced to level 4!
  2297. Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree

    GPR12, the one related to working memory, is also right there
  2298. Dreams r on point
  2299. Listen to Water (Alpha 8Hz (Isochronic)) by DJ Taz Rashid on #SoundCloud https://soundcloud.app.goo.gl/84vAL
  2300. Resting heart rate
  2301. Less than zero
  2302. Makes you feel like you don't even need to breathe anymore
  2303. 🐸
  2304. thought about what you said and I no longer think intelligence is just as simple as g factor
  2305. I meant homesick heartbreak, it doesn't work for this. I'm low empathy since 2015 or so

    when I'm very low in empathy (anafranil withdrawal) I don't have any type of it and completely empathy none responsive, but anyway blocking serotonin will harm you more then benefit you, it rarely act as depressant
  2306. dopamine 3 would greatly help
  2307. thought about what you said and I no longer think intelligence is just as simple as g factor

    Glad u opened your mind
  2308. Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree

    An environment with excess resources becomes r-selected Lots of feeding = lots of breeding perhaps
  2309. The night before
  2310. An environment with excess resources becomes r-selected Lots of feeding = lots of breeding perhaps

    But only if it is still space restricted. I.e. mouse Utopia experiment
  2311. why your account don't show up, I want to see you super mod x_x
  2312. I found some old data showing a working memory test my psych professor administered to me. I thought I had found the perfect and most simplistic test. Yes it was only loosely correlated to Iq which probably isn't even the full picture
  2313. why your account don't show up, I want to see you super mod x_x

    ????? But I am!!!! D:
  2314. I guess then I'll redefine my goal as general cognitive enhancement in any possible fashion I can muster.
  2315. I found some old data showing a working memory test my psych professor administered to me. I thought I had found the perfect and most simplistic test. Yes it was only loosely correlated to Iq which probably isn't even the full picture

    Little steps 😅
  2316. I don't think I see Iq as one pure thing anymore
  2317. I don't think I see Iq as one pure thing anymore

    Nice
  2318. ????? But I am!!!! D:

    Image
  2319. Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree

    I am going to worship this tree I want to know it inside out It will be my axis mundi -what holds it all together
  2320. Click to see attachment

    Owh rip I am always invisible mode lol
  2321. You did not tested the power of biology

    no one did. I'm on the trajectory
  2322. So I would probably aim to increase any of the following. When it comes to intelligence - long term memory - processing speed - working memory - implicit skill acquisition - general brain health - mental stamina
  2323. BOT

    GG , you just advanced to level 1!
  2324. So I would probably aim to increase any of the following. When it comes to intelligence - long term memory - processing speed - working memory - implicit skill acquisition - general brain health - mental stamina

    discipline
  2325. That too
  2326. Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree

    Holy crap those are also the sphingosine 1 phosphate receptors also crammed into that tiny branch along with MCR and endocanninoids!!!!! They’re all so closely related
  2327. Only thing I’m not familiar with on that branch is LPAR
  2328. Holy crap those are also the sphingosine 1 phosphate receptors also crammed into that tiny branch along with MCR and endocanninoids!!!!! They’re all so closely related

    You are really into this
  2329. I wish I could join you
  2330. You are really into this

    Treeeeeeeeeeesssss
  2331. So I would probably aim to increase any of the following. When it comes to intelligence - long term memory - processing speed - working memory - implicit skill acquisition - general brain health - mental stamina

    Processing speed dopamine 1 , alpha 2 a adrenaline Mental stamina =dfo IN
  2332. The treeeees connect it allll
  2333. Web of wyrd
  2334. Maybe humans are just too evolved to get wm increases from dfo
  2335. no one did. I'm on the trajectory

    Ask on MDMA and methylene blue
  2336. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor.

    Jukesta did you see this orphan receptor we found?????
  2337. Or ask me on nmda-tune
  2338. It is right on that branch of the tree too
  2339. Jukesta did you see this orphan receptor we found?????

    No what's it about
  2340. No what's it about

    It’s responsible for a lot of genetic variance in working memory Highly implicated
  2341. It’s closely related to endocannabinoid receptors which are also known to mess with working memory
  2342. Mh
  2343. Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree

    Tree pic
  2344. There some impossibility you can find functional agonist that produce canabiniod effect and enhance memory
  2345. Cb1
  2346. There some impossibility you can find functional agonist that produce canabiniod effect and enhance memory

    i did
  2347. What
  2348. there's multiple of these compounds in nature
  2349. I just need to isolate and produce large quantities
  2350. Thc?
  2351. will send you guys samples
  2352. BOT

    GG , you just advanced to level 2!
  2353. Thc?

    no it's unrelated to cannabis
  2354. Urb 597?
  2355. We need to breed bacteria Or inject them with the dna to make the right enzymes
  2356. Urb 597?

    noo
  2357. Well
  2358. So it's a cb1 receptor agonist?
  2359. not really, but it does have the same effects
  2360. Can you just say what it is?
  2361. no
  2362. that would cost me hundreds of thousands
  2363. offfered this info for 0.5 btc
  2364. Well okay as long as I get a sample
  2365. now the price is 1 btc
  2366. Well okay as long as I get a sample

    probably
  2367. Good enough
  2368. Continuing this topic I have noticed some interesting effects from high doses of weed in the past
  2369. I will first test it on myself
  2370. like any respectable biohacker
  2371. Continuing this topic I have noticed some interesting effects from high doses of weed in the past

    I do high dose once a month
  2372. Idc about profit or getting high tbh I’m just curious at this point wtf :despair: :despair: :despair: :despair: :despair: :despair: :despair:
  2373. riiip
  2374. I don't consume it anymore other than that
  2375. I try to avoid it but
  2376. I can keep lip zeal 🤐🥺
  2377. I'll admit it has acutely exploded my ability to visualize in the past
  2378. this is Terrence Mckenna method but he was clueless about reward pathways and never had the willpower to do it like that as result
  2379. I have found ways to make me not have the desire to redose next day
  2380. but increases effects on the day of consumption
  2381. tomorrow is the day
  2382. once youve weighed everytthing you take out for 2 years

    Yeah tbh I've been weighing stuff for about a month now and more often than not get it within a few mg of the target weight in the first measurement
  2383. I was stuck reading some old messages 💀
  2384. tomorrow is the day

    The day you get lit?
  2385. The day you get lit?

    yes
  2386. Nice
  2387. every 15th of the month
  2388. I'll probably use lsd soon
  2389. What about oleamide for cb1?
  2390. What about oleamide for cb1?

    that will impair cognition
  2391. I think it was also 5ht2c antagonist and maybe something
  2392. that will impair cognition

    Prolly
  2393. What's this CB receptor talk
  2394. Apparently cb1 is related to variance in wm
  2395. Which I'm actually inclined to believe based on my experience with cannabis
  2396. Image
    Peptide hormones and growth factors bind to membrane receptors and regulate a myriad of processes in insects and other metazoans. The evolutionary relationships among characterized and un-characterized (“orphan”) receptors can provide insights into receptor-ligand biology and narrow target choices in deorphanization studies. However, the large n...
  2397. Apparently cb1 is related to variance in wm

    in a perfect world we don't need cb1 agonism
  2398. but the world is very polluted
  2399. Do you know anything about urb 597
  2400. so if you go live on a mountain at say 1-2000 m elevation you will be clearheaded all the time
  2401. Do you know anything about urb 597

    yes FAAH inhibition sucks
  2402. Really and why's that
  2403. I think this tree includes non-human proteins :/
  2404. Urb 597 would supposedly upregulate cb1
  2405. As well as other things
  2406. And I've heard a rumor that it can induce lucid dreaming
  2407. I'd like to know more
  2408. Image
  2409. Image
  2410. Click to see attachment

    thoughts?
  2411. Which I'm actually inclined to believe based on my experience with cannabis

    Well it defiantly has been shown to decrease it after a while, so we atleast know it interacts with wm and that it has some role in the mechanisms of wm
  2412. Well it defiantly has been shown to decrease it after a while, so we atleast know it interacts with wm and that it has some role in the mechanisms of wm

    What do you think about cb1s relation to anxiety and motivation
  2413. BOT

    GG , you just advanced to level 3!
  2414. Click to see attachment

    I had same effects from high dose CBD
  2415. a bit less than a gram daily for a week
  2416. What do you think about cb1s relation to anxiety and motivation

    Probably has some role modulating HPA axis It’s related to MCRs and also has obvious effects on stress Idk about motivation tho
  2417. made me not give a f about anything
  2418. very worrying state
  2419. So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth
  2420. What do you think about cb1s relation to anxiety and motivation

    Working memory is essential for the organization of goal-directed behavior, as it maintains task-relevant information.
    I wrote this earlier in response to that quote:
    Working memory holds information to direct goals as well as the information to accomplish those goals? It holds the check list and equation sheets to solve? So say your working memory is divided into 7 slots to hold information. If you have 5 goals instead of 1 does that limit how much free processing power you have to pursue those goals? (5 different classes in school) People with adhd or autism who have a specific interest, I feel like that occupies too much space in their mind at all times for them to focus. Or maybe not.
  2421. BOT

    GG , you just advanced to level 6!
  2422. So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth

    Work capacity > IQ anyways
  2423. So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth

    indeed
  2424. it changes your personality
  2425. Have you taken?
  2426. I am usually a very worried person. I take care that I and everybody around me are safe
  2427. Hmm
  2428. thoughts?

    I’ve never heard of Urb, looks interesting
  2429. but taking CBD completely removes this aspect of my personality
  2430. which is a detriment if you ask me
  2431. it would decrease intelligence by virtue of decreasing negative affect
  2432. Hyper vigilance is probably correlated to IQ
  2433. This is difficult
  2434. indeed
  2435. if I could I would upregulate FAAH
  2436. Really
  2437. Hyper vigilance is probably correlated to IQ

    IQ is prerequisite to hypervigilance but hypervigilance is necessary to apply intelligence in everyday life
  2438. What comes to mind when I think about vigilance is some 100 IQ go getter 😂
  2439. So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth

    CB1 agonism doesn’t acutely enhance wm does it????????????? I’ve read that it can reduce it up to 3 months after cessation though.
  2440. CB1 agonism doesn’t acutely enhance wm does it????????????? I’ve read that it can reduce it up to 3 months after cessation though.

    Nvm I misresd the paper u sent
  2441. It was
  2442. Gpr12
  2443. Check the one also linked directly above the one I posted
  2444. Check the one also linked directly above the one I posted

    This was mostly a misunderstanding
  2445. But
  2446. I'm still interested in cb1 and urb 597
  2447. I'm still interested in cb1 and urb 597

    it's funny to think about these things
  2448. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871916/
    A primary function of the endocannabinoid signaling system is to maintain or recover homeostasis following psychological and physiological threats.
  2449. More HPA loreeeeeeeeeee HPA is core
  2450. Image
  2451. plenty of paradoxes when it comes to this.
  2452. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871916/ > A primary function of the endocannabinoid signaling system is to maintain or recover homeostasis following psychological and physiological threats.

    This part is especially interesting
    We discuss recent findings that corticotropin-releasing hormone in the amygdala enables hypothalamic-pituitary-adrenal axis activation via an increase in the catabolism of the endocannabinoid N-arachidonylethanolamine.
    Image
  2453. So the endogenous cannabinoid is constantly signalling to put the breaks on the HPA axis, and CRH activates it by increasing the breakdown of that endocannabinoid
  2454. I might try urb 597
  2455. See if it does anything to wm
  2456. See if it does anything to wm
  2457. I might try urb 597

    it's cheap?
  2458. Stupid ideas
  2459. Shortsighted
  2460. Devoid of lateral thought
  2461. And nvm
  2462. Too bad there's no grp12 agonist
  2463. HPA axis controls stress and dealing with the problems causing our stress
  2464. elevated cortisol induced by stress increases serotonin uptake
  2465. (2a) Serotonergic mindset is problem solving mode
  2466. Wut
  2467. Imo
  2468. How does that follow
  2469. Hey how are you all
  2470. Can u link study about 5ht uptake
  2471. This is madness
  2472. When I take psychedelics I feel like I can solve any problem, answer any question I feel capable of any and everything on psychedelics, like I’m at 1000% functioning
  2473. Hey how are you all

    With a resting heart rate less than zero
  2474. When I take psychedelics I feel like I can solve any problem, answer any question I feel capable of any and everything on psychedelics, like I’m at 1000% functioning

    Psychedelics made me feel like I was in problem solving mode
  2475. When I take psychedelics I feel like I can solve any problem, answer any question I feel capable of any and everything on psychedelics, like I’m at 1000% functioning

    I don't know if you actually are able to
  2476. With a resting heart rate less than zero

    You've transcended us all 😲
  2477. Psychs are known to make people think they are smarter than they are and see patterns where there isn't any
  2478. I agree it increases pattern recognition
  2479. Just wanted to put this out here: I think PRL could interact with GPR139
  2480. That's all
  2481. I will disappear now.
  2482. How does that follow

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses
    Image
    PubMed Central (PMC)
    Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the ...
    Image
  2483. It’s a robin carhart harris theory
  2484. Can u link study about 5ht uptake

    https://pubmed.ncbi.nlm.nih.gov/12467107/ I could be wrong, just googled it and read what google said
    PubMed
    Stress and depression are characterized by elevation of circulating cortisol, as well as by changes in physiological functions. In this study, we addressed the possibility that elevated cortisol is also associated with the origin and development of depression. We report here that cortisol at the nM- …
    Image
  2485. I will disappear now.

    :boywave:
  2486. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses

    you're golden
  2487. Farewelllll
  2488. that pic
  2489. omg
  2490. my mind on a piece of paper
  2491. you're golden

    JC Denton sent that study a while back 🙏
  2492. JC Denton sent that study a while back 🙏

    that motherfucker
  2493. 🙏
  2494. that pic

    Imagine if you couldn't passively cope and felt forced to actively engage every arrogant idiot who ever annoyed you to reduce how much their existence bothers you lol …..I wouldn’t know xdddd :withered:
  2495. Imagine if you couldn't passively cope and felt forced to actively engage every arrogant idiot who ever annoyed you to reduce how much their existence bothers you lol …..I wouldn’t know xdddd :withered:

    kek I'm close
  2496. There’s a place for both 1A and 2A
  2497. I heard 5meo dmt targets 5htp1a pretty well
  2498. I heard 5meo dmt targets 5htp1a pretty well

    all classical psychs target it
  2499. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses

    Also idk if you’ve watched neon genesis evangelion -but I think how shinji accepts the situation his father puts him in (passive cope) and just fights the robots (active cope) it demonstrates a lot how the two systems can work together synergistically. They aren’t necessarily opposing i think.
  2500. Meo seems mostly like 1a
  2501. stupid question, how does the brain change when it goes from shugar metabolism to ketone metabolism.
  2502. HPA axis controls stress and dealing with the problems causing our stress

    Does cannabis decrease serotonergic activity?
  2503. I'm not gonna lie mice wm studies seem like shit
  2504. Not entering the same room twice is basically the extent of mice wm testing
  2505. all behaviour mice/rat studis that include male researcher are scewed anyway. They react way more stressed around male smell. And as a rat breeder i can confirm that (and used that behaviour multiple times)
  2506. I feel like that could include so much more than pure wn
  2507. Chimp studies would be a million times better since they can actually be taught wm games
  2508. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871916/ > A primary function of the endocannabinoid signaling system is to maintain or recover homeostasis following psychological and physiological threats.

    cannabinoid receptor 1 (CB1R) signaling can both inhibit and potentiate the activation of the hypothalamic-pituitary-adrenal axis by stress tho
  2509. cannabinoid receptor 1 (CB1R) signaling can both inhibit and potentiate the activation of the hypothalamic-pituitary-adrenal axis by stress tho

    Makes sense
  2510. It’s ofc more complex than first would seem :despair:
  2511. BOT

    GG , you just advanced to level 4!
  2512. It’s ofc more complex than first would seem :despair:

    It's all brutally complex
  2513. Does cannabis decrease serotonergic activity?

    no it increases it somehow
  2514. It's all brutally complex

    Trees will organize for us :Prayge:
  2515. We need smarter drugs
  2516. 5ht2a
  2517. Well I need sleep gnnnnnnnn
  2518. We need drugs that do more than agonism or pam
  2519. and not all got the same amount of canabis receptors, i assume my amount is lower than the average (or somegow different in an other way?)
  2520. That actually have complex mechanisms
  2521. Like imagine drugs that would upregulate gamma wave activity directly
  2522. Tbh I'm just gonna try out my plans when it comes to cognitive enhancement.
  2523. Jukesta I believe in you
  2524. is nitraria komarovii worth pursuing or nah
  2525. iyo
  2526. For all ik it could be recreationally, hallucinogenic or whatever
  2527. is nitraria komarovii worth pursuing or nah

    if u can get viable seeds yes
  2528. Gnnnnnnnn chattt!!!!!!!!!!!!!!!!!!
  2529. Click to see attachment

    Where the video that you look like on MDMA buzz
  2530. :emoji_1:
  2531. Where the video that you look like on MDMA buzz

    need nitro to upload it xD
  2532. Click to see attachment

    yo
  2533. Image
  2534. toad king out. about to merge with my swamp
  2535. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses

    u know Neti... 5HT1A has many problems. Nooking 5HT2A is one of them
  2536. they're opposing forces. life can either be easy, stuff gets put under the rug, or it can be hard, yet better by the day
  2537. second law of thermodynamics
  2538. whatever doesn't improve will get worse
  2539. so 5HT1A is an evil receptor
  2540. it is C.O.P.E.
  2541. /cancerous obedient people externalizing
  2542. We need to connect the TAFFA /thoughts actions feelings facts associations/ to gain the holy trinity of I /intuition intention intervention/, master the MAD /meaning aspiration dedication/ LAD /liberty alternation discipline/, defeat the DAD /distractions addictions delusions/ and finally, above all, complete the MISSION /mapping investigation structure superintendence infrastructure operation naturalization/.
  2543. Why lol
  2544. Click to see attachment

    Hot.
  2545. /cancerous obedient people externalizing

    The C.O.N.S.P.I.R.A.C.Y., short for Cliques Of Normals Secretly Planning Insidious Rituals Aimed at Controlling You
  2546. they're opposing forces. life can either be easy, stuff gets put under the rug, or it can be hard, yet better by the day

    This is an interesting way of putting it
  2547. Is this why DMT can be so scary
  2548. Why lol

    to distract you from the MISSION
  2549. 😆
  2550. Thinking about my plan tbh
  2551. I haven't been set on actions
  2552. Prob just gonna keep taking ha p6
  2553. fuck peptides
  2554. why do you dislike peptides
  2555. because they always mimic endogenous peptides or proteins
  2556. Most of the noots I have are acute
  2557. this makes them dangerous because the body can develop antibodies
  2558. it can do so for small molecules as well, but in that case you just stop taking the drug
  2559. in the case of the peptide you can't stop taking it because you're producing it
  2560. I take it infrequently
  2561. I think it might have improved my vision
  2562. secondly, peptides are never orally active which is the safest RoA other than transdermal
  2563. because of infections mainly
  2564. but also it's easier to administer
  2565. Hm
  2566. they're also never active sublingually unless it's just a dipeptide
  2567. I've fought about that
  2568. I use the same syringe every time I take it although I wash with hot water first
  2569. buccally too
  2570. Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death https://pubmed.ncbi.nlm.nih.gov/30684217/ Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506974/ Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217549/ NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder https://pubmed.ncbi.nlm.nih.gov/29770430/ Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder https://pubmed.ncbi.nlm.nih.gov/15635701/ NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570679/ Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364372/ Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645690/ Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925045/ Epinephrine Released During Traumatic Events May Strengthen Contextual Fear Memory Through Increased Hippocampus mRNA Expression of Nr4a Transcription Factors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167477/ A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631643/ Pharmacological activation of Nr4a rescues age-associated memory decline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917472/
    PubMed
    NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological features. In the cell nuclei of the central nervous system, it is widely expressed and identified as a crucial regulator of dopaminergic (DA) neuronal differentiation, survival, and maintenance. Importantly, it ha …
    Image
    PubMed Central (PMC)
    Nr4a1 and Nr4a2 are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression ...
    Image
    PubMed Central (PMC)
    Dopaminergic neurons form in diverse areas of the vertebrate di- and mesencephalon to constitute several major neuromodulatory systems. While much is known about mammalian mesencephalic dopaminergic neuron development, little is known about the specification ...
    Image
    PubMed
    NR4A2, a member of the nuclear receptor superfamily, is involved in modulation of target gene transcription, regulating several developmental processes such as regulation of cellular homeostasis, neuronal development, inflammation and carcinogenesis. 2q24.1 deletions are extremely rare, and only 1 p …
    Image
    PubMed
    Attention deficit hyperactivity disorder (ADHD) is a highly heritable and common disorder thought to arise, in part, from alterations in dopamine function. NR4A2, or Nurr1, is an orphan nuclear receptor implicated in the development of dopaminergic cells of the ventral tegmental area (VTA) and the s …
    Image
  2571. Development and Differentiation of Midbrain Dopaminergic Neuron: From Bench to Bedside https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349799/ Failure of Glial Cell-Line Derived Neurotrophic Factor (GDNF) in Clinical Trials Orchestrated By Reduced NR4A2 (NURR1) Transcription Factor in Parkinson’s Disease. A Systematic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943926/ NR4A Transcription Factor Family: Key Regulators of Memory Formation https://cdn.discordapp.com/attachments/962009752488013834/1008362881634533386/296498079.pdf (thanks blank ❤️) potential pro-oncogene (or not, varies on a case-by-case basis): https://pubmed.ncbi.nlm.nih.gov/22566377/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864866/
    PubMed
    Nuclear receptors are of integral importance in carcinogenesis. Manipulation of classic ligand-activated nuclear receptors, such as estrogen receptor blockade in breast cancer, is an important established cancer therapy. Orphan nuclear receptors, such as nuclear family 4 subgroup A (NR4A) receptors, …
    Image
    PubMed Central (PMC)
    The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli, and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1) play an important role in maintaining cellular homeostasis and in pathophysiology. ...
    Image
  2572. wys
  2573. Wtf
  2574. Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death https://pubmed.ncbi.nlm.nih.gov/30684217/ Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506974/ Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217549/ NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder https://pubmed.ncbi.nlm.nih.gov/29770430/ Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder https://pubmed.ncbi.nlm.nih.gov/15635701/ NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570679/ Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364372/ Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645690/ Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925045/ Epinephrine Released During Traumatic Events May Strengthen Contextual Fear Memory Through Increased Hippocampus mRNA Expression of Nr4a Transcription Factors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167477/ A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631643/ Pharmacological activation of Nr4a rescues age-associated memory decline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917472/

    dude
  2575. im a nr4a goon
  2576. I have no attention span rn
  2577. dosed memantine
  2578. Chlo
  2579. wait i have something that will give u the attention span
  2580. wait i have something that will give u the attention span

    it will come back in a few days
  2581. itll make ur snake pent up.
  2582. I did this on purpose
  2583. Overexpression of Nurr1 up-regulates Pitx3, TH and Vmat2 mRNAs
    Image
  2584. Overexpression of Nurr1 up-regulates Pitx3, TH and Vmat2 mRNAs

    I know about Nurr1
  2585. BOT

    GG , you just advanced to level 13!
  2586. nr4a = nurr1
  2587. why you talking to me like I'm some noob 😛
  2588. These are the drugs I'm eye balling: Ara 290 IN Insulin Clemastine Phosphitidylserine
  2589. D:
  2590. Thoughts?
  2591. seems good
  2592. i believe in u jukesta.
  2593. take clemastine close to bed though
  2594. Nurr1 is a good thing
  2595. do u have agonist?
  2596. Nook it roflmao
  2597. chloroquine
  2598. Nook it roflmao

    why
  2599. why

    nookin has suddenly got a whole new meaning
  2600. Nurr1 agonist nooks it
  2601. Ara 290 to unregulate epo Insulin which probably has a myriad of benefits Clemastine apparently myelinates the occular nerve Phosphatidylserine for myelination
  2602. and antagonist stops the explosion 😛
  2603. Also rapamycin
  2604. Ara 290 to unregulate epo Insulin which probably has a myriad of benefits Clemastine apparently myelinates the occular nerve Phosphatidylserine for myelination

    u putting it all in your eyes or wut
  2605. and antagonist stops the explosion 😛

  2606. BOT

    GG , you just advanced to level 3!
  2607. Which due to autophagy should help with synaptic pruning and de-noising my brain
  2608. u putting it all in your eyes or wut

    I want better vision
  2609. I want better vision

    did u try CDPC
  2610. I think my brain is noisy right now from neurogenics
  2611. it improved my vision substantially
  2612. did u try CDPC

    Nope havent
  2613. Tropoflavin as well
  2614. I think my brain is noisy right now from neurogenics

    you've accumulated too much chloride
  2615. go ride a bike
  2616. for a few hours
  2617. you'll feel better
  2618. Chloride?
  2619. From what?
  2620. also NMDA antagonist will help
  2621. From what?

    from exogenously evoked BDNF
  2622. go ride a bike

    Was just about to ride a bike actually
  2623. from exogenously evoked BDNF

    Really
  2624. the neurons start piling chloride
  2625. exercise-induced BDNF gets rid of this chloride accumulation
  2626. it has differential effects
  2627. When doing digit span I notice harder time reading and more noise than I used to
  2628. also NMDA antagonist will help

    Other than NMDA antags is there anything else you can use
  2629. Yea I've been wanting to exercise more
  2630. Other than NMDA antags is there anything else you can use

    bromides but I don't recommend this you will fuck yourself permanently from it
  2631. Exercise seems to be the most cognitively enhancing thing for me
  2632. it has differential effects

    wtf
  2633. bromides but I don't recommend this you will fuck yourself permanently from it

    Thoughts on using rapamycin to de noise?
  2634. wtf

    I don't get surprised by these things anymore. Exercise uses every single mechanism in the best possible way
  2635. I've been noticing an increase in autistic like symptoms
  2636. Noise and chaos agitates me more than it ever has
  2637. Thoughts on using rapamycin to de noise?

    in my experience it only creates more noise
  2638. Really
  2639. I thing autophagy would help cut down on loose synapses
  2640. yes. but fasting + rapamycin restarts the whole thing. neurogenics have effects similar to the honeymoon period for a while after the fast
  2641. rapamycin alone just creates a whole lot of confusion
  2642. Restarts?
  2643. BOT

    GG , you just advanced to level 5!
  2644. Wdym by that
  2645. Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death https://pubmed.ncbi.nlm.nih.gov/30684217/ Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506974/ Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217549/ NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder https://pubmed.ncbi.nlm.nih.gov/29770430/ Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder https://pubmed.ncbi.nlm.nih.gov/15635701/ NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570679/ Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364372/ Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645690/ Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925045/ Epinephrine Released During Traumatic Events May Strengthen Contextual Fear Memory Through Increased Hippocampus mRNA Expression of Nr4a Transcription Factors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167477/ A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631643/ Pharmacological activation of Nr4a rescues age-associated memory decline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917472/

    pls remind me if I forget I'll review this in a few days
  2646. Restarts?

    I just explained lol
  2647. it's like taking neurogenics for the first time
  2648. similar
  2649. Oh
  2650. Wtf why
  2651. I guess it is effective at cutting the noise
  2652. but it does give me a headache
  2653. the day I take Rapa
  2654. I take it on day 3 of the fast
  2655. Dose?
  2656. when AMPK is the highest
  2657. Dose?

    4-6 mg oral
  2658. Oh
  2659. capsulated
  2660. I assumed you would use IN
  2661. no
  2662. I'm not Pax
  2663. and I don't advocate that
  2664. Isn't oral rapa more systemic?
  2665. it's just a meme
  2666. In rapa?
  2667. Isn't oral rapa more systemic?

    yes
  2668. I know that drugs taken IN target the brain better
  2669. but it is unknown what is the difference
  2670. For the most part
  2671. but it is unknown what is the difference

    What's your opinion on pax
  2672. What's your opinion on pax

    I have not talked to him for a long time
  2673. Like it's true that he can be sporadic but he did what pretty much everyone in the nootropic community does
  2674. last time I heard from him he sent me a voice recording yelling at me for 2 mins straight
  2675. He did his research he found some things that hypothetically would increase cognition
  2676. And yet those things did not increase cognition
  2677. Namely dfo
  2678. By all means dfo should have worked
  2679. It had lots of promise
  2680. Yet it didn't live up to the hype
  2681. the main problem with brain abilitys, the amount you can increase is limited. You can't turn an idiot into a genious (maybe transhumanists can do that sometime with brainimplants combined with AI)
  2682. same with lifespan. You may be able to get 10-50 extra years, but that's it
  2683. He did his research he found some things that hypothetically would increase cognition

    He tries to find fringe substances no one else used and use them to increase cognition according to his holistic understanding of the brain
  2684. This is similar to my approach, except I don't use substances that may cripple me in some way
  2685. True but you have to admit dfo had alot of research
  2686. First and foremost I look for substances that already have human or at least animal research behind them
  2687. This is similar to my approach, except I don't use substances that may cripple me in some way

    no risk no fun, i use carcinogenes
  2688. no risk no fun, i use carcinogenes

    this is a very irresponsible thing to say in this space
  2689. no risk no fun, i use carcinogenes

    Lol
  2690. should i lie about the carcinogen abillity of igf1 and vit b3? it's a tradeoff
  2691. I am like a golden mean of Sirsad and Pax, one of them has no holistic understanding, while the other applies no risk management
  2692. b3 lol how
  2693. should i lie about the carcinogen abillity of igf1 and vit b3? it's a tradeoff

    that's not what I meant
  2694. 'no risk no fun'
  2695. ah yeah, that part
  2696. Inhibiting FAO and SIRT is anti cancer
  2697. we need to strive to prevent risk at every cost
  2698. because that will make us go further
  2699. sirt reminds me, i should eat some of my shugar limited wild cherrys again... taste good and healtgy
  2700. sirt reminds me, i should eat some of my shugar limited wild cherrys again... taste good and healtgy

    dude where r u
  2701. long gone cherry season here
  2702. Click to see attachment
  2703. we need to strive to prevent risk at every cost

    my mindset is different, wevhave to educate on tge tradeoffs; you wabt biger musckes and a longer dong? No problem HOWEVER your cancer risk will increase and you will suffer the following list of symptoms (insert agromegaly description)
  2704. my mindset is different, wevhave to educate on tge tradeoffs; you wabt biger musckes and a longer dong? No problem HOWEVER your cancer risk will increase and you will suffer the following list of symptoms (insert agromegaly description)

    I have ways to grow muscle without cancer risk
  2705. dude where r u

    made jam without shugar, the substances won't be destroyed if not heated above 120 (or something like that)
  2706. u know
  2707. tried that, got to low natural backgroubd igf1 in my body
  2708. if you find me a piece of evidence showing exercise causes cancer I'll give up everything to your approach
  2709. yet it increases IGF1
  2710. yet it grows muscle
  2711. but this is just an example
  2712. so many interventions that grow muscle yet decrease cancer risk
  2713. exercuse does not cause cancer but it is low, tidious and bot everybody can get the same results based on their genetics
  2714. time and tissue selectivity of interventions is key
  2715. and to see the cancer risk, i give my 17 year old cat calf liver, she loves it, it prevents muscledystrophy and i will see how big the cancer risk is truly.
  2716. exercuse does not cause cancer but it is low, tidious and bot everybody can get the same results based on their genetics

    I don't mind the work
  2717. I have time because of the antiaging interventions
  2718. I have willpower because of the cognitive enhancement
  2719. so why not
  2720. it all started because i wabted to grow my cheekbones/chin. That failed/was to slow however the musclegrowth is excelent. GH gut was a problem because of training problems
  2721. Liver fr gave you acormegaly and GH gut?
  2722. Liver fr gave you acormegaly and GH gut?

    plot twist: the BCAA excess gave him visceral fat
  2723. acromegaly simptoms. And the GH gut just started to apear once i trained my abs. It disapeared when i trained the inner abs (vaccum is the training method that helps)
  2724. acromegaly simptoms. And the GH gut just started to apear once i trained my abs. It disapeared when i trained the inner abs (vaccum is the training method that helps)

    how old r u
  2725. over 30
  2726. plot twist: the BCAA excess gave him visceral fat

    BCAA doesn't make your hands grow from M to XL
  2727. BCAA doesn't make your hands grow from M to XL

    tru
  2728. 🍉
  2729. BCAA doesn't make your hands grow from M to XL

    we'll just call it the weird growth action
  2730. and attribute it to an unknown force we'll look for later
  2731. BCAA doesn't make your hands grow from M to XL

    just temporary XL for a month. Before that easy to wear M gloves. After they shrunk back (little swollen) tgey where barely L but the gloves didn't break anymore therefore L
  2732. just temporary XL for a month. Before that easy to wear M gloves. After they shrunk back (little swollen) tgey where barely L but the gloves didn't break anymore therefore L

    bone growth cannot revert
  2733. what you had was water retention from the inflammation
  2734. bone growth cannot revert

    XL was partyally because the tissue grew/swollen (happend in my face as well) and the bonegrowth was slower than the tissue growth. And yes, not reversable. Still size L hands. And i assume if i had more calcium in my diet, the bones could have grown further. But that's just an asumption
  2735. Before that i fit easily in site M gloves. Now i fit barely in size L and rip apart size M gloves
  2736. PNAS
    Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
  2737. oh by the way i was on a strict carnivore diet during that time. Therefore the glucose intake was one bar of chokolate a week or nothing.
  2738. no matter what it was, it was direktly after eating 2,5 kg raw calf liver. And the symptoms matched IGF1 overexpression sideeffects.
  2739. I am like a golden mean of Sirsad and Pax, one of them has no holistic understanding, while the other applies no risk management

    Combine considerable impulsivity and smartness with curiosity and you will solve everything
  2740. You just described me
  2741. Combine considerable impulsivity and smartness with curiosity and you will solve everything

    I lack the impulsivity. Every move I make and the next 5 after that are meticulously calculated.
    This has brought me great success in life but has also hindered me in other ways.
  2742. I lack the impulsivity. Every move I make and the next 5 after that are meticulously calculated. This has brought me great success in life but has also hindered me in other ways.

    i was like that once, too. With age comes the attitude "just du stuff and see what happens"
  2743. I've used a dirty Nurr1 agonist that paradoxically reduced dopamine availability
  2744. it was hell
  2745. zero motivation until it was completely gone from my organism. recovered with modafinil
  2746. if u know a selective agonist let's go
  2747. what gives me motivation to do stuff, but i don't want to do it. Removing my smartphone. I assume it is way to efficient in removing bordom for my own good...
  2748. what gives me motivation to do stuff, but i don't want to do it. Removing my smartphone. I assume it is way to efficient in removing bordom for my own good...

    tried that
  2749. with an antipsychotic removing stimuli will not help
  2750. i assume at this point, your brain became an abnormallity anyway (if you where born with a normal one?) and therefore everything has to be discovered for your specific one anyway
  2751. i assume at this point, your brain became an abnormallity anyway (if you where born with a normal one?) and therefore everything has to be discovered for your specific one anyway

    one more person not to talk to ig
  2752. Dose?

    They made a long detailed post a while back in this channel you should look for
  2753. let's go motherfuckers
  2754. plot twist: the BCAA excess gave him visceral fat

    There is BCAAs in my creatine :/ I don’t eat that many per day, is it really that bad…??
  2755. There is BCAAs in my creatine :/ I don’t eat that many per day, is it really that bad…??

    in my experience using 10 g leucine and 4 g lysine for 2-3 weeks produced insulin resistance and gave me visceral fat which was hard to get rid of
  2756. I did not have visceral since I was 14 yrs old so that was out of ordinary
  2757. https://www.jneurosci.org/content/40/18/3675 unexpected results may follow
    The transcription factor Nurr1 has been identified to be ectopically induced in the striatum of rodents expressing l-DOPA-induced dyskinesia (LID). In the present study, we sought to characterize Nurr1 as a causative factor in LID expression. We used rAAV2/5 to overexpress Nurr1 or GFP in the parkinsonian striatum of LID-resistant Lewis or LID-p...
    Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Lev...
  2758. in my experience using 10 g leucine and 4 g lysine for 2-3 weeks produced insulin resistance and gave me visceral fat which was hard to get rid of

    next time you want to lose fat in specific areas, increase the bloodflow there while you are hungry/in energy defency. The ways for increasing the bloodflow are using muscles in that area/massage/hitting that area with a flat hand/vibration/chilly cream With increased blood flow, the fat cells get priority to be used
  2759. Message could not be loaded.

    Wait I actually didn’t understand what I was saying when I posted this.
  2760. I thought cortisol raised serotonin lmaoo
  2761. Whoops, embarrassing :/ I guess it still kinda makes sense tho lol
  2762. I lack the impulsivity. Every move I make and the next 5 after that are meticulously calculated. This has brought me great success in life but has also hindered me in other ways.

    Impulsivity is more benfitical then harm
  2763. I found my self go to work in things without caring much about the stress Ill get evuantulay due to responsapility a started to work 24h a day which solved my unproductivity.
  2764. I've used a dirty Nurr1 agonist that paradoxically reduced dopamine availability

    whatd u use
  2765. Time to give up on increasing IQ and figure out how to turn people into anime girls
  2766. whatd u use

    Doxycycline
  2767. Impulsivity is more benfitical then harm

    Mindfulness makes impulsivity safe. Mindless impulsivity will killya
  2768. Time to give up on increasing IQ and figure out how to turn people into anime girls

    Simp
  2769. Nah it's domination
  2770. Turn ur homies into anime girls and make a harem
  2771. Someone has been watching Andrew Tate
  2772. I did not have visceral since I was 14 yrs old so that was out of ordinary

    I had no visceral till like a few months ago :despair:
  2773. it’s not much but now I’m spooked
  2774. I have to start exercising to stay in shape :withered:
  2775. it’s cause I’m 21 in a few days
  2776. Do my FMD protocol
  2777. Reading about how fat cells never get removed once you’ve grown new ones was really spook Like once you fuck up and eat too much once, those fat cells are with you for life, and the only way to keep them from filling up from that point on is to exercise :Wuhhhh:
  2778. Ngl I’ve gotten away with eating pretty unhealthy and never exercising up until this point with no issue
  2779. Reading about how fat cells never get removed once you’ve grown new ones was really spook Like once you fuck up and eat too much once, those fat cells are with you for life, and the only way to keep them from filling up from that point on is to exercise :Wuhhhh:

    What? As in old fat is only burned after new fat is burned?
  2780. BOT

    GG , you just advanced to level 1!
  2781. What? As in old fat is only burned after new fat is burned?

    When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them.
  2782. When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them.

    Fat cells can get huge, some researchers even think people have a fixed number of fat cells
  2783. visceral fat cells are the ones that get huge and this implicates the insulin resistance, inflammation and so forth. We can gain fat cells but those are the cool subQ ones.
  2784. I want to keep as much subQ fat as possible while still maintaining zero visceral fat. exposing subQ fat to cold turns it to something similar to brown fat or what I like to call metabolic fat.
  2785. When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them.

    Am I retarded or can you not just lose weight to get rid of the fat cells
  2786. This kind of fat produces heat when stimulated by either cold or heat AND 5ht2a agonism
  2787. so it's fat that actually burns calories and keeps you insulin sensitive. Kind of like muscle
  2788. Is that “brown fat”
  2789. Is that “brown fat”

    no, it's white fat that has turned brown
  2790. it's not the same tissue but it has the same effects
  2791. no, it's white fat that has turned brown

    So it is brown fat?
  2792. I keep forgetting I block people for a reason
  2793. When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them.

    Adipocyte size 0.1mm empty , 0.3mm full we are fucked
  2794. I keep forgetting I block people for a reason

    :49_pepekek:
  2795. Adipocyte size 0.1mm empty , 0.3mm full we are fucked
    Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. In cell culture, adipocyte progenitors can also form osteoblasts, myocytes and other cell types. Ther...
    Adipocyte
    American Physiological Society
  2796. Butterflies are outt
    Image
  2797. Butterflies are outt

    hhmmm
  2798. I have trouble IDing Rosa species
  2799. rugosa came to mind when I saw that
  2800. Image
  2801. it must be rugosa
  2802. take it
  2803. it is nootropic
  2804. not the butterfly but the plant
  2805. Did anyone mega dosed rediola
  2806. not the butterfly but the plant

    :Holyshig:
  2807. Did anyone mega dosed rediola

    I’m curious as to what this would do
  2808. I could never!!!! looooool
  2809. Those butterflies don’t grow in factories y’know
  2810. my ex and I had a love triangle with a butterfly
  2811. he was magnificent
  2812. we fed the caterpillar and it turned into a butterfly
  2813. and he didn't want to leave my ex
  2814. for 2 week
  2815. I was jelly
  2816. Pretty bugs
  2817. BOT

    GG , you just advanced to level 7!
  2818. I’m curious as to what this would do

    Excepted to be less side effect in dose to dose potency of wallbutrine
  2819. There’s alotta grasshoppers flying around lately They kinda remind me of tiny winged reptiles lmfao
  2820. There’s alotta grasshoppers flying around lately They kinda remind me of tiny winged reptiles lmfao

    do you know those motherfuckers can smell cancer
  2821. even better than dogs
  2822. and can tell diff types of cancer apart
  2823. How do I utilize that
  2824. Can I catch them and harness this power????????
  2825. no but someone is working on it
  2826. someone with more money and power than us
  2827. Can I catch them and harness this power????????

    PubMed
    Citrate is an essential substrate for energy metabolism that plays critical roles in regulating cell growth and survival. However, the action of citrate in regulating metabolism, cognition, and aging at the organismal level remains poorly understood. Here, we report that dietary supplementation with …
    Image
  2828. yooooo
  2829. 😄
  2830. you know where this goes
  2831. if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
  2832. 🍋
  2833. motherfucker
  2834. if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
  2835. if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
  2836. https://www.frontiersin.org/articles/10.3389/fnins.2020.00612/full This ALA I’ve been taking is an iron chelator :Holyshig:
    Disruption of neuronal iron homeostasis and oxidative stress are related to the pathogenesis of Parkinson’s disease (PD). Alpha-lipoic acid (ALA), a naturally occurring enzyme cofactor with antioxidant and iron chelator properties, has many known effects. It is known that ALA has neuroprotective effects on PD, but its underlying mechanism remain...
    Image
  2837. not sure I need DFO then?????
  2838. not sure I need DFO then?????

    no one needs DFO
  2839. people need to get their shit straight
  2840. https://open.spotify.com/track/04zxGiXcmNQ0m9oDXtwo18?si=ZRaU6GGgT7SNYe8gwrcYXg This song by gorillas has the same back track as a sewerslvt song
  2841. But without the breaks rip
  2842. gorillaz
  2843. my fav band
  2844. ...
  2845. when I was 12 yrs old
  2846. when I was 12 yrs old

    Lmaooo same
  2847. Ive gone down the music rabbit hole a bit lately and realized I need to find some more accessible music for playing around family lol
  2848. I left a cut cucumber on my desk for 24 hours
  2849. I bet it's toxic now
  2850. Ive gone down the music rabbit hole a bit lately and realized I need to find some more accessible music for playing around family lol

    that's one of the reasons not to have a family
  2851. familyyyyyyyyyyyyyyyyyy
  2852. but they take care of meeeeee
  2853. :emoji_52:
  2854. but they take care of meeeeee

    21 is the perfect time to change that
  2855. lemons will liberate us folks
  2856. if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
  2857. will use citrate as filler now for everything
  2858. it's fucking ridiculous
  2859. Que
  2860. Que

    do you even citratize yourself
  2861. Nah scurvy-maxxing
  2862. Nah scurvy-maxxing

    missing out
  2863. I'm gonna start dosing it constantly
  2864. hmmm
  2865. maybe citrate tablets in shape of lemon
  2866. Effects?
  2867. yeheheheheee
  2868. 🍋
  2869. 🍋
  2870. if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
  2871. Limunska kiselina, na usta ide mi slina, ja volim taj spoj, ja sam mašina, ja sam stroj.
  2872. it's ridiculous
  2873. :emoji_25:
  2874. :emoji_25:

    kek
  2875. there must be some errors with that metric
  2876. it's impossible to maintain the ratio they suggest
  2877. Going gorilla on the leafy greens is the only way without supplements
  2878. Going gorilla on the leafy greens is the only way without supplements

    I see no point
  2879. people eat vegan food, lift weights and have the same bone density
  2880. my bones are good I repeatedly put them to various tests
  2881. average phosphorus intake is 2g, often more
  2882. average calcium intake 600 mg
  2883. What are some good bone tests
  2884. What are some good bone tests

    falling off a bike
  2885. hitting shit
  2886. skateboarding
  2887. eventually you get a free x ray
  2888. for your feats of bravery
  2889. will use citrate as filler now for everything

    I bought a lb of citric acid, but have not been able to find it for weeks
  2890. I bought a lb of citric acid, but have not been able to find it for weeks

    it's cheap as f
  2891. buy another one
  2892. and another one
  2893. and another one
  2894. it's cheap as f

    I need to buy a bunch of sorghum anywho
  2895. tried 6 mg Agomelatine subL
  2896. stings like a mofo
  2897. not doing this again
  2898. time to start lycopening the shit out of my diet
  2899. joined the party.
  2900. Gonna get some lemon juice
  2901. Careful, Lycopene is a 5AR inhibitor, can be fatiguing to those with lower levels of DHT I take about 15mg supplemental most days
  2902. Scientists are experimenting with larva fat to replace butter. They soak insects in water and then mush them with a blender before centrifuges separate a butter-like substance, which the team then uses to bake with https://t.co/dIkTtYWV68
    Likes
    2397
    Retweets
    1048
    Twitter02/29/2020
  2903. exercise-induced BDNF gets rid of this chloride accumulation

    Do you have any studies on that? Know why that might be? Maybe it’s partly reliant on mechanical filtration the way the lymphatic system is??? Or else is there probably another pathway out there we could theoretically hack??
  2904. Does anyone know a good source for pregnenolone nasal sprays?
  2905. hopped into the server.
  2906. Careful, Lycopene is a 5AR inhibitor, can be fatiguing to those with lower levels of DHT I take about 15mg supplemental most days

    Nah that's not a prob. Eat your tomato and have it too
  2907. welcome to madman's land
  2908. pinned a message to this channel. See all pinned messages.
  2909. pinned a message to this channel. See all pinned messages.
  2910. Do you have any studies on that? Know why that might be? Maybe it’s partly reliant on mechanical filtration the way the lymphatic system is??? Or else is there probably another pathway out there we could theoretically hack??

    Nah transporters become regulated. Exercise is mainly an epigenetic intervention. This is why we don't have drugs that mimic exercise fully. It's effects are too complex but also we only have a few thorough screenings for epigenetic effects of small molecules.
  2911. pinned a message to this channel. See all pinned messages.
  2912. pinned a message to this channel. See all pinned messages.
  2913. pinned a message to this channel. See all pinned messages.
  2914. pinned a message to this channel. See all pinned messages.
  2915. pinned a message to this channel. See all pinned messages.
  2916. pinned a message to this channel. See all pinned messages.
  2917. pinned a message to this channel. See all pinned messages.
  2918. If you want to die read pinned messages 😂
  2919. Such a good albummmm
  2920. Did you see his new single? Also very good.
  2921. Did you see his new single? Also very good.

    surprisingly banger thanks for lmk
  2922. man is evolving
  2923. master of rhythm, holder of meaning, wielder of style
  2924. joined the party.
  2925. I'm excited for his new album
  2926. Was bumping DiCaprio 2 like crazy when it came out
  2927. surprisingly banger thanks for lmk

    Yep, he is indeed evolving One of the goats in the future probably.
  2928. Yep, he is indeed evolving One of the goats in the future probably.

    Really
  2929. JID is very talented but I don't think I can out him up there yet until he proves that with a project
  2930. Artists like Baby Keem is probably one of the next best/big artists
  2931. Does anyone know a good source for pregnenolone nasal sprays?

    Major ven here don't have it
  2932. Took 7g shrooms once and basically felt sober
  2933. Took 7g shrooms once and basically felt sober

    bunk mushrooms? Cubes?
  2934. 🧊 s
  2935. A friend and I took the same stuff before and it was good
  2936. Same batch
  2937. hmm
  2938. r u on ssris
  2939. or alike
  2940. No
  2941. BOT

    GG , you just advanced to level 4!
  2942. THC gives me more visuals than the few times I took shrooms
  2943. LSD is another story
  2944. THC does produce visuals for me
  2945. mushrooms produce visuals as well but they're nothing compared to the whole experience I described in the article
  2946. I have met a few people like u
  2947. with variable response to the same mushrooms
  2948. I find it peculiar
  2949. even DMT some people are immune at times
  2950. I haven't a clue why this is
  2951. maybe there's an endogenous antagonist of 5ht2a
  2952. Low 5ht2a-mglur2 heteromerization?
  2953. Low 5ht2a-mglur2 heteromerization?

    the irregular pattern of this phenomenon would suggest otherwise
  2954. I mean I wasn't "sober" that one time but it was just like the mind was too clean
  2955. it appears more likely there's a protein or even a small molecule that prevents the effect of 5ht2a activation on mGlur2
  2956. we're all gonna make it bruhs
  2957. decided I'll go persuade my doctor to prescribe me cetirizine tomorrow wish luck
  2958. Overdose! Overdose!
  2959. Never OTC did not work for me with it
  2960. Never OTC did not work for me with it

    high dose nettle extract did make me regrow my hair in 2015 but it also produced gynecomastia and fluid discharge in the right boob
  2961. Yeah possibility is these things is considerable but if you found something's works then its easy to mitigate the side effect in way or other
  2962. Yeah possibility is these things is considerable but if you found something's works then its easy to mitigate the side effect in way or other

    yeah I could go have gyno surgery
  2963. but that's too expensive for my cheap booty
  2964. Nahh not that lol
  2965. there anti gyno meds
  2966. also it produced erectile dysfunction
  2967. tho' reversible
  2968. How does nettle do it from first
  2969. How does nettle do it from first

    it is likely multimodal
  2970. I have produced my own extract, nothing else worked
  2971. tea, topical, etc. Only my own extract
  2972. oral
  2973. We have a lot of bisexuals here I would told them to grow boobs :emoji_51~1: :emoji_49~1:
  2974. idk about that
  2975. gynecomastia is very unpleasant I would recommend it to nobody
  2976. it itches, reacts to random stuff like foods, temperature change, touch, etc.
  2977. it produces a discharge which would be embarassing for anyone
  2978. but that's just my experience
  2979. How does nettle do it from first
  2980. this hair growth effect and the accompanying feminization and erectile dysfunction is likely due to the inhibition of 5 alpha reductase.
  2981. BOT

    GG , you just advanced to level 14!
  2982. the hair growth is also likely to be promoted by it's antiinflammatory properties.
  2983. it is also an aromatase inhibitor which would make one think it would stop gynecomastia, but the net effect is negative because DHT is a powerful inhibitory factor in the breast tissue and even without estrogen, with enough prolactin and IGF1 the tissue can grow.
  2984. all in all it's a very dirty drug if we're looking at it from this perspective. the negative effects can even be pronounced with topical use.
  2985. interesting
  2986. BOT

    GG , you just advanced to level 13!
  2987. brehhhh homie got fucked up
  2988. What heppen
  2989. What heppen

    I was referring to the guy getting gyno and ED from nettle extract
  2990. I did fall off my skateboard recently and my back hurts rn tho :/
  2991. I was referring to the guy getting gyno and ED from nettle extract

    Don't worry I reversed it both
  2992. Prove it post ur chest area
  2993. I am becoming Goku
  2994. someone help me source galantamine bulk pleaaase
  2995. I need 100 g
  2996. pure powder obviously
  2997. roflmaooo
  2998. PubMed
    A lower incidence of dementia in bipolar patients treated with lithium has been described. This metal inhibits the phosphorylation of glycogen-synthase-kinase 3-α and β, which are related to amyloid precursor protein processing and tau hyperphosphorylation in pathological conditions, respectively. F …
    Image
  2999. 300 mcg
  3000. cool
  3001. transcend motherfuckers
  3002. there anti gyno meds

    Anti-prolactin compounds?
  3003. Anti-prolactin compounds?

    Modafinil fixed it
  3004. also fasting, Rapamycin
  3005. Modafinil fixed it

    Interesting.
  3006. lots of endurance exercise
  3007. AMPK activation
  3008. nook IGF1 mTOR
  3009. activate dopamine receptors
  3010. downregulate 5HT2C
  3011. etc
  3012. Interesting.

    Armoda downregulates prolactin and nightly GH release
  3013. dual action very effective
  3014. I have to use agomelatine to maintain quality of sleep
  3015. but this helps the gyno even more
  3016. however I wasn't doing this all because of gyno but because of the nootropic effect
  3017. getting rid of the gyno was a nice side 😛
  3018. I'm making a breakcore mix motherfucker
  3019. Armoda downregulates prolactin and nightly GH release
    PubMed
    The noradrenergic locus coeruleus is a major wakefulness-promoting nucleus of the brain, which is also involved in the regulation of autonomic and endocrine functions. The activity of the locus coeruleus is believed to be tonically enhanced by a mesocoerulear dopaminergic pathway arising from the ve …
    Image
  3020. I'm making a breakcore mix motherfucker

    Link it when it's done.
  3021. Link it when it's done.

    in a few mo roflmao
  3022. in a few mo roflmao

    Exactly. I will remember.
  3023. I'm cheap I don't wanna buy a turntable so I just wait for my friend to let me play at his house 😛
  3024. I'm cheap I don't wanna buy a turntable so I just wait for my friend to let me play at his house 😛

    Maybe try it first at your friend's house.
  3025. Or borrow it for an undefined amount of time if he's not using it.
  3026. turntable is the last on my list lel
  3027. nah he's using it
  3028. that's why I must wait
  3029. already played a few times
  3030. it's fun as hell
  3031. Playing at a party as a DJ is on my bucket list.
  3032. it's so cool
  3033. when you see drugged out people drooling over the speakers
  3034. when you see drugged out people drooling over the speakers

    Utopia.
  3035. Utopia.

    and you're all clear headed nooted up ready to strike the mofo who breaks the equipment :emoji_50~1:
  3036. then you shut off bass and echo and reverb over only the high
  3037. motherfuckers transcend
  3038. sadly they don't remember it day after
  3039. Armoda downregulates prolactin and nightly GH release

    Oh dayum are there actual differences like this between moda and armoda beyond half life or is that just what you were taking
  3040. Oh dayum are there actual differences like this between moda and armoda beyond half life or is that just what you were taking

    armoda is the active part of modafinil
  3041. I'm not sure esmoda does anything worthwhile
  3042. So is S-moda no?
  3043. I thought S-moda is just modafinl with like 6 hour half life. But no clinical efficacy or something
  3044. I forgot to tell you I don't hate all peptides. I love dipeptides. They're all orally active, never heard of antibodies to them, they are usually very stable compounds, they're easy and cheap to produce.
  3045. they can also be grafted to various small molecules to yield extra activities, reduce sides, improve potency, pharmacokinetics, etc.
  3046. I forgot to tell you I don't hate all peptides. I love dipeptides. They're all orally active, never heard of antibodies to them, they are usually very stable compounds, they're easy and cheap to produce.

    not all peptides are created equal
  3047. Image
  3048. not all peptides are created equal

    indeed, but the rule of thumb goes, the bigger the worse
  3049. I'm making a breakcore mix motherfucker

    :Waow:
  3050. I wish you good luck, break core soothes the soul!!!!!!!!!!!
  3051. u got me hooked
  3052. riding with breakcore is unlike anything else
  3053. I have not even taken armoda with it yet
  3054. u got me hooked

    I got into breakcore by listening to sewerslvt in 2020 cause the people I hung out with in vr played it a lot
  3055. This is a really nice playlist
  3056. and you're all clear headed nooted up ready to strike the mofo who breaks the equipment :emoji_50~1:

    Lol something along those lines.
  3057. u know what really fascinates me
  3058. the fact that serotonin metabolism is dependent on dopamine metabolism
  3059. it is so so perfect
  3060. God is great
  3061. we need to find ways to make DBH go brr
  3062. cuz once we do we will improve our circadian rhythms immeasurably with no detriment
  3063. it will reduce oxidative load immensely as well
  3064. increase brain plasticity
  3065. etc.
  3066. just time selective overexpression of a single enzyme
  3067. https://pubmed.ncbi.nlm.nih.gov/12650926 Sphingosine 1 phosphate is a sphingomyelinase inhibitor / FIASMA
    PubMed
    Sphingosine-1-phosphate (Sph-1-P) regulates critical cellular functions including cell proliferation, differentiation, angiogenesis, and cell survival. However, its mechanisms of action are incompletely understood. Here, we show a novel biological effect of Sph-1-P: inhibition of acidic sphingomyeli …
    Image
  3068. pray for haiti is such a good album man
  3069. Everyone welcome !
  3070. Everyone welcome The Duke of Wellington!

    Sticker, Wave
  3071. the adder is getting fatter
  3072. The Olmec tribes created images of a toad god of rebirth, eating its own skin. It is reborn by consuming itself, caught in a cycle of death and rebirth, like people, and like the natural world itself. 😮
  3073. Image
  3074. I haven't a clue why but lately I started to like the music of these two sleezebags
  3075. Lmfao
  3076. Image
  3077. Kodak isn't that bad
  3078. French Montana though
  3079. him sleezing all over the beat
  3080. I like it
  3081. is it gay
  3082. No
  3083. French Montana though

    umma change yuh mind
  3084. check his delivery here
  3085. so fucking hype
  3086. riding 60 flat on my bike listening to it
  3087. tbh
  3088. not much else
  3089. roflmao
  3090. Busta tho
  3091. lights the network every single time
  3092. check his delivery here

    I like repping my fellow Moroccans but I'm not really a fan of his music
  3093. Fivio Foreign is great though
  3094. Don't have an idea about french rap
  3095. Listen to westside Gunn pray for Paris album though
  3096. That & pray for Haiti is what I've been listening a lot to lately
  3097. Original message was deleted.

    what strains
  3098. anything else?
  3099. good luck
  3100. outdoors?
  3101. it's a bit late for that
  3102. I'm an agriculturalist btw
  3103. I can help u if u have questions
  3104. I just realized cetirizine is one-time-prescription in my country
  3105. fuck that
  3106. I need a new doc
  3107. someone I can call and say hey man gimme this gimme that
  3108. BOT

    GG , you just advanced to level 1!
  3109. Original message was deleted.

    everything is so strict here
  3110. you can't get almost nothing without prescription
  3111. and the one-time-prescriptions are a great nuisance
  3112. Croatia
  3113. Original message was deleted.

    they're all digital here you can't cheat it
  3114. unless you hack and that's terrorism
  3115. Lol I got cit for 100mg/0.5$ unlimited amount
  3116. This fucked up country has some benfits
  3117. This fucked up country has some benfits

    they usually do
  3118. Lol I got cit for 100mg/0.5$ unlimited amount

    do you know if there's systemic absorption with topical
  3119. do you know if there's systemic absorption with topical

    There is no study made for this subject
  3120. There is no study made for this subject

    urine HPLC would be enough to prove this
  3121. why
  3122. Original message was deleted.

    IMO it would produce an inoptimal state
  3123. no it would be like Buspirone
  3124. it would feel good yes
  3125. but it would decrease cognition and analytical thought, increase risk of dementia
  3126. it would create a passive coping state
  3127. we went over this a few days ago
  3128. it's a very dumb way to stop depression
  3129. BOT

    GG , you just advanced to level 15!
  3130. 🤦‍♂️
  3131. anyways if I could I would knock out post synaptic 5HT1A
  3132. Original message was deleted.

    because it generates a warrior-like mindset
  3133. BOT

    GG , you just advanced to level 2!
  3134. depends
  3135. if you wanna be a pussy yes
  3136. 😂
  3137. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses

  3138. Original message was deleted.

    I prefer to improve my life before I improve my mind
  3139. for that I need low 5HT1A
  3140. and high 5HT2A
  3141. they form heteromers so you can't have both
  3142. Original message was deleted.

    I like to call it sincere escapism
  3143. make effort to make your life self sustainable
  3144. freedom from other people decreases stress levels globally
  3145. Message could not be loaded.

    no it's not
  3146. it never is
  3147. it's a spectrum
  3148. but ultimately there is always someone you need for something
  3149. you grow you food?
  3150. your produce your own energy?
  3151. your own medicine?
  3152. drugs?
  3153. you can spend 5 yrs alone without yearning for social connection?
  3154. you can spend 5 yrs celibate without relapsing masturbating?
  3155. etc.
  3156. so many levels of freedom in life
  3157. at the end of it all
  3158. you live in a country
  3159. that country has laws
  3160. which limit your freedom immensely
  3161. Message could not be loaded.

    I disagree
  3162. this is 5HT1A thinking
  3163. we need to produce solutions, if we don't, everything will crumble
  3164. 2nd law of thermodynamics
  3165. whatever doesn't improve worsens
  3166. I would rather stay in this biological form eating delicious food for 10k yrs
  3167. Image
  3168. Message could not be loaded.

    no that is in the case of reversed monoamine transporters
  3169. this state is anti-immortalist
  3170. creates immense oxidative load
  3171. I work against this state
  3172. Original message was deleted.

    no
  3173. you inhibit MAO B in this state and WORSEN the oxidative stress
  3174. PubMed
    It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonist …
    Image
  3175. Home BLOW YOUR MIND WITH SCIENCE
  3176. Original message was deleted.

    autoxidation
  3177. MAO B is endogenous
  3178. why would the body produce a protein that makes damage to the body
  3179. it makes no sense
  3180. MAO B is protective against VMAT2 dysfunction
  3181. you don't have understanding of this sry I'm not here to argue
  3182. Original message was deleted.

    study release dynamics
  3183. you will understand that vesicular release is 100% necessary to keep oxidative load restrained
  3184. Original message was deleted.

    actually I prefer to call those substances reuptake transporter agonists
  3185. they don't inhibit the transporter, they reverse it
  3186. like cocaine, methylphenidate, amphetamine
  3187. modafinil is a true reuptake inhibitor
  3188. Original message was deleted.

    again, your understanding is brief
  3189. you don't have a clue about transporter conformations
  3190. I can teach but you seem stubborn, set in your ways
  3191. BOT

    GG , you just advanced to level 3!
  3192. mkay
  3193. so the transporters can have 3 states
  3194. one is uptake, that's normal, it pulls monoamines to the neuron cytosol from the presynaptic cleft and from cytosol to vesicules
  3195. another is inhibition, it's when the transporter does not work anymore
  3196. and the third state is called open-to-out conformation, it's when the transporter leaks contents in the opposite direction of normal
  3197. the third state is what methylphenidate, cocaine and amphetamine produce
  3198. mph and cocaine do not touch VMAT2
  3199. but amphetamine produces open-to-out conformation for VMAT2 too
  3200. this creates a brain state that's independent of cellular energy, it does not matter if mitochondria produce ATP or not, if you eat enough, if you're healthy or sick
  3201. Croatia

    why not thailand
  3202. Why are all the other guys' messages deleted tho
  3203. Farewell chlo
  3204. just showed up!
  3205. Good to see you, .
  3206. you don't have a clue about transporter conformations

    So citric acid is based?
  3207. Fuck Thailand ahhh Why you deleted the message 😅
  3208. Dw about it
  3209. What type of stf
  3210. BOT

    , you just advanced to level 2 respect++
  3211. Std
  3212. Cab I get citric acid from lemon juice?
  3213. Nooo
  3214. Cab I get citric acid from lemon juice?

    they use it to convert some drugs, so yes
  3215. Addictio cause you to be smart
  3216. Idk how much
  3217. I'll just wing it
  3218. Taking creatine and lemon juice
  3219. Cab I get citric acid from lemon juice?

    if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
  3220. Lmao
  3221. Plasticity receptors seems to have other functions then this , which I don't know shit about
  3222. Anyone know more feel free to give input
  3223. So citric acid is based?

    Manufactured citric acid no wtf. Who gave u that idea?
  3224. Resolution thought
  3225. I prefer to improve my life before I improve my mind

    🥴
  3226. Manufactured citric acid no wtf. Who gave u that idea?

    VP
  3227. Resolution thought

    ?
  3228. VP

    Who is VP
  3229. Who is VP

  3230. Oh
  3231. Just to clarify MCA should be avoided. Citric acid derived from food is fine (there is no supplement for this)
  3232. ?

    Neuron spike model of working memory
  3233. Just to clarify MCA should be avoided. Citric acid derived from food is fine (there is no supplement for this)

    What's the rationale for avoiding manufactured citric acid?
  3234. It's not just number of items. It's one item and the resolution that that item is represented at
  3235. Yeah what exactly makes mca bad but citric acid ok
  3236. Yeah what exactly makes mca bad but citric acid ok

    Sometimes synthesized versions of molecules have no beneficial, or even paradoxical effects compared to natural source. Astaxanthin is an example of this
  3237. Like a TV is a device which is 1st order of abstraction. Then the TV is the TV. Then specific details like the show playing, the model, the color. Then hyper specific details like the button placement and the writing. This is how working memory works. It's not just a few items
  3238. What's the rationale for avoiding manufactured citric acid?

    Approximately 99% of the world production of MCA is through microbial processes using toxic black mold Aspergillus niger [1].
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097542/
    PubMed Central (PMC)
    Citric acid naturally exists in fruits and vegetables. However, it is not the naturally occurring citric acid, but the manufactured citric acid (MCA) that is used extensively as a food and beverage additive. Approximately 99% of the world’s production ...
    Image
  3239. Each level down you have exponentially more things to remember since its higher resolution
  3240. Sometimes synthesized versions of molecules have no beneficial, or even paradoxical effects compared to natural source. Astaxanthin is an example of this

    I dont think thats the case with citric acid
  3241. High IQ individuals might seem to have low WM sometimes but that's just with one resolution
  3242. MCA comes from black mold. It’s too expensive for companies to derive it naturally from food
  3243. Lmfaoooo what
  3244. Nigga thinks they are making citric acid out if black mold
  3245. Nigga thinks they are making citric acid out if black mold

    PubMed Central (PMC)
    Citric acid naturally exists in fruits and vegetables. However, it is not the naturally occurring citric acid, but the manufactured citric acid (MCA) that is used extensively as a food and beverage additive. Approximately 99% of the world’s production ...
    Image
  3246. Apergillus niger and candida is not black mold
    Image
  3247. Lmfao
  3248. Those are native bacteria in your stomach
  3249. This guy doesn’t know that aspergillus niger IS black mold
  3250. This is four case reports, and the only postulated mechanism is black mold pathogens, which I assume is able to be purified out. Also, IIRC, Aspergilus Niger isn't the "black mold" that tends to cause severe respiratory/CFS diseases, but it's cousin, aspergailus Fumigatus. I'm sure that aspergilus could cause issues in people who have an allergy, But IIRC it's mostly a threat in its live form, when it tries to colonize the lungs
  3251. Yeah im retarded..I got it mixed up with the aspergillus you ferment miso with
  3252. This guy doesn’t know that aspergillus niger IS black mold

    It's one of the big three, but IIRC by far the least toxic, mostly a threat due to infection of airways
  3253. Still the theory is what, that toxins are somehow staying in the citric acid?
  3254. It's the one that frequently grows on fruits and in onions
  3255. Still the theory is what, that toxins are somehow staying in the citric acid?

    I suspect it is an allergic response from people that are allergic to the mold
  3256. I have CFS from living in a house that wound up being condemned due to Starchybortris contamination, had pneumonia off and on for a year
  3257. So I could possibly be in that camp, but since it's a different strain of fungi, I doubt it
  3258. I suspect it is an allergic response from people that are allergic to the mold

    Isnt that the same thing, you are saying something in the mold is staying in the citric acid even after purification
  3259. Isnt that the same thing, you are saying something in the mold is staying in the citric acid even after purification

    That was my takeaway from reading the article, also the only plausible mechanism I can think of
  3260. But I'm sure you can get as much or more Aspergillis, in whole form, just from eating produce
  3261. Including fresh lemons 🍋
  3262. Yeah thats interesting
  3263. Its always worrying when the fact checkers tell you not to worry about something
    Image
  3264. Yeah im retarded..I got it mixed up with the aspergillus you ferment miso with

    🤓
  3265. Fuck you blank
  3266. BOT

    , you just advanced to level 3 respect++
  3267. It's the one that frequently grows on fruits and in onions

    like in my medjool dates?
  3268. like in my medjool dates?

    Indeed
  3269. The dreaded "black pit"
  3270. EXTERMINATE!!!!
  3271. Extracting dxm looks weird
    Image
    Image
    Image
    Image
    Image
    Image
  3272. Fuck you blank

    hi
  3273. So citric acid is based?

    Y
  3274. Extracting dxm looks weird

    Prutty
  3275. Cab I get citric acid from lemon juice?

    I recommend tomatoes but lemon is good as well
  3276. > Approximately 99% of the world production of MCA is through microbial processes using toxic black mold Aspergillus niger [1]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097542/

    It's a pure substance who cares where it comes from roflmao. You won't get mold poisoning with citric acid. However they may be other treaths using high doses. I am investigating
  3277. It is an approved food additive so you can use small doses with no worry
  3278. like in my medjool dates?

    The faint white coating you can observe on the skin of sweet fruits is a strain of yeast similar to Baker's and Brewer's yeast, S. cerevisiae
  3279. Harmless 👻
  3280. Every other color on food means it has gone bad potentially deadly. If it's thick white it can still be mold but hasn't sporulated yet. Throw
  3281. Its always worrying when the fact checkers tell you not to worry about something

    Looool
  3282. When an agonist bind to receptor complex its agonist its receptor, but prevent the other receptor from getting agonisted without providing any agonist efficacy in replacement
  3283. It's a pure substance who cares where it comes from roflmao. You won't get mold poisoning with citric acid. However they may be other treaths using high doses. I am investigating

    Uncompensated metabolic acidosis?
  3284. The faint white coating you can observe on the skin of sweet fruits is a strain of yeast similar to Baker's and Brewer's yeast, S. cerevisiae

    Aspergillis often grows on the inside of dates, between the fruit and the pit. Nicknamed the black pit, absolutely gross, but I'm sure there's plenty in small amounts on lots of dates, that I don't notice. This is the same kind that grows between the paper/layers of onions. It doesn't produce substantial amounts of aflatoxin, like its cousin aspergillis fumigatus, I don't consider it to be a huge health hazard by any stretch when consumed in tiny quantities in food for most people.
  3285. I'm earing Muscadine grapes from a friend's orchard right now. I'm sure some of these have aspergilis growing in/on them.
  3286. I think peanuts often get contaminated with aflatoxin, though, possibly through fumigatus, or another strain
  3287. BTW Muscadine grapes? One of the healthiest things in existence, buddy. Its like the American AMLA berry
  3288. What is the primary endogenous super agonist I wonder?
  3289. What is the primary endogenous super agonist I wonder?

    Bofutenine
  3290. 🐸
  3291. 5 Meo as well
  3292. Serotonin itself could probably be psychedelic in specific brain states
  3293. DMT possibly???
  3294. DMT possibly???

    Prolly but it is weaker compared to what I mentioned
  3295. Serotonin itself could probably be psychedelic in specific brain states

    It’s no superagonist tho!
    Image
  3296. It’s no superagonist tho!

    The comformation of the heteromer can change
  3297. Owhhh so many factors
  3298. What’s are the most common natural situations in which 5HT2a and mGluR2 interact, what is the natural function of their relationship????
  3299. Can only wonder
  3300. The comformation of the heteromer can change

    Altered topography 😵‍💫
  3301. What is the primary endogenous super agonist I wonder?

    DMT but trigger just when you die
  3302. DMT possibly???

    Yeah
  3303. DMT but trigger just when you die

    Nah I'm pretty sure schizoautist spectrum people release it on the daily
  3304. We need someone on benzo here
  3305. why did you steal Swiss chads PFP this is so confusing
  3306. Image
  3307. Make her look to the right so we can tell you apart
  3308. Horizontal flip
  3309. It is an approved food additive so you can use small doses with no worry

    Lmfao the term approved means nothing
  3310. Keep clinging to your FDA approved nonsense. You will definitely outlive us all
  3311. It's a pure substance who cares where it comes from roflmao. You won't get mold poisoning with citric acid. However they may be other treaths using high doses. I am investigating

    Blocked for spreading your false information and endangering people
  3312. BOT

    , you just advanced to level 3 respect++
  3313. Majority always label minority opinion as pseudoscience
  3314. Majority always label minority opinion as pseudoscience

    The prob is he tried to substantiate his statement saying citrate is not healthy because it's produced by Aspergillus sp. This is nonsense. Now he's saying I'm endangering ppl saying they can consume something everyone consumes anyways. Obv if u were to capsulate pure citric acid it would cause irritation but dude use common sense and do look it up. It's safe to add to water at least 5 g/L if not more
  3315. It was just thought
  3316. Majority always label minority opinion as pseudoscience

    This is true.
  3317. Image
    Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolysed by specific glycosidases, some also catalyzing synthetic transglycosylation reactions. The documented value of plant-derived glycoconjugates to beneficially modulate metabolism is first addressed. Next, focus is given to glycosidases, the...
    Image
  3318. why does alcohol cure my depression
  3319. why does alcohol cure my depression

    Alcohol being a weak Gaba A agonist probably helps. 👍
  3320. why does alcohol cure my depression

    Seems Your depression is anxiety based
  3321. Seems Your depression is anxiety based

    most likely so id say
  3322. most likely so id say

    There alcohol acculvent you might cycle them
  3323. Prazepam( slowest benzo in tolerance)
  3324. Pregabaline (calsium channel antagonist)
  3325. Etifoxin (gaba a-rho agonis)
  3326. Pregabaline (calsium channel antagonist)

    pregabaline really messes up with my memory though I tried it makes me rather foggy
  3327. The only anti anxiety that don't mess with memory (they even increase it) is SNRIs exactly strongest one, venalafaxine
  3328. Did you took any before
  3329. Did you took any before

    no, but I took NSI 189 before (for 3-4 months) and I feel my anxiety went up significantly after that, as well as my fear response
  3330. BOT

    , you just advanced to level 1 respect++
  3331. Mislead, SNRIs us serotonin adrenaline's reuptake inhibitor
  3332. This the exact feeling
  3333. Image
  3334. Face looking is 100%
  3335. ?
  3336. Lool you will stay a boy
  3337. I mean the confident etc
  3338. Alcohol being a weak Gaba A agonist probably helps. 👍

    Time to switch to pregnenolone 👍
  3339. Click to see attachment

    Give me
  3340. Face looking is 100%

    She Korean you figure or what?
  3341. They’re expert biohackers over there lol
  3342. gigantic boobs between
  3343. - complains of back pain all the time - have to be stabilized while pounding What is the benefit? 🙀
  3344. feminine feeling ᴗ
    Image
  3345. Beauty
  3346. Beauty is a side effect of function
  3347. Y'all confused as hell
  3348. Function of boob is breastfeeding. if you don't plan to do that it's a burden and looks ugly
  3349. Image
  3350. Give me

    No
  3351. I was think its easy to run server without ban
  3352. but when you start being an admin you will find there a lot of variables you was not know about, define why admins have to ban
  3353. discord admins must be ugly perverts who never leave their room, you are not fit for that job!
  3354. - complains of back pain all the time - have to be stabilized while pounding What is the benefit? 🙀

    training back muscles would be a good idea - however how to do that without getting a wide back?
  3355. Function of boob is breastfeeding. if you don't plan to do that it's a burden and looks ugly

    my personal assumption is that female human breast tissue above an B cub is like a peacock tail. And i want to know what happend in prehistoric times to give such a huge selection preasure for that?
  3356. Lets someone narcissistic attack you here and I'll get popcorn
  3357. instead of banning him
  3358. I have more tolerance then others
  3359. nah narcissm is one of the dark traits i did not get
  3360. But temp ban mostly will be routine
  3361. reminds me, in the quail to limusaurus biohacking server was a guy who "did not believe in dinosaures" because they are to big. We all where sad when he left the seerver. It was fun!
  3362. Better then you gain alot of friends and you found your self parama banned
  3363. nah, friends are just an illusion. That way we don't have to admit to ourself that we use humans just for their benefits, while we help them to gain other benefits as well
  3364. Function of boob is breastfeeding. if you don't plan to do that it's a burden and looks ugly

    Function of boob is mostly fertility signalling tbh
  3365. also somewhat cultural
  3366. romans didnt like big boobs because they thought they were comical
  3367. i LOVE big boobs
  3368. Anyone here try j147
  3369. romans didnt like big boobs because they thought they were comical

    Yeah right
  3370. Yeah right
    Ancient Roman apodesme, worn by both women and men, folded from a single piece of fabric. The breast band was a normal, if optional, item in a woman’s underwear. Women in Ancient Rome adopted a form...
    Sartorial Adventure
  3371. Yeah thats fake
  3372. cope
  3373. roman sculptures in contrast with other civilizations, depicted ideal female forms with small comparatively small breasts
  3374. rome
    Image
  3375. india arround the same period
    Image
  3376. romans didnt like big boobs because they thought they were comical

    or big dicks that's why all of their male statues have small penises. Their theory was that the longer the penis the more savage/animalistic the person. A small penis was a sign of an intellectual. :emoji_49:
  3377. Image
  3378. Image
  3379. Image
  3380. or big dicks that's why all of their male statues have small penises. Their theory was that the longer the penis the more savage/animalistic the person. A small penis was a sign of an intellectual. :emoji_49:

    I didn't want to contribute to the stereotype that otters are aggresive, savage predators... but alas.
  3381. Those don't have :emoji_24:
  3382. or big dicks that's why all of their male statues have small penises. Their theory was that the longer the penis the more savage/animalistic the person. A small penis was a sign of an intellectual. :emoji_49:

    Or they actually just had small dicks and they knew that making that excuse would make future historians think that they were just lowballing their cocks
  3383. BOT

    , you have advanced to lvl 6 respect++ :emoji_51:
  3384. What yall think about nardil
  3385. Its maio a/b selective irrivisible inhibitor
  3386. can be ultimate biohacking tool
  3387. Instead of spending few k in increasing aadc activity by providing it co-factor , which will end with major oxidative problems due to increased catabolism
  3388. You can just inhibit monoamine catabolism
  3389. from then you will need 90% less bromantan then normal people
  3390. from then you will need 90% less bromantan then normal people

    how do I shrink my amygdala
  3391. how do I shrink my amygdala

    Nardil inhibit other enzyme that breakdown gaba and in therapy doses
  3392. Making it superior then other for social anxiety
  3393. For maio You have inhibited the primary moa for the body to breakdown
  3394. Due to irrrevisible inhibition The body need 14 days to refill maio stockage, and you need just one nardil attached to the enzme to unactivate it forever
  3395. are there any bad side-effects
  3396. The only thing that made maio inhibitors deprecated is that you can't eat cheese or any high thyramin food with it
  3397. Because thyramin is adrenaline releasing agent
  3398. Cause hypertension crisis
  3399. The effectiveness of maios was not able to make them stay in use, and replaced by lower efficiency less side effect alternative SSRIs
  3400. BOT

    , you have advanced to lvl 14 respect++ :emoji_51:
  3401. To solve hypertension crisis when your adrenaline baseline is 1 there thershould ~3 if you increased aderanaline more then it, then you get hypertension problems
  3402. The problem that maios increase it 5 times
  3403. What you need to do is antagonisting beta receptors sighlightly returning them to safe rang
  3404. our research will lead to increased crime :emoji_52~1:
  3405. our research will lead to increased crime :emoji_52~1:

    He's playing chess cop's playing checkers
  3406. discord admins must be ugly perverts who never leave their room, you are not fit for that job!

    hit him
  3407. discord admins must be ugly perverts who never leave their room, you are not fit for that job!

    :bruh:
  3408. U seem obsessed with skimpy girls bro
  3409. I thought it was a one off but now I'm sus
  3410. What's the issue
  3411. Click to see attachment

    I could have lived 70 years without seeing this
  3412. I could have lived 70 years without seeing this

    bold of you tu assume you life that long
  3413. BOT

    , you have advanced to lvl 7 respect++ :emoji_51:
  3414. I could have lived 70 years without seeing this

    Same :bruh:
  3415. Hey everyone. Soonly I will synthesize research chemical called MPEP (similar to MTEP), that have shown its efficiency in treating addiction in mices. Does anybody interested in this RC despite that fact that no one human have tried this?
  3416. Hey everyone. Soonly I will synthesize research chemical called MPEP (similar to MTEP), that have shown its efficiency in treating addiction in mices. Does anybody interested in this RC despite that fact that no one human have tried this?

    Did you tested mtep? Lithium can be alternative for all of this if it is a start for you. lithium cause learned hopelessness like mglue5 antagonist which mpep selective on it https://en.wikipedia.org/wiki/Lithium_(medication)
    Certain lithium compounds, also known as lithium salts, are used as psychiatric medication, primarily for bipolar disorder and for major depressive disorder. In these disorders, it sometimes reduces the risk of suicide. Lithium is taken orally.Common side effects include increased urination, shakiness of the hands, and increased thirst. Serious ...
    Lithium (medication)
  3417. This basically means that lithium have inhibition on that receptor which means the anti addiction effect of lethium is from there
  3418. Metabotropic glutamate receptor 5 is an excitatory Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. In humans, it is encoded by the GRM5 gene.
    Metabotropic glutamate receptor 5
    3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for ...
    MTEP
    Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain. Subsequently, it was determined that fenobam acts as a potent and selective negative allosteric modulator of the metabotropic glutamate receptor subtype mGluR5, and it ha...
    Fenobam
  3419. If modulating a feeling like hope reached its maximal benefits then you need to play with other one.
  3420. There a possibility that the effect is completely based on dose dependant curve realising the fact what "hope" is and expecting how it could cause anti addiction effect You will need high doses.
  3421. Click to see attachment

    that type of aesthetic called hime gyaru :emoji_7:
  3422. Image
  3423. that type of aesthetic called hime gyaru :emoji_7:

    I neeeed the hime gyaru haaaaat :reiflush3:
  3424. After I learned "I promise" I overused it for few weeks, just because how it sound
  3425. Now I have problem payback my promises :emoji_6:
  3426. LOL
  3427. The moment where Elon Musk made history :The successful rocket launch appeared :Then landing it to be reused elon: where the shine , this is bad :The rocket came back to work and landed smoothly
  3428. I think house flies are getting bigger
  3429. Like the one I just killed was massive
  3430. Like 3-4x the size of flies I'm used to
  3431. Ya we had a monster flying around here the other day too lol
  3432. Click to see attachment

    filter ir truly as big eyes?
  3433. filter ir truly as big eyes?

    its truly, you want one of it :emoji_52~2: ?
  3434. treat her good!
  3435. between my 2nd account her is
  3436. Nah, as big eyes are creepy in RL, my cousin and her 3 children got as big ones as well... ....besides eyes don't stay fresh for long outside the socket
  3437. Nah, as big eyes are creepy in RL, my cousin and her 3 children got as big ones as well... ....besides eyes don't stay fresh for long outside the socket

    big eyes= aniiiiiiiiiime
  3438. works only for asians
  3439. we need more collagen
  3440. Function of boob is mostly fertility signalling tbh

    Yeah in today's day and age. But it does store a lot of fat which could come in handy in prehistoric times esp during breastfeeding. I think this is the reason why it signals fertility in the first place
  3441. Pig is credible animal Give him your broken phone, trashbin, bag of expired substances and he will convert them to meat
  3442. 🍻